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Nanosized Shikonin Disrupts Tumor-cell Mismatch Repair and Synergizes with Manganese to Sensitize Squamous Carcinoma to Immunotherapy

Authors: Shan Yu, Jingyuan Li, Jie Zhang, Guozhong Zeng, Bin Zeng, Shuyuan Song, Zhentao Lao, Haolin Chen, Zhenfu Wen, Zeyu Yang, Xiang Li, Kan Li, Le Yang, Hong Liu, Lixin Liu, Guiqing Liao, Yongming Chen, Yujie Liang

Journal: ACS Nano

PubMed ID: 40190094

Doi: 10.1021/acsnano.4c17090.

Products & Services: Protein and Antibody Isolation

Cryo-EM structures of the small-conductance Ca2+-activated KCa2.2 channel

Authors: Young-Woo Nam, Dohyun Im, Ana Santa Cruz Garcia, Marios L Tringides, Hai Minh Nguyen, Yan Liu, Razan Orfali, Alena Ramanishka, Grigore Pintilie, Chih-Chia Su, Meng Cui, Diomedes E Logothetis, Edward W Yu, Heike Wulff, K George Chandy, Miao Zhang

Journal: Nat Commun

PubMed ID: 40246884

Doi: /10.1038/s41467-025-59061-1

Products & Services: Gene Synthesis

2A-biohydrogels accelerate diabetic wound healing by promoting M2 macrophage polarization and functionalized mitochondrial transfer to endothelial cells

Authors: Hao Wang, Min Zhou, Yifeng Ruan, Yifei Shen, Ziqi Qin, Xingbo Wu, Huiling Ling, Wushuang Ye, Yongfu Wang, Xueqi Gan

Journal: Chemical Engineering Journal

Doi: 10.1016/j.cej.2025.163130

Products & Services: Custom DNA/RNA Oligos

The Atypical Pectin Methylesterase Family Member PME31 Promotes Seedling Lipid Droplet Utilization

Authors: Sarah Hamade, Melissa S Traver , Bonnie Bartel

Journal: Plant Direct

PubMed ID: 40212536

Doi: doi.org/10.1002/pld3.70054

Products & Services: Catalog Antibodies

Peptide-conjugated alginate fiber: A skeletal muscle regenerative scaffold

Authors: Yajun Li, Yueren Wu, Tong Wu, Can Zhang, Jianwu Dai, Jianping Tang, Lin Li, Liyang Shi

Journal: Carbohydrate Polymers

PubMed ID: 39978892

Doi: 10.1016/j.carbpol.2025.123299

Products & Services: Catalog Peptides

Sequence and taxonomic feature evaluation facilitated the discovery of alcohol oxidases

Authors: Yilei Han, Xuwei Ding, Junjian Tan, Yajuan Sun, Yunjiang Duan, Zheng Liu, Gaowei Zheng, Diannan Lu

Journal: Synthetic and Systems Biotechnology

PubMed ID: 40386440

Doi: doi.org/10.1016/j.synbio.2025.04.014

Products & Services: Molecular Biology Reagents

A chemical radar allows bacteria to detect and kill predators

Authors: Shuaibing Zhang, Kevin Schlabach, Victor Hugo Pérez Carrillo, Anan Ibrahim, Shahran Nayem, Anna Komor, Ruchira Mukherji, Somak Chowdhury, Lisa Reimer, Felix Trottmann, A Corina Vlot, Christian Hertweck, Ute A Hellmich, Pierre Stallforth

Journal: Cell

PubMed ID: 40179883

Doi: 10.1016/j.cell.2025.02.033

Effective extracellular payload release and immunomodulatory interactions govern the therapeutic effect of trastuzumab deruxtecan (T-DXd)

Authors: Li-Chung Tsao, John S. Wang, Xingru Ma, Sirajbir Sodhi, Joey V. Ragusa, Bushangqing Liu, Jason McBane, Tao Wang, Junping Wei, Cong-Xiao Liu, Xiao Yang, Gangjun Lei, Ivan Spasojevic, Ping Fan, Timothy N. Trotter, Michael Morse, Herbert Kim Lyerly & Zachary C. Hartman

Journal: Nature Communications

PubMed ID: 40175391

Doi: 10.1038/s41467-025-58266-8

Products & Services: CRISPR Plasmids

Redox disruption using electroactive liposome coated gold nanoparticles for cancer therapy

Authors: Ying-Chi Chen, Li-Chan Chang, Yan-Ling Liu, Ming-Che Chang, Yin-Fen Liu, Po-Ya Chang, Divinah Manoharan, Wen-Jyun Wang, Jia-Sin Chen, Hsueh-Chun Wang, Wen-Tai Chiu, Wei-Peng Li, Hwo-Shuenn Sheu, Wen-Pin Su & Chen-Sheng Yeh

Journal: Nature Communications

PubMed ID: 40188189

Doi: 10.1038/s41467-025-58636-2

Products & Services: Protein Electrophoresis and Western

The differential effect of SARS-CoV-2 NSP1 on mRNA translation and stability reveals new insights linking ribosome recruitment, codon usage, and virus evolution

Authors: Juan José Berlanga, Tania Matamoros, Miguel Rodríguez Pulido, Margarita Sáiz, Mercedes Núñez Bayón, René Toribio, Iván Ventoso

Journal: Nucleic Acids Research

PubMed ID: 40193709

Doi: 10.1093/nar/gkaf261

Products & Services: PCR Cloning and Subcloning