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EGF‑IL2 bispecific and bivalent EGF fusion toxin efficacy against syngeneic head and neck cancer mouse models

Authors: Yue Qiu , Zeng Qi , Zhaohui Wang , Yu Cao , Ling Lu , Huiping Zhang , David Mathes , Elizabeth A Pomfret , Shi-Long Lu , Zhirui Wang

Journal: Oncol Rep

PubMed ID: 36579667

Doi: 10.3892/or.2022.8474

Products & Services: Gene Synthesis

Structural insight into the Scribble PDZ domains interaction with the oncogenic Human T-cell lymphotrophic virus-1 (HTLV-1) Tax1 PBM

Authors: Airah Javorsky, Janesha C Maddumage, Emily R R Mackie, Tatiana P Soares da Costa, Patrick O Humbert, Marc Kvansakul

Journal: The FEBS journal

PubMed ID: 36029163

Doi: 10.1111/febs.16607

Products & Services: Peptide Synthesis

Synthetic E2-Ub-nucleosome conjugates for studying nucleosome ubiquitination

Authors: Huasong Ai, Zebin Tong, Zhiheng Deng, Jiakun Tian, Liying Zhang, Maoshen Sun, Yunxiang Du, Ziyu Xu, Qiang Shi, Lujun Liang, Qingyun Zheng, Jia-Bin Li, Man Pan, and Lei Liu

Journal: Chem

Doi: 10.1016/j.chempr.2023.01.012

Products & Services: Gene Synthesis

Two pan-SARS-CoV-2 nanobodies and their multivalent derivatives effectively prevent Omicron infections in mice

Authors: Honghui Liu, Lili Wu, Bo Liu, Ke Xu, Wenwen Lei, Jianguo Deng, Xiaoyu Rong, Pei Du, Lebing Wang, Dongbin Wang, Xiaolong Zhang, Chao Su, Yuhai Bi, Hua Chen, William J Liu, Jianxun Qi, Qingwei Cui, Shuhui Qi, Ruiwen Fan, Jingkun Jiang, Guizhen Wu, George F Gao, Qihui Wang

Journal: Cell reports. Medicine

PubMed ID: 36702124

Doi: 10.1016/j.xcrm

Products & Services: Gene Synthesis

Insights into the oligomeric structure of the HIV-1 Vpu protein

Authors: Saman Majeed, Oluwatosin Adetuyi, Peter P Borbat, Md Majharul Islam, Olamide Ishola, Bo Zhao, Elka R Georgieva

Journal: J Struct Biol

PubMed ID: 36796461

Doi: 10.1016/j.jsb.2023.107943

Products & Services: Molecular Biology Reagents

The endogenous repertoire harbors self-reactive CD4 T cell clones that adopt a follicular helper T cell-like phenotype at steady state

Authors: Victoria Lee, Donald M Rodriguez, Nicole K Ganci, Sharon Zeng, Junting Ai, Jaime L Chao, Matthew T Walker, Christine H Miller, David E J Klawon, Mary H Schoenbach, Domenick E Kennedy, Mark Maienschein-Cline, Nicholas D Socci, Marcus R Clark, Peter A Savage

Journal: Nat Immunol

PubMed ID: 36759711

Doi: 10.1038/s41590-023-01425-0

Products & Services: Molecular Biology Reagents

Elephant TP53-RETROGENE 9 induces transcription-independent apoptosis at the mitochondria

Authors: Aidan J Preston, Aaron Rogers, Miranda Sharp, Gareth Mitchell, Cristhian Toruno, Brayden B Barney, Lauren N Donovan, Journey Bly, Ryan Kennington, Emily Payne, Anthony Iovino, Gabriela Furukawa, Rosann Robinson, Bahar Shamloo, Matthew Buccilli, Rachel Anders, Sarah Eckstein, Elizabeth A Fedak, Tanner Wright, Carlo C Maley, Wendy K Kiso, Dennis Schmitt, David Malkin, Joshua D Schiffman, Lisa M Abegglen

Journal: Cell Death Discov

PubMed ID: 36797268

Doi: 10.1038/s41420-023-01348-7

Products & Services: Molecular Biology Reagents

Celastrol alleviates oxidative stress induced by multi-walled carbon nanotubes through the Keap1/Nrf2/HO-1 signaling pathway

Authors: Tao-Lin Qing, Lang Yan, Shao-Kang Wang, Xiao-Yu Dai, Li-Jun Ren, Ji-Qian-Zhu Zhang, Wen-Jing Shi, Xiao-Fang Zhang, Mei-Tang Wang, Ji-Kuai Chen, Jiang-Bo Zhu

Journal: Ecotoxicol Environ Saf

PubMed ID: 36774793

Doi: 10.1016/j.ecoenv.2023.114623

Products & Services: Molecular Biology Reagents

Synthesis of Bispecific Antibody Conjugates Using Functionalized Poly-ADP-ribose Polymers

Authors: Qinqin Cheng, Xiao-Nan Zhang, Jiawei Li, Jingwen Chen, Yiling Wang, Yong Zhang

Journal: Biochemistry

PubMed ID: 36821831

Doi: 10.1021/acs.biochem.2c00718

Products & Services: Molecular Biology Reagents

Engineered antibody cytokine chimera synergizes with DNA-launched nanoparticle vaccines to potentiate melanoma suppression

Authors: Nicholas J Tursi, Ziyang Xu, Michaela Helble, Susanne Walker, Kevin Liaw, Neethu Chokkalingam, Toshitha Kannan, Yuanhan Wu, Edgar Tello-Ruiz, Daniel H Park, Xizhou Zhu, Megan C Wise, Trevor R F Smith, Sonali Majumdar, Andrew Kossenkov, Daniel W Kulp, David B Weiner

Journal: Front Immunol

PubMed ID: 36911698

Doi: 10.3389/fimmu.2023.1072810

Products & Services: Molecular Biology Reagents