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FcRn-silencing of IL-12Fc prevents toxicity of local IL-12 therapy and prolongs survival in experimental glioblastoma

Authors: Michal Beffinger, Linda Schellhammer, Betül Taskoparan, Sereina Deplazes, Ulisse Salazar, Nazanin Tatari, Frauke Seehusen, Leopold von Balthazar, Carl Philipp Zinner, Sabine Spath, Tala Shekarian, Marie-Françoise Ritz, Marta McDaid, Pascal Egloff, Iwan Zimmermann, Hideho Okada, E Sally Ward, Jack Rohrer, Markus A Seeger, Thorsten Buch, Gregor Hutter, Johannes Vom Berg

Journal: Nature Communications

PubMed ID: 40404625

Doi: 10.1038/s41467-025-59971-0

Products & Services: Protein Electrophoresis and Western

The ALX4 dimer structure provides insight into how disease alleles impact function

Authors: Brittany Cain , Zhenyu Yuan , Evelyn Thoman, Rhett A Kovall , Brian Gebelein

Journal: Nature Communications

PubMed ID: 40410151

Doi: 10.1038/s41467-025-59728-9

Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites

Authors: Thomas H Ambrosi, Sahar Taheri, Kun Chen, Rahul Sinha, Yuting Wang, Ethan J Hunt, L Henry Goodnough, Matthew P Murphy, Holly M Steininger, Malachia Y Hoover, Franco Felix, Kelly C Weldon, Lauren S Koepke, Jan Sokol, Daniel Dan Liu, Liming Zhao, Stephanie D Conley, Wan-Jin Lu, Maurizio Morri, Norma F Neff, Noelle L Van Rysselberghe, Erika E Wheeler, Yongheng Wang, J Kent Leach, Augustine Saiz, Aijun Wang, George P Yang, Stuart Goodman, Julius A Bishop, Michael J Gardner, Derrick C Wan, Irving L Weissman, Michael T Longaker, Debashis Sahoo, Charles K F Chan

Journal: Cell Stem Cell

PubMed ID: 40118065

Doi: 10.1016/j.stem.2025.02.013

Products & Services: Peptide Synthesis

Ferritin From Striped Stem Borer (Chilo suppressalis) Oral Secretion Acts as an Effector Helping to Maintain Iron Homoeostasis and Impair Defenses in Rice

Authors: Shan Yu, Shuai Li, Jing Li, Chen-Yang Wang, Lei Yang, Jing Li, Yue Meng, Xin-Yang Tan, Mao-Feng Jing, Guang-Hua Luo, Ji-Chao Fang, Rui Ji

Journal: PLANT CELL AND ENVIRONMENT

PubMed ID: 39812459

Doi: 10.1111/pce.15386

Products & Services: Polyclonal Antibody Services

Fe(III)−H2O2 as an Alternative Oxidant for Catalytic Sulfoxidation in Cytochrome P450 Enzymes: Combined Theoretical and Experimental Evidence

Authors: Musen Li, Langxing Liao, Zhihui Jiang, Zongyu Bao, Shengbiao Ji, Binju Wang

Journal: ACS catalysis

Doi: doi.org/10.1021/acscatal.5c01673

Products & Services: Gene Synthesis Codon Optimization

A general assay platform to study protein pharmacology using ligand-dependent structural dynamics

Authors: Daniel A Ciulla, Patricia K Dranchak, Mahesh Aitha, Renier H P van Neer, Divia Shah, Ravi Tharakan, Kelli M Wilson, Yuhong Wang, John C Braisted, James Inglese

Journal: nature COMMUNICATION

PubMed ID: 40346061

Doi: 10.1038/s41467-025-59658-6

Products & Services: Custom DNA/RNA Oligos

Deletion of the Envelope gene attenuates SARS-CoV-2 infection by altered Spike localization and increased cell-to-cell transmission

Authors: Hannah L. Fischer; Christopher Kline; W. Paul Duprex; Kevin R. McCarthy; Simon C. Watkins; James F. Conway; Zandrea Ambrose

Journal: biorxiv

PubMed ID: 40475451

Doi: 10.1101/2025.05.20.655126

A yeast-based system to study SARS-CoV-2 M pro structure and to identify nirmatrelvir resistant mutations

Authors: Jin Ou; Eric M. Lewandowski; Yanmei Hu; Austin A. Lipinski; Ryan T. Morgan; Lian M.C. Jacobs; Xiujun Zhang; Melissa J. Bikowitz; Paul Langlais; Haozhou Tan; Jun Wang; Yu Chen; John S. Choy

Journal: research square

PubMed ID: 36052369

Doi: 10.21203/rs.3.rs-1942964/v1

Products & Services: Catalog Antibodies

A yeast-based system to study SARS-CoV-2 M pro structure and to identify nirmatrelvir resistant mutations

Authors: Jin Ou; Eric M. Lewandowski; Yanmei Hu; Austin A. Lipinski; Ryan T. Morgan; Lian M.C. Jacobs; Xiujun Zhang; Melissa J. Bikowitz; Paul Langlais; Haozhou Tan; Jun Wang; Yu Chen; John S. Choy

Journal: research square

PubMed ID: 36052369

Doi: 10.21203/rs.3.rs-1942964/v1

Products & Services: Catalog Antibodies

A fluorescence-based assay for measuring polyamine biosynthesis aminopropyl transferase mediated catalysis

Authors: Pallavi Singh; Jae-Yeon Choi; Weiwei Wang; Tukiet T. Lam; Philip Lechner; Christopher D. Vanderwal; Sovitj Pou; Aaron Nilsen; Choukri Ben Mamoun

Journal: The Journal of Biological Chemistry

PubMed ID: 39342998

Doi: 10.1016/j.jbc.2024.107832