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Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1

Authors: Callum Beach; David MacLean; Dominika Majorova; Stavros Melemenidis; Dhanya K. Nambiar; Ryan K. Kim; Gabriel N. Valbuena; Silvia Guglietta; Carsten Krieg; Mahnaz Darvish-Damavandi; Tatsuya Suwa; Alistair Easton; Lily V.S. Hillson; Ashley K. McCulloch; Ross K. McMahon; Kathryn Pennel; Joanne Edwards; Sean M. O Cathail; Campbell S. Roxburgh; Enric Domingo; Eui Jung Moon; Dadi Jiang; Yanyan Jiang; Qingyang Zhang; Albert C. Koong; Trent M. Woodruff; Edward E. Graves; Tim Maughan; Simon J.A. Buczacki; Manuel Stucki; Quynh-Thu Le; Simon J. Leedham; Amato J. Giaccia; Monica M. Olcina

Journal: The Journal of clinical investigation

PubMed ID: 37824211

Doi: 10.1172/JCI168277

Products & Services: Custom Vector Construction

Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide

Authors: Laetitia Coassolo; Niels B. Danneskiold-Sams e; Quennie Nguyen; Amanda Wiggenhorn; Meng Zhao; David Cheng-Hao Wang; David Toomer; Jameel Lone; Yichao Wei; Aayan Patel; Irene Liparulo; Deniz Kavi; Lianna W. Wat; Saranya Chidambaranathan Reghupaty; Julie Jae Kim; Tina Asemi; Ewa Bielczyk-Maczynska; Veronica L. Li; Maria Dolores Moya-Garzon; Nicole A. J. Krentz; Andreas Stahl; Danny Hung-Chieh Chou; Liqun Luo; Katrin J. Svensson

Journal: Nature

PubMed ID: 40044869

Doi: 10.1038/s41586-025-08683-y

Mapping monoclonal anti-SARS-CoV-2 antibody repertoires against diverse coronavirus antigens

Authors: Matheus Oliveira de Souza, Bharat Madan, I-Ting Teng, Aric Huang, Lihong Liu, Ahmed S Fahad, Sheila N Lopez Acevedo, Xiaoli Pan, Mallika Sastry, Matias Gutierrez-Gonzalez, Michael T Yin, Tongqing Zhou, David D Ho, Peter D Kwong, Brandon J DeKosky

Journal: Front Immunol

PubMed ID: 36119018

Doi: 10.3389/fimmu.2022.977064

Products & Services: Protein and Antibody Isolation

Vaccine target and carrier molecule nontypeable Haemophilus influenzae protein D dimerizes like the close Escherichia coli GlpQ homolog but unlike other known homolog dimers

Authors: Seth P Jones, Kali H Cook, Melody L Holmquist, Liam J Almekinder, Annie M Delaney, Ryhl Charles, Natalie Labbe, Janai Perdue, Niaya Jackson, Michael E Pichichero, Ravinder Kaur, Lea V Michel, Michael L Gleghorn

Journal: Proteins

PubMed ID: 36065600

Doi: 10.1002/prot.26418

Products & Services: Protein and Antibody Isolation

Peptide-Based HDL as an Effective Delivery System for Lipophilic Drugs to Restrain Atherosclerosis Development

Authors: Junwei Gao, Ziyun Li, Jing Li, Ping Song, Jinsheng Yang, Wei Xiao, Ning Li, Ruodan Xu

Journal: Int J Nanomedicine

PubMed ID: 36097444

Doi: 10.2147/IJN.S374736

Products & Services: Gene Synthesis

SPTLC1 variants associated with ALS produce distinct sphingolipid signatures through impaired interaction with ORMDL proteins

Authors: Museer A Lone, Mari J Aaltonen, Aliza Zidell, Helio F Pedro, Jonas A Morales Saute, Shalett Mathew, Payam Mohassel, Carsten G Bönnemann, Eric A Shoubridge, Thorsten Hornemann

Journal: J Clin Invest

PubMed ID: 35900868

Doi: 10.1172/JCI161908

Products & Services: Protein and Antibody Isolation

Structural characterization of SARS-CoV-2 dimeric ORF9b reveals potential fold-switching trigger mechanism

Authors: Xiyue Jin, Xue Sun, Yan Chai, Yu Bai, Ying Li, Tianjiao Hao, Jianxun Qi, Hao Song, Catherine C L Wong, George F Gao

Journal: Sci China Life Sci

PubMed ID: 36184694

Doi: 10.1007/s11427-022-2168-8

Products & Services: Plasmid DNA Preparation

A recombinant subunit vaccine candidate produced in plants elicits neutralizing antibodies against SARS-CoV-2 variants in macaques

Authors: Narach Khorattanakulchai, Kanjana Srisutthisamphan, Balamurugan Shanmugaraj, Suwimon Manopwisedjaroen, Kaewta Rattanapisit, Chalisa Panapitakkul, Taratorn Kemthong, Nutchanat Suttisan, Suchinda Malaivijitnond, Arunee Thitithanyanont, Anan Jongkaewwattana, Waranyoo Phoolcharoen

Journal: Front Plant Sci

PubMed ID: 36247553

Doi: 10.3389/fpls.2022.901978

Products & Services: Protein and Antibody Isolation

Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening

Authors: Peter C DeWeirdt, Abby V McGee, Fengyi Zheng, Ifunanya Nwolah, Mudra Hegde, John G Doench

Journal: Nat Commun

PubMed ID: 36068235

Doi: 10.1038/s41467-022-33024-2

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Selection and characterization of bispecific aptamers against malachite green and leucomalachite green

Authors: Wenwei Wu, Qifeng Sun, Tiansong Li, Kexin Liu, Yan Jiang, Yi Wang, Yongjie Yang

Journal: Anal Biochem

PubMed ID: 36150472

Doi: 10.1016/j.ab.2022.114849

Products & Services: Gene Synthesis