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Dissecting a two-domain alginate lyase of family PL6 reveals a mechanistic basis for substrate specificity and enzyme activity

Authors: Mikkel Madsen; Mette E. R nne; Agnes B. Petersen; Tobias Tandrup; Bo Pilgaard; Jesper Holck; Finn L. Aachmann; Casper Wilkens; Leesa J. Klau; Birte Svensson

Journal: The Journal of Biological Chemistry

PubMed ID: 41638429

Doi: 10.1016/j.jbc.2026.111227

Bile salt hydrolase catalyses formation of amine-conjugated bile acids

Authors: Bipin Rimal, Stephanie L Collins, Ceylan E Tanes, Edson R Rocha, Megan A Granda, Sumeet Solanki, Nushrat J Hoque, Emily C Gentry, Imhoi Koo, Erin R Reilly, Fuhua Hao, Devendra Paudel, Vishal Singh 11, Tingting Yan 12, Min Soo Kim 2, Kyle Bittinger 3, Joseph P Zackular 13 14, Kristopher W Krausz 12, Dhimant Desai 15, Shantu Amin 15, James P Coleman 4, Yatrik M Shah 5, Jordan E Bisanz 2 16, Frank J Gonzalez 12, John P Vanden Heuvel 1 17, Gary D Wu 18, Babette S Zemel 3, Pieter C Dorrestein 7 8, Emily E Weinert 2 6, Andrew D Patterson 19 20 21

Journal: Nature

PubMed ID: 38326609

Doi: 10.1038/s41586-023-06990-w

Products & Services: Gene Synthesis

Harnessing eukaryotic retroelement proteins for transgene insertion into human safe-harbor loci

Authors: Xiaozhu Zhang, Briana Van Treeck, Connor A. Horton, Jeremy J. R. McIntyre, Sarah M. Palm, Justin L. Shumate & Kathleen Collins

Journal: Nat Biotechnol

PubMed ID: 38379101

Doi: 10.1038/s41587-024-02137-y

Products & Services: Plasmid DNA Preparation

Disordered regions mediate the interaction of p53 and MRE11

Authors: Sinem Usluer , Markus Galhuber , Yukti Khanna , Benjamin Bourgeois , Emil Spreitzer , Helene Michenthaler, Andreas Prokesch, Tobias Madl

Journal: Cell Research

PubMed ID: 38123020

Doi: 10.1016/j.bbamcr.2023.119654

Products & Services: Custom Vector Construction

Biomimetic bacteria-derived nanoclusters enhance ferroptosis cancer immunotherapy through synergistic CRISPR-photothermo modulation

Authors: Xiuhua Pan , Jie Yang , Ruixin Kang , Jun Zhang , Zongwei Hu , Ning Yang , Zengyi Liu , Zengguang Jia , Xiawei Zhou , Qi Shen

Journal: Nano Today

Doi: 10.1016/j.nantod.2024.102213

Products & Services: CRISPR Services

Bicistronic expression of nuclear transgenes in Chlamydomonas reinhardtii

Authors: Nick Jacobebbinghaus, Kyle J Lauersen, Olaf Kruse, Thomas Baier

Journal: The Plant Journal

PubMed ID: 38415961

Doi: 10.1111/tpj.16677

Products & Services: Gene Synthesis

Dissecting a two-domain alginate lyase of family PL6 reveals a mechanistic basis for substrate specificity and enzyme activity

Authors: Mikkel Madsen; Mette E. R nne; Agnes B. Petersen; Tobias Tandrup; Bo Pilgaard; Jesper Holck; Finn L. Aachmann; Casper Wilkens; Leesa J. Klau; Birte Svensson

Journal: The Journal of Biological Chemistry

PubMed ID: 41638429

Doi: 10.1016/j.jbc.2026.111227

Dissecting a two-domain alginate lyase of family PL6 reveals a mechanistic basis for substrate specificity and enzyme activity

Authors: Mikkel Madsen; Mette E. R nne; Agnes B. Petersen; Tobias Tandrup; Bo Pilgaard; Jesper Holck; Finn L. Aachmann; Casper Wilkens; Leesa J. Klau; Birte Svensson

Journal: The Journal of Biological Chemistry

PubMed ID: 41638429

Doi: 10.1016/j.jbc.2026.111227

SPR spectroscopic analysis of myosin binding to wild type and mutant UNC45B

Authors: Silvana Valdebenito, Eliseo Eugenin, Andres Oberhauser

Journal: MicroPubl Biol

PubMed ID: 38404916

Doi: 10.17912/micropub.biology.001131

Products & Services: Recombinant Proteins

Essential functions of Inositol hexakisphosphate (IP6) in Murine Leukemia Virus replication

Authors: Banhi Biswas, Kin Kui Lai, Harrison Bracey, Siddhartha A K Datta, Demetria Harvin, Gregory A Sowd, Christopher Aiken, Alan Rein

Journal: biorxiv

PubMed ID: 38464197

Doi: 10.1101/2024.02.27.581940

Products & Services: Protein and Antibody Isolation