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Identifying microbial protease allergens through protein language model-guided homology

Authors: Kumar Thurimella, Elena Wu, Chenhao Li, Daniel B Graham, Róisín M Owens, Damian R Plichta, Caroline L Sokol, Ramnik J Xavier, Sergio Bacallado

Journal: Molecular Therapy

PubMed ID: 41722567

Doi: 10.1016/j.cels.2025.101510

Messenger RNA delivery to islet β cells using conjugated lipid nanoparticles

Authors: Jacob R Enriquez, Zhengjie Zhou, Jennifer B Nelson, Fei Huang, Kayla T Figatner, Advaita Chakraborty, Sarida Pratuangtham, Brian Xi, Sarah C May, Matthew V Tirrell, Sarah A Tersey, Yun Fang, Raghavendra G Mirmira

Journal: Molecular Therapy

PubMed ID: 41722565

Doi: 10.1016/j.xcrm.2026.102634

Products & Services: Recombinant Proteins

Identification of xenobiotics interfering with 5α-reductase (SRD5A2) activity

Authors: Jacek Kędzierski, Rianne E van Diest, Julien A Allard, Andreas M Erharter, Alex Odermatt, Martin Smieko

Journal: Molecular Therapy

PubMed ID: 41722875

Doi: 10.1016/j.toxlet.2026.111859

Products & Services: Custom Vector Construction

Targeting Langerhans cells using a modular mannosylated nucleic acid-based vaccine platform

Authors: Simon Christian Vinther, Antonia Resag, Karina Thao Thu Le, Claudia Christine Zelle-Rieser, Helen Strandt, Mette Galsgaard Malle, Stig Hill Christiansen, Barbara Del Frari, Theresia Stigger, Bastian Schilling, Jonas Wohlfarth, Steffen Thiel, Julián Valero, Patrizia Stoitzner, Jørgen Kjems

Journal: Molecular Therapy

PubMed ID: 41713595

Doi: 10.1016/j.jconrel.2026.114741

Products & Services: Custom Vector Construction

The protein phosphatase 2A-B56α complex regulates N-Myc degradation in neuroblastoma

Authors: Brian D Tran, Irene Peris, Ethan Wurman, Averie Huang, Gabrielle Hodges Onishi, Jiang Hu, Rita A Avelar, Erika A Newman, Analisa DiFeo, Caitlin M O'Connor, Goutham Narla

Journal: Molecular Therapy

PubMed ID: 41707997

Doi: 10.1016/j.jbc.2026.111298

Heterologous vs. homologous vaccine regimens: Sulfated lactosyl archaeol (SLA) archaeosome-adjuvanted SARS-CoV-2 spike protein boost following an mRNA/LNP prime induces robust and balanced immune responses

Authors: Tyler M Renner, Gerard Agbayani, Hiva Azizi, Lise Deschatelets, Renu Dudani, Blair A Harrison, Usha D Hemraz, Roger Koukiekolo, Matthew Stuible, Yves Durocher, Michael J McCluskie, Bassel Akache

Journal: Vaccine

PubMed ID: 41505874

Doi: 10.1016/j.vaccine.2025.128182

Products & Services: Codon Optimization Gene Synthesis

Humanization and engineering of protective antibodies targeting severe fever with thrombocytopenia syndrome virus Gn protein

Authors: Xuanxiu Ren, Wei Deng, Feiyang Yu, Wenhua Kuang, Heya Na, Shangyu Yang, Jiawen Sun, Jianlun Xu, Bo Shu, Sheng Cao, Xianliang Ke, Zengqin Deng, Yun-Jia Ning, Haiyan Zhao

Journal: Cell Reports

PubMed ID: 41671090

Doi: 10.1016/j.celrep.2026.116936

Products & Services: Protein and Antibody Isolation

Antifibrotic drug finerenone restores fertility in premature ovarian insufficiency

Authors: Zexiong Lin, Yuan Li, Yu Zhao, Dongteng Liu, Shuzi Deng, Jingkai Gu, Yanyan Li, Xudong Zhao, Peishan Wu, Yuan Xiao, Jiaping Su, Yiting Sun, Yihui Zhang, Yin Lau Lee, Yorino Sato, Haitao Zeng, Haonan Lu, Juanhui Zhang, Jennifer K Y Ko, Jing Zhao, Kazuhiro Kawamura, Ernest H Y Ng, Shanfang Jiang, Yu Li, Xi Xia, Karen K L Chan, William S B Yeung, Tianren R Wang, Kui Liu

Journal: Science

PubMed ID: 41643022

Doi: 10.1126/science.adz4075

Products & Services: Custom DNA/RNA Oligos

Safe and Highly Efficient Lipid-Pro-Dexamethasone Nanoparticles for mRNA Delivery and Base Editing

Authors: Yan Zong, Haiping Zhong, Yuqing Wang, Yi Lin, Linxi Zhao, Xiaoyu Wang, Jianan Cai, Haoyang Lin, Yixi Xiao, Tuo Wei, Shutao Guo, Qiang Cheng

Journal: Journal of the American Chemical Society

PubMed ID: 41733506

Doi: 10.1021/jacs.6c01708

Products & Services: Synthetic Guide RNA

GbWAKL20 Phosphorylates GbNFYB8 to Modulate Verticillium Wilt Resistance in Cotton

Authors: Guilin Wang, Qingxin Si, Zhiguo Chen, Zhe Yu, Zhan Guo, Lu Wang, Weixi Li, Wangzhen Guo

Journal: Advanced Science

PubMed ID: 41521460

Doi: 10.1002/advs.202515724

Products & Services: Catalog Antibodies