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KRASG12V/HLA-A*02:01–targeted chimeric antigen receptor T cells exhibit potent preclinical activity against solid tumors

Authors: Huimin Shao, Fei Xu, Jiangyue Xu, Lingjie Zhou, Yao Wu, Lianjun He, Xueyi Qian, Weijie He, Nanlin Jiao, Yabin Xia, Jun Zhao, Lili Sheng, Guoliang Mao, Tao Ma, Wei Wang, Shaoxiang Luo, Li Fu, Zhenyu Xu

Journal: SCIENCE ADVANCES

PubMed ID: 41719389

Doi: 10.1126/sciadv.aea2511

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Quantitative genetics of natural S. cerevisiae strains upon mating reveal heritable determinants of fitness and differential mating affinities

Authors: Sivan Kaminski Strauss, Ruthie Golomb, Donya Khoury, Noa Aharon-Hefetz, Hadar Meyer, Dayag Sheykhkarimli, Gianni Liti, Orna Dahan, Yitzhak Pilpel

Journal: Molecular Therapy

PubMed ID: 41689801

Doi: 10.1016/j.celrep.2026.116972

Products & Services: Gene Synthesis

Functional characterization of secreted Schistosoma mansoni serpin SmSPI reveals Factor XIIa inhibition as evidenced by biochemical, and human plasma assays and supported by AI-assisted structural modelling

Authors: Lukáš Konečný, Kristýna Peterková, Ingrid Hrachovinová, Alex Loukas, Tomáš Macháček, Jan Dvořák, Lucie Jedličková

Journal: Molecular Therapy

PubMed ID: 41724421

Doi: 10.1016/j.ijpara.2026.104808

Identifying microbial protease allergens through protein language model-guided homology

Authors: Kumar Thurimella, Elena Wu, Chenhao Li, Daniel B Graham, Róisín M Owens, Damian R Plichta, Caroline L Sokol, Ramnik J Xavier, Sergio Bacallado

Journal: Molecular Therapy

PubMed ID: 41722567

Doi: 10.1016/j.cels.2025.101510

Messenger RNA delivery to islet β cells using conjugated lipid nanoparticles

Authors: Jacob R Enriquez, Zhengjie Zhou, Jennifer B Nelson, Fei Huang, Kayla T Figatner, Advaita Chakraborty, Sarida Pratuangtham, Brian Xi, Sarah C May, Matthew V Tirrell, Sarah A Tersey, Yun Fang, Raghavendra G Mirmira

Journal: Molecular Therapy

PubMed ID: 41722565

Doi: 10.1016/j.xcrm.2026.102634

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Identification of xenobiotics interfering with 5α-reductase (SRD5A2) activity

Authors: Jacek Kędzierski, Rianne E van Diest, Julien A Allard, Andreas M Erharter, Alex Odermatt, Martin Smieko

Journal: Molecular Therapy

PubMed ID: 41722875

Doi: 10.1016/j.toxlet.2026.111859

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Targeting Langerhans cells using a modular mannosylated nucleic acid-based vaccine platform

Authors: Simon Christian Vinther, Antonia Resag, Karina Thao Thu Le, Claudia Christine Zelle-Rieser, Helen Strandt, Mette Galsgaard Malle, Stig Hill Christiansen, Barbara Del Frari, Theresia Stigger, Bastian Schilling, Jonas Wohlfarth, Steffen Thiel, Julián Valero, Patrizia Stoitzner, Jørgen Kjems

Journal: Molecular Therapy

PubMed ID: 41713595

Doi: 10.1016/j.jconrel.2026.114741

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The protein phosphatase 2A-B56α complex regulates N-Myc degradation in neuroblastoma

Authors: Brian D Tran, Irene Peris, Ethan Wurman, Averie Huang, Gabrielle Hodges Onishi, Jiang Hu, Rita A Avelar, Erika A Newman, Analisa DiFeo, Caitlin M O'Connor, Goutham Narla

Journal: Molecular Therapy

PubMed ID: 41707997

Doi: 10.1016/j.jbc.2026.111298

Heterologous vs. homologous vaccine regimens: Sulfated lactosyl archaeol (SLA) archaeosome-adjuvanted SARS-CoV-2 spike protein boost following an mRNA/LNP prime induces robust and balanced immune responses

Authors: Tyler M Renner, Gerard Agbayani, Hiva Azizi, Lise Deschatelets, Renu Dudani, Blair A Harrison, Usha D Hemraz, Roger Koukiekolo, Matthew Stuible, Yves Durocher, Michael J McCluskie, Bassel Akache

Journal: Vaccine

PubMed ID: 41505874

Doi: 10.1016/j.vaccine.2025.128182

Products & Services: Codon Optimization Gene Synthesis

GbWAKL20 Phosphorylates GbNFYB8 to Modulate Verticillium Wilt Resistance in Cotton

Authors: Guilin Wang, Qingxin Si, Zhiguo Chen, Zhe Yu, Zhan Guo, Lu Wang, Weixi Li, Wangzhen Guo

Journal: Advanced Science

PubMed ID: 41521460

Doi: 10.1002/advs.202515724

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