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Identification of a Fully Human Antibody VH Domain Targeting Anaplastic Lymphoma Kinase (ALK) with Applications in ALK-Positive Solid Tumor Immunotherapy

Authors: Chuan Chen, Zehua Sun, Zening Wang, Seungmin Shin, Abigail Berrios, John W Mellors, Dimiter S Dimitrov, Wei Li

Journal: Antibodies (Basel)

PubMed ID: 38804307

Doi: 10.3390/antib13020039

Products & Services: Protein and Antibody Isolation

Functional Analysis of the Major Pilin Proteins of Type IV Pili in CGMH010

Authors: Yi-Ywan M Chen, Yuan-Chen Yang, Hui-Ru Shieh, Yu-Juan Lin, Wan-Ju Ke, Cheng-Hsun Chiu

Journal: Int J Mol Sci

PubMed ID: 38791440

Doi: 10.3390/ijms25105402

Products & Services: Gene Synthesis

Structural basis for selectivity and antagonism in extracellular GPCR-nanobodies

Authors: Roman R Schlimgen, Francis C Peterson, Raimond Heukers, Martine J Smit, John D McCorvy, Brian F Volkman

Journal: Nat Commun

PubMed ID: 38816420

Doi: 10.1038/s41467-024-49000-x

Products & Services: Molecular Biology Reagents

Tardigrade secretory proteins protect biological structures from desiccation

Authors: Samuel Lim, Charles B Reilly, Zeina Barghouti, Benedetto Marelli, Jeffrey C Way, Pamela A Silver

Journal: Commun Biol

PubMed ID: 38796644

Doi: 10.1038/s42003-024-06336-w

Products & Services: Protein and Antibody Isolation

MiR-30a-5p isoform -1|1 promotes the progression of gastric cancer by inhibiting TMEM66 and reducing intratumoral cytotoxic T cells

Authors: Yanmiao Dai, Yudong Xu, Jie Shen, Caihong Hu, Xiaoli Li, Yongyu Chen, Yao Liu, Duanmin Hu

Journal: Exp Cell Res

PubMed ID: 38802035

Doi: 10.1016/j.yexcr.2024.114099

Products & Services: Custom DNA/RNA Oligos

Dexmedetomidine enhances Mitophagy via PINK1 to alleviate hippocampal neuronal Pyroptosis and improve postoperative cognitive dysfunction in elderly rat

Authors: Yayu Chen, Gen Wei, Lieliang Zhang, Xiaojin Feng, Enjun Lei

Journal: Exp Neurol

PubMed ID: 38823674

Doi: 10.1016/j.expneurol.2024.114842

Products & Services: Gene Synthesis

Computational design of generalist cyclopropanases with stereodivergent selectivity

Authors: Zhuofan Shen; Mary G. Siriboe; Xinkun Ren; Thakshila Dayananda; Jermaine L. Jenkins; Sagar D. Khare; Rudi Fasan

Journal: Nature Communications

PubMed ID: 41587967

Doi: 10.1038/s41467-026-68327-1

Computational design of generalist cyclopropanases with stereodivergent selectivity

Authors: Zhuofan Shen; Mary G. Siriboe; Xinkun Ren; Thakshila Dayananda; Jermaine L. Jenkins; Sagar D. Khare; Rudi Fasan

Journal: Nature Communications

PubMed ID: 41587967

Doi: 10.1038/s41467-026-68327-1

Nuclear Magnetic Resonance based fragment screen of the E3 ligase Fem 1 homolog B

Authors: Jade M. Katinas; Kangsa Amporndanai; Ashley J. Taylor; Kristie L. Rose; Peter C. Gareiss; Roberto A. Crespo; Jason Phan; Alex G. Waterson; Stephen W. Fesik

Journal: Protein science : a publication of the Protein Society

PubMed ID: 41229306

Doi: 10.1002/pro.70365

MiR-574-5p activates human TLR8 to promote autoimmune signaling and lupus

Authors: Tao Wang, Dan Song, Xuejuan Li, Yu Luo, Dianqiang Yang, Xiaoyan Liu, Xiaodan Kong, Yida Xing, Shulin Bi, Yan Zhang, Tao Hu, Yunyun Zhang, Shuang Dai, Zhiqiang Shao, Dahan Chen, Jinpao Hou, Esteban Ballestar, Jianchun Cai, Feng Zheng, James Y Yang

Journal: Cell Commun Signal

PubMed ID: 38589923

Doi: 10.1186/s12964-024-01601-1

Products & Services: Peptide Synthesis