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siRNA-mediated mismatch repair disruption synergizes with oxaliplatin to restore immune surveillance in microsatellite-stable colorectal cancer

Authors: Jing Ni, Guantao He, Hongwei Wang, Yao Qin, Jianping Guo, Yuhang Wang, Keqian Du, Di Zhang, Yanxin Luo, Jiang Xia, Yingjie Li, Lin-Ping Wu

Journal: Molecular cancer

Doi: doi.org/10.1186/s12943-026-02752-0

Products & Services: Custom mRNA synthesis

Neurabin I haploinsufficiency disrupts ion channel regulation and synaptic maturation in human cortical neurons in neurodevelopmental disorders

Authors: Binte Zehra, Nesrin Mohamed, Richa Tambi, Muhammad Faizan, Dharana Satsangi, Alexander D Giddey, Gilles Bru-Mercier, Ahmad Farhat, Nesreen K Al-Jezawi, Muhammad Kumail, Nasna Nassir, Bipin Balan, Noor Kosaji, Mariam Eldesouky, Talal Al Yazeedi, Shuhd BinEshaq, Suhana Shiyas, Nidhina Vinod, Saif S Alqassim, Awab Ahmed, Mohammad Amiruddin Hashmi, Nelson C Soares, Marc Woodbury-Smith, Stefan S Du Plessis, Dimitri J Stavropoulos, Stephen W Scherer, Alawi Alsheikh-Ali, Reem Khalil, Mauro Pessia, Maria Cristina D'Adamo, Bakhrom K Berdiev, Mohammed Uddin

Journal: Molecular Psychiatry

PubMed ID: 42603820

Doi: 10.1038/s41380-026-03818-7

Products & Services: PCR Cloning and Subcloning

A non-classical biosynthetic route enables tocopherol synthesis in bacteria

Authors: Yang Zhang, Zhizhen Li, Lichuang Cao, Yan Wang, Junyi Wang, Haofeng Chen, Wenhao Li, Xinyu Gao, Qingchen Li, Zhengxin Chen, Kaixuan Xu, Xiangpeng Yang, Xiangrui Wu, Jintao Luo, Jianzhong Liu, Jifeng Yuan

Journal: nature metabolism

PubMed ID: 42509462

Doi: 10.1038/s42255-026-01576-y

Products & Services: Codon Optimization

RNA synthesis and substrate analog inhibition in the CCHFV polymerase

Authors: Hengxia Jia, Bo Tang, Shunli Liu, Xin Wen, Fan Wu, Xiao Hu, Hu Zhou, Tingting Chong, Lincan Lv, Qiaojie Liu, Guibo Rao, Mingyu Wei, Xuping Jing, Sheng Cao, Fei Deng, Zhihong Hu, Bo Shu, Rui Gong, Jiqin Wu, Manli Wang, Peng Gong

Journal: Nature

Doi: 10.1038/s41586-026-10913-w

Products & Services: PCR Cloning and Subcloning

Sub1 contributes to heart failure with preserved ejection fraction driven by aging in mice

Authors: Di Zhao, Ling Lin, Yufei Zhou, Jiaying Wu, Ran Xu, Linnan Li, Xiaoxue Zhang, Hong Lin, Jienan Wang, Kunming Dai, Zhiwen Ding, Pan Gao, Jian Wu, Yunzeng Zou

Journal: Nature Communications

PubMed ID: 42402618

Doi: 10.1038/s41467-026-75237-9

Products & Services: Peptide Synthesis

A flexible antimicrobial peptide achieves pathogen selectivity through lipid-dependent membrane engagement

Authors: Jia-Tao Guo, Tian-Zhu Sun, Yuan-He Wang, Jiang-Miao Hu

Journal: antimicrobials and resistance

Doi: 10.1038/s44259-026-00253-0

Products & Services: Peptide Synthesis

Activation-induced SLC7A1 expression enhances T cell sensitivity to cGAMP-mediated STING signaling

Authors: Valentino Sudaryo, Dayanne R Carvalho, Jacqueline A Carozza, Xujun Cao, Courtney Kernick, Anthony F Cordova, J Michelle Lee, Theodore L Roth, Lingyin Li

Journal: Cell reports

PubMed ID: 42329763

Doi: 10.1016/j.celrep.2026.117580

The immune protection of OMP16-specific IgM against Brucella infection

Authors: Yunyi Zhai, Kaihui Sun, Ye Yuan, Gawa Wudong, Shuan Qu, Yaxin Li, Yuanhao Yang, XiaoFang Liu, Dong Zhou, Wei Liu, Yaping Jin, Aihua Wang

Journal: BMC Biology

PubMed ID: 42458412

Doi: 10.1186/s12915-026-02682-9

Products & Services: Peptide Synthesis

Description of the rate-limiting hydrogen tunneling mechanism for plant 9- and 13-lipoxygenases

Authors: Alex Kockler, Katherine Ray, Jordan King, Eric Anderson, Joi Walker, Nathaniel Gilbert, Patrick Horn, Adam R Offenbacher

Journal: Protein Science

PubMed ID: 42227275

Doi: 10.1002/pro.70647

Products & Services: Gene Synthesis

Synthetic promoters developed through a site-specific integration system enhance antibody expression in fed-batch culture

Authors: Liyun Yue, Hao Li, Songtao Zhou

Journal: Engineering in Life Sciences

PubMed ID: 42781470

Doi: 10.48130/els-0026-0004

Products & Services: Gene Synthesis