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Missense mutations affecting Ca-coordination in GCAP1 lead to cone-rod dystrophies by altering protein structural and functional properties

Authors: Giuditta Dal Cortivo, Valerio Marino, Francesco Bonì, Mario Milani, Daniele Dell'Orco

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 32650103

Doi: 10.1016/j.bbamcr.2020.118794

Products & Services: PCR Cloning and Subcloning Gene Synthesis

Screening membraneless organelle participants with machine-learning models that integrate multimodal features

Authors: Zhaoming Chen, Chao Hou, Liang Wang, Chunyu Yu, Taoyu Chen, Boyan Shen, Yaoyao Hou, Pilong Li, Tingting Li

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35687670

Doi: 10.1073/pnas.2115369119

Products & Services: Proteins, Expression, Isolation and Analysis

Codon Optimization Using a Recurrent Neural Network

Authors: Dennis R Goulet, Yongqi Yan, Palak Agrawal, Andrew B Waight, Amanda Nga-Sze Mak, Yi Zhu

Journal: J Comput Biol

PubMed ID: 35727687

Doi: 10.1089/cmb.2021.0458

Products & Services: Gene Synthesis

Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K-specific inhibition

Authors: Eric T Baldwin, Matthias Götte, Egor P Tchesnokov, Eddy Arnold, Margit Hagel, Charles Nichols, Pam Dossang, Marieke Lamers, Paul Wan, Stefan Steinbacher, Donna L Romero

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35771941

Doi: 10.1073/pnas.2200260119

Products & Services: Codon Optimization

Comparison of the Immunogenic Properties of Carrying the Mycobacterial Ag85B-ESAT-6 Antigen at Various Cellular Localizations

Authors: Kamilla Wiull, Preben Boysen, Katarzyna Kuczkowska, Lars Fredrik Moen, Harald Carlsen, Vincent G H Eijsink, Geir Mathiesen

Journal: Front Microbiol

PubMed ID: 35722346

Doi: 10.3389/fmicb.2022.900922

Products & Services: Proteins, Expression, Isolation and Analysis

Targeting the interaction of GABA receptors with CaMKII with an interfering peptide restores receptor expression after cerebral ischemia and inhibits progressive neuronal death in mouse brain cells and slices

Authors: Karthik Balakrishnan, Mohammad Hleihil, Musadiq A Bhat, Robert P Ganley, Markus Vaas, Jan Klohs, Hanns Ulrich Zeilhofer, Dietmar Benke