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Mutant huntingtin induces neuronal apoptosis via derepressing the non-canonical poly(A) polymerase PAPD5

Authors: Zhefan Stephen Chen, Shaohong Isaac Peng, Lok I Leong, Terence Gall-Duncan, Nathan Siu Jun Wong, Tsz Ho Li, Xiao Lin, Yuming Wei, Alex Chun Koon, Junzhe Huang, Jacquelyne Ka-Li Sun, Clinton Turner, Lynette Tippett, Maurice A. Curtis, Richard L. M. Faull, Kin Ming Kwan, Hei-Man Chow, Ho Ko, Ting-Fung Chan, Kevin Talbot, Christopher E. Pearson & Ho Yin Edwin Chan

Journal: Nature Communications

PubMed ID: 40204699

Doi: 10.1038/s41467-025-58618-4

Products & Services: Gene Synthesis

Vibrio MARTX toxin binding of biantennary N-glycans at host cell surfaces

Authors: Jiexi Chen, Felix Goerdeler, Thapakorn Jaroentomeechai, Francisco X S Hernandez, Xiaozhong Wang, Henrik Clausen, Yoshiki Narimatsu, Karla J F Satchell

Journal: SCIENCE ADVANCES

PubMed ID: 40203092

Doi: 10.1126/sciadv.adt0063

Products & Services: Catalog Antibodies

Molecular basis for the assembly of the Vps5-Vps17 SNX-BAR proteins with Retromer

Authors: Kai-En Chen, Vikas A. Tillu, Navin Gopaldass, Sudeshna Roy Chowdhury, Natalya Leneva, Oleksiy Kovtun, Juanfang Ruan, Qian Guo, Nicholas Ariotti, Andreas Mayer & Brett M. Collins

Journal: Nature Communications

PubMed ID: 40234461

Doi: 10.1038/s41467-025-58846-8

Products & Services: Gene Fragments

Mechanism of DNA replication fork breakage and PARP1 hyperactivation during replication catastrophe

Authors: Pedro Ortega, Elodie Bournique, Junyi Li, Ambrocio Sanchez, Gisselle Santiago, Brooke R Harris, Josefine Striepen, John Maciejowski, Abby M Green, Rémi Buisson

Journal: SCIENCE ADVANCES

PubMed ID: 40238882

Doi: 10.1126/sciadv.adu0437

Products & Services: Gene Synthesis

Ara-C suppresses H3 K27–altered spinal cord diffuse midline glioma growth and enhances immune checkpoint blockade sensitivity

Authors: Bo Pang, Yilin Wu, SongYuan An, Yuzhou Chang, Hao Yan, Han Lin, Zheng Zhao, Fan Wu, Qing Chang, Wenqing Jia, Tao Jiang, Yongzhi Wang, Ruichao Chai

Journal: SCIENCE ADVANCES

PubMed ID: 40238864

Doi: 10.1126/sciadv.adu3956

Products & Services: Protein Electrophoresis and Western

Multimeric transcription factor BCL11A utilizes two zinc-finger tandem arrays to bind clustered short sequence motifs

Authors: John R. Horton, Meigen Yu, Jujun Zhou, Melody Tran, Rithvi R. Anakal, Yue Lu, Robert M. Blumenthal, Xiaotian Zhang, Yun Huang, Xing Zhang & Xiaodong Cheng

Journal: Nature Communications

PubMed ID: 40246927

Doi: 10.1038/s41467-025-58998-7

Products & Services: Gene Synthesis

Structural basis of human Mediator recruitment by the phosphorylated transcription factor Elk-1

Authors: Vincent Villeret

Journal: Nature Communications

PubMed ID: 40263353

Doi: 10.1038/s41467-025-59014-8

Products & Services: Gene Synthesis

Engineering aptamer-directed phosphatase recruiting chimeras: a strategy for modulating receptor function and overcoming drug resistance

Authors: Zhilan Zhou, Yichang Liu, Ya Wang, Hang Jiang, Tingting Chen, Yingdi Zhu, Ting Fu, Juan Li

Journal: Nature Communications

PubMed ID: 40280908

Doi: 10.1038/s41467-025-59098-2

Products & Services: Protein Electrophoresis and Western

Inhibiting Chemotherapy Immune Tolerance and Reversing Tumor Microenvironment by Macrophage-Targeted Nanohybrid Systems for Enhancing Tumor Chemo-Immunotherapy

Authors: You-Teng Qin, Zhi-Yong Rao, Jia-Xin An, Shi-Man Zhang, Yu-Zhang Wang, Ting Pan, and Xian-Zheng Zhang

Journal: Advanced Functional Materials

Doi: doi.org/10.1002/adfm.202501954

Products & Services: Recombinant Proteins

Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs

Authors: Canrong Wu, Chao Zhang, Sanshan Jin, James Jiqi Wang, Antao Dai, Jiuyin Xu, Heng Zhang, Xuemei Yang, Xinheng He, Qingning Yuan, Wen Hu, Youwei Xu, Mingwei Wang, Yi Jiang, Dehua Yang, H Eric Xu

Journal: Cell Discov

PubMed ID: 11962085

Doi: 10.1038/s41421-025-00779-z

Products & Services: Catalog Peptides