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Structural insights into Type II-D Cas9 and its robust cleavage activity

Authors: Kangkang Wang, Jiuyu Wang, Xiaoqi Yang, Wei Sun, Gang Sheng, Yanli Wang

Journal: Nature Communications

PubMed ID: 40790018

Doi: 10.1038/s41467-025-62128-8.

Products & Services: Codon Optimization

Expanding the cytokine receptor alphabet reprograms T cells into diverse states

Authors: Yang Zhao, Masato Ogishi, Aastha Pal, Leon L. Su, Pingdong Tao, Hua Jiang, Grayson E. Rodriguez, Xiaojing Chen, Qinli Sun, Lea Wenting Rysavy, Sam Limsuwannarot, Deepa Waghray, Anusha Kalbasi, K. Christopher Garcia

Journal: Nature

PubMed ID: 40804519

Doi: 10.1038/s41586-025-09393-1.

Products & Services: Peptide Synthesis

RNA Pol II inhibition activates cell death independently from the loss of transcription

Authors: Nicholas W Harper, Gavin A Birdsall, Megan E Honeywell, Kelly M Ward, Athma A Pai, Michael J Lee

Journal: Cell

PubMed ID: 40818455

Doi: 10.1016/j.cell.2025.07.034

Products & Services: Peptide Synthesis

The NSP5, ORF6 and NSP13 of SARS-CoV-2 Cooperate to Modulate Inflammatory Cell Death Activation

Authors: Huan Wang, Mengdi Liang, Jing Zhang, Hua Tong, Fenfen Zhang, Ying Liu, Pui Wang, Mengmeng Chang, Fei Han, Siwen Liu, Yongping Lin, Wenjun Song, Rajendra Karki, Peihui Wang, Honglin Chen, Yang Liu, Min Zheng

Journal: Advanced Science

PubMed ID: 40810650

Doi: 10.1002/advs.202503977

Products & Services: Protein and Antibody Isolation

Iron-sulfur clusters in SARS-CoV-2 exoribonuclease and methyltransferase complexes: relevance for viral genome proofreading and capping

Authors: Nunziata Maio, Umberto Terranova, Yan Li, J Martin Bollinger Jr, Carsten Krebs, Tracey A Rouault

Journal: Nature Communications

PubMed ID: 40817372

Doi: 10.1038/s41467-025-62832-5.

Products & Services: Polyclonal Antibody Services

O-GlcNAc transferase plays dual antiviral roles by integrating innate immunity and lipid metabolism

Authors: Hong Dong, Chenxi Liang, Junjie Zhang, Weidong Wu, Nitesh Kumar, Zihao Liu, Yajun Sun, Zhiwei Liao, Xiaolin Cheng, Yanbao Yu, Yong Zhang, Michael J Holtzman, Jianrong Li, Kymberly M Gowdy, Paul G Thomas, Jovica D Badjic, Anjun Ma, Qin Ma, Jacob S Yount, Shan-Lu Liu, Haitao Wen

Journal: Nature Communications

PubMed ID: 40830102

Doi: 10.1038/s41467-025-63085-y.

Products & Services: Catalog Peptides

Highly scalable prefusion-stabilized RSV F vaccine with enhanced immunogenicity and robust protection

Authors: Qingrui Huang, Qingyun Lang, Yao Li, Fengjie Wang, Xiaonan Han, Ling Luo, Xiaomin Duan, Xuerong Cao, Yue Wang, Yu Bai, Yaxin Song, Yanpeng Xu, Lianlian Bian, Chenyan Gao, Linqing Zhao, Jinghua Yan

Journal: Nature Communications

PubMed ID: 40841372

Doi: 10.1038/s41467-025-63084-z.

Products & Services: Gene Synthesis

LYMTACs:chimeric small molecules repurpose lysosomal membrane proteins for target protein relocalization and degradation

Authors: Dhanusha A Nalawansha, Georgios Mazis, Gitte Husemoen, Kate S Ashton, Weixian Deng, Ryan P Wurz, Anh T Tran, Brian A Lanman, Jiansong Xie, Robert G Guenette, Shiqian Li, Christopher E Smith, Suresh Archunan, Manoj K Agnihotram, Arghya Sadhukhan, Rajiv Kapoor, Chris Wilde, Sajjan Koirala, Felipe De Sousa E Melo, Patrick Ryan Potts

Journal: Nature Communications

PubMed ID: 40841368

Doi: 10.1038/s41467-025-63128-4.

Products & Services: Custom Vector Construction

A Dapl1+ subpopulation of naïve CD8 T cells is enriched for memory-lineage precursors

Authors: Adam C Lynch, Kaito A Hioki, Xueting Liang, Iris Thesmar, Julia Cernjul, Xinjian Doris He, Jesse Mager, Wei Cui, Dominique Alfandari, Elena L Pobezinskaya, Leonid A Pobezinsky

Journal: SCIENCE ADVANCES

PubMed ID: 40845112

Doi: 10.1126/sciadv.adx5687

Products & Services: Custom Vector Construction

Structure-guided engineering of type I-F CASTs for targeted gene insertion in human cells

Authors: George D Lampe, Ashley R Liang, Dennis J Zhang, Israel S Fernández, Samuel H Sternberg

Journal: Nature Communications

PubMed ID: 40849322

Doi: 10.1038/s41467-025-63164-0.

Products & Services: Bacterial Expression