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The combined action of the intracellular regions regulates FGFR2 kinase activity

Authors: Chi-Chuan Lin , Lukasz Wieteska , Guillaume Poncet-Montange , Kin Man Suen , Stefan T Arold , Zamal Ahmed , John E Ladbury

Journal: Commun Biol .

PubMed ID: 37452126

Doi: 10.1038/s42003-023-05112-6

Products & Services: Peptide Synthesis

Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival Bcl-2 family proteins

Authors: Haolan Wang , Ming Guo , Hudie Wei , Yongheng Chen

Journal: Comput Struct Biotechnol J .

PubMed ID: 37560128

Doi: 10.1016/j.csbj.2023.07.017

Products & Services: Peptide Synthesis

Development of miniature base editors using engineered IscB nickase

Authors: Dingyi Han , Qingquan Xiao , Yifan Wang , Hainan Zhang , Xue Dong , Guoling Li , Xiangfeng Kong , Shihao Wang , Jinhui Song , Weihong Zhang , Jingxing Zhou , Lanting Bi , Yuan Yuan , Linyu Shi , Na Zhong , Hui Yang , Yingsi Zhou

Journal: Nat Methods .

PubMed ID: 37231266

Doi: 10.1038/s41592-023-01898-9

Products & Services: Gene Synthesis

Manganese-based microcrystals equipped with Ythdf1-targeted biomimeticnanovaccines for reinforced dendritic cell spatiotemporal orchestration

Authors: Feng Liu , Lulu Tan, Zheng Dai , Yang Wang , Lei Huang , Yang Zhang , Qian Cheng , Xin Li , Miao-Deng Liu, Lin Wang, Zheng Wang

Journal: Nano Today

Doi: 10.1016/j.nantod.2023.102112

Products & Services: DNA Sequencing

Biomimetic Nanofibrillar Hydrogel with Cell-Adaptable Network for Enhancing Cellular Mechanotransduction, Metabolic Energetics, and Bone Regeneration

Authors: Xian Xie ， Zhuo Li , Xuefeng Yang , Boguang Yang , Zhixian Zong , Xuemei Wang , Liting Duan , Sien Lin , Gang Li , Liming Bian

Journal: J Am Chem Soc

PubMed ID: 37428960

Doi: 10.1021/jacs.3c02210

Products & Services: Peptide Synthesis

A Novel Bispecific Antibody for EpCAM-Directed Inhibition of the CD73/Adenosine Immune Checkpoint in Ovarian Cancer

Authors: Emily Maria Ploeg, Isabel Britsch, Anne Paulien van Wijngaarden, Xiurong Ke, Mark Alexander Johannes Martinus Hendriks, Douwe Freerk Samplonius, Wijnand Helfrich

Journal: Cancers (Basel)

PubMed ID: 37509310

Doi: 10.3390/cancers15143651

Products & Services: Gene Synthesis

The structure and mechanism of action of a distinct class of dicistrovirus intergenic region IRESs

Authors: Irina S Abaeva , Christina Young , Reid Warsaba , Nadiyah Khan , Lan Vy Tran , Eric Jan , Tatyana V Pestova , Christopher U T Hellen

Journal: Nucleic Acids Res .

PubMed ID: 37427788

Doi: 10.1093/nar/gkad569

Products & Services: Polyclonal Antibody Services Gene Synthesis

Network pharmacology, molecular docking and experimental verification of the mechanism of huangqi-jixuecao herb pair in treatment of peritoneal fibrosis

Authors: Huibo Dai , Yun Shan , Manshu Yu ， Funing Wang , Ziren Zhou , Jinyi Sun , Li Sheng , Liyan Huang , Meixiao Sheng

Journal: J Ethnopharmacol .

PubMed ID: 37437794

Doi: 10.1016/j.jep.2023.116874

Products & Services: Protein and Antibody Isolation

Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity

Authors: Hudie Wei , Haolan Wang , Genxin Wang , Lingzhi Qu , Longying Jiang , Shuyan Dai , Xiaojuan Chen , Ye Zhang , Zhuchu Chen , Youjun Li , Ming Guo , Yongheng Chen

Journal: Nat Commun .

PubMed ID: 37463921

Doi: 10.1038/s41467-023-40087-2

Products & Services: Protein and Antibody Isolation

The ubiquitin-protein ligase MIEL1 localizes to peroxisomes to promote seedling oleosin degradation and lipid droplet mobilization

Authors: Melissa S Traver , Bonnie Bartel

Journal: Proc Natl Acad Sci U S A .

PubMed ID: 37410814

Doi: 10.1073/pnas.2304870120

Products & Services: Gene Synthesis