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页码: 52/5357 每页显示数量

Combining evidence from human genetic and functional screens to identify pathways altering obesity and fat distribution

Authors: Nikolas A. Baya; Ilknur Sur Erdem; Samvida S. Venkatesh; Saskia Reibe; Philip D. Charles; Elena Navarro-Guerrero; Barney Hill; Frederik H. Lassen; Melina Claussnitzer; Duncan S. Palmer; Cecilia M. Lindgren

Journal: American journal of human genetics

PubMed ID: 40912257

Doi: 10.1016/j.ajhg.2025.08.013

Interplay between malic enzyme 2, de novo serine synthesis, and the malate-aspartate shuttle drives metabolic adaptation in triple-negative breast cancer

Authors: Jin Heon Jeon; Mark D. Slayton; Ben Krinkel; Olamide Animasahun; Ajay Shankaran; Fulei Wuchu; Minal Nenwani; Zackariah Farah; Julia Burke; Abhinav Achreja; Brisilda Nilaj; Kerslee Kohagen; Yi-Hsien Eu; Alyssa Rosenfeld; Mason Collard; Liwei Bao; Xu Cheng; Celina Kleer; Christopher Squire; Kerry Loomes; Deepak Nagrath; Sofia D. Merajver

Journal: Cancer & Metabolism

PubMed ID: 41088330

Doi: 10.1186/s40170-025-00410-5

Insights into next generation sequencing guided antibody selection strategies

Authors: M. Frank Erasmus; Fortunato Ferrara; Sara D Angelo; Laura Spector; Camila Leal-Lopes; Andr A. Teixeira; Jesper S rensen; Suhani Nagpal; Kathryn Perea-Schmittle; Alok Choudhary; William Honnen; David Calianese; Luis Antonio Rodriguez Carnero; Simon Cocklin; Victor Greiff; Abraham Pinter; Andrew R. M. Bradbury

Journal: Scientific REPORTS

PubMed ID: 37884618

Doi: 10.1038/s41598-023-45538-w

Products & Services: Catalog Antibodies

Insights into next generation sequencing guided antibody selection strategies

Journal: Scientific REPORTS

PubMed ID: 37884618

Doi: 10.1038/s41598-023-45538-w

Products & Services: Catalog Antibodies

Protocol for production and characterization of SARS-CoV-2 PL pro in Escherichia coli

Authors: Anna De Falco; Rebecca Greene-Cramer; Ben A. Shurina; Suren Zakian; Thomas B. Acton; Theresa A. Ramelot; Gaetano T. Montelione

Journal: STAR Protocols

PubMed ID: 40682779

Doi: 10.1016/j.xpro.2025.103952

An AI-derived peptide PCa2 suppresses pancreatic cancer growth via modulation of the ErbB/PI3K/AKT/mTOR/MYC signaling axis

Authors: Weimin Zuo; Siyuan Luo; Haixin Qin; Koon Ho Wong; Shirley W. I. Siu; Alexandre K. Tashima; Yehuda G. Assaraf; Hang Fai Kwok

Journal: Cell Communication and Signaling : CCS

PubMed ID: 41957678

Doi: 10.1186/s12964-026-02856-6

Products & Services: Peptide Synthesis

A D-Phenylalanine-Benzoxazole Derivative Reveals the Role of the Essential Enzyme Rv3603c in the Pantothenate Biosynthetic Pathway of Mycobacterium tuberculosis

Authors: Michael J. Pepi; Shibin Chacko; Gary M. Marqus; Vinayak Singh; Zhe Wang; Kyle Planck; Ryan T. Cullinane; Penchala N. Meka; Deviprasad R. Gollapalli; Thomas R. Ioerger; Kyu Y. Rhee; Gregory D. Cuny; Helena I.M. Boshoff; Lizbeth Hedstrom

Journal: ACS Infectious Diseases

PubMed ID: 35015509

Doi: 10.1021/acsinfecdis.1c00461

Guidelines in the Preparation of Fully Synthetic, Human Single-Domain Antibody Phage Display Libraries

Authors: Mark A. Tornetta; Brian P. Whitaker; Olivia M. Cantwell; Peter N. Haytko; Eileen D. Pisors; Fulai Zhou; Mark L. Chiu

Journal: Antibodies

PubMed ID: 40843683

Doi: 10.3390/antib14030071

Development of Pyrimido Pyridazine Analogs through Increased Whole Cell Target Engagement of the Dihydropteroate Synthase Pterin Binding Site in Gram-Negative Bacteria

Authors: Hannah E. Snoke; Stephanie M. Reeve; Suresh Dharuman; Miranda J. Wallace; Victoria C. Loudon; Ying Zhao; John J. Bowling; Patricia A. Murphy; Brett Waddell; Robin B. Lee; J rgen B. Bulitta; Richard E. Lee

Journal: ACS Infectious Diseases

PubMed ID: 41116192

Doi: 10.1021/acsinfecdis.5c00635

T cell cholesterol transport links intestinal immune responses to dietary lipid absorption

Authors: Yajing Gao, John P Kennelly, Xu Xiao, Emily Whang, Alessandra Ferrari, Alexander H Bedard, Julia J Mack, Alexander Nguyen, Sonal Srikanth, Thomas Weston, Lauren F Uchiyama, Whitaker Cohn, Danielle H Cho, Min Sub Lee, Julian Whitelegge, Yousang Gwack, Stephen G Young, Steven J Bensinger, Peter Tontonoz

Journal: Science

PubMed ID: 41066556

Doi: 10.1126/science.adt4169

Products & Services: Recombinant Proteins