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Multivalent S2 subunit vaccines provide broad protection against Clade 1 sarbecoviruses in female mice

Authors: Peter J. Halfmann, Raj S. Patel, Kathryn Loeffler, Atsuhiro Yasuhara, Lee-Ann Van De Velde, Jie E. Yang, Jordan Chervin, Chloe Troxell, Min Huang, Naiying Zheng, Elizabeth R. Wright, Paul G. Thomas, Patrick C. Wilson, Yoshihiro Kawaoka & Ravi S. Kane

Journal: Nature Communications

PubMed ID: 39774966

Doi: 10.1038/s41467-025-55824-y

Products & Services: Custom Vector Construction

Structural and bioinformatics analyses identify deoxydinucleotide-specific nucleases and their association with genomic islands in gram-positive bacteria

Authors: Sofia Mortensen, Stanislava Kuncová, Justin D Lormand, Tanner M Myers, Soo-Kyoung Kim, Vincent T Lee, Wade C Winkler, Holger Sondermann

Journal: Nucleic Acids Research

PubMed ID: 39778863

Doi: 10.1093/nar/gkae1235

Products & Services: Gene Synthesis

Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity

Authors: Mingjiong Zhang, Jiahua Cui, Haoyan Chen, Yifan Cheng, Qiaoyu Chen, Feng Zong, Xiao Lu, Lang Qin, Yu Han, Xingwang Kuai, Yuxing Zhang, Minjie Chu, Shuangshuang Wu & Jianqing Wu

Journal: Nature Communications

PubMed ID: 39805872

Doi: 10.1038/s41467-025-56002-w

Products & Services: Protein and Antibody Reagents

Scale-free Spatio-temporal Correlations in Conformational Fluctuations of Intrinsically Disordered Proteins

Authors: Haoyu Song, Jian Cui, Guorong Hu, Long Xiong, Yanee Wutthinitikornkit, Hai Lei, Jingyuan Li

Journal: Advanced Science

PubMed ID: 39807013

Doi: 10.1002/advs.202412989

Products & Services: Gene Synthesis

Recombinant expression systems for production of stabilised virus-like particles as next-generation polio vaccines

Authors: Lee Sherry, Mohammad W. Bahar, Claudine Porta, Helen Fox, Keith Grehan, Veronica Nasta, Helen M. E. Duyvesteyn, Luigi De Colibus, Johanna Marsian, Inga Murdoch, Daniel Ponndorf, Seong-Ryong Kim, Sachin Shah, Sarah Carlyle, Jessica J. Swanson, Sue Matthews, Clare Nicol, George P. Lomonossoff, Andrew J. Macadam, Elizabeth E. Fry, David I. Stuart, Nicola J. Stonehouse & David J. Rowlands

Journal: Nature Communications

PubMed ID: 39827284

Doi: 10.1038/s41467-025-56118-z

Products & Services: Gene Fragments

Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer

Authors: Ryan Blawski; Bujamin H. Vokshi; Xinyu Guo; Srushti Kittane; Mirna Sallaku; Wanlu Chen; Martina Gjyzari; Tony Cheung; Yuhan Zhang; Christopher Simpkins; Weiqiang Zhou; Amanda Kulick; Peihua Zhao; Meihan Wei; Pranavkrishna Shivashankar; Tatiana Prioleau; Pedram Razavi; Richard Koche; Vito W. Rebecca; Elisa de Stanchina; Pau Castel; Ho Man Chan; Maurizio Scaltriti; Emiliano Cocco; Hongkai Ji; Minkui Luo; Eneda Toska

Journal: Cell Reports

PubMed ID: 38700982

Doi: 10.1016/j.celrep.2024.114174

Products & Services: Peptide Synthesis

Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer

Journal: Cell Reports

PubMed ID: 38700982

Doi: 10.1016/j.celrep.2024.114174

Products & Services: Peptide Synthesis

Deep mutational scanning and machine learning for the analysis of antimicrobial-peptide features driving membrane selectivity

Authors: Justin R. Randall; Luiz C. Vieira; Claus O. Wilke; Bryan W. Davies

Journal: Nature biomedical engineering

PubMed ID: 39085646

Doi: 10.1038/s41551-024-01243-1

Products & Services: Peptide Synthesis

Deep mutational scanning and machine learning for the analysis of antimicrobial-peptide features driving membrane selectivity

Authors: Justin R. Randall; Luiz C. Vieira; Claus O. Wilke; Bryan W. Davies

Journal: Nature biomedical engineering

PubMed ID: 39085646

Doi: 10.1038/s41551-024-01243-1

Products & Services: Peptide Synthesis

Probing SARS-CoV-2 membrane binding peptide via single-molecule AFM-based force spectroscopy

Authors: Qingrong Zhang, Raissa S. L. Rosa, Ankita Ray, Kimberley Durlet, Gol Mohammad Dorrazehi, Rafael C. Bernardi & David Alsteens

Journal: Nature Communications

PubMed ID: 39747000

Doi: 10.1038/s41467-024-55358-9

Products & Services: Peptide Synthesis