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Loss of LGR4/GPR48 causes severe neonatal salt wasting due to disrupted WNT signaling altering adrenal zonation

Authors: Cécily Lucas, Kay-Sara Sauter, Michael Steigert, Delphine Mallet, James Wilmouth, Julie Olabe, Ingrid Plotton, Yves Morel, Daniel Aeberli, Franca Wagner, Hans Clevers, Amit V Pandey, Pierre Val, Florence Roucher-Boulez, Christa E Flück

Journal: JOURNAL OF CLINICAL INVESTIGATION

PubMed ID: 36538378

Doi: 10.1172/JCI164915

Products & Services: Protein and Antibody Isolation

Single-cell resolution reveals RalA GTPase expanding hematopoietic stem cells and facilitating of BCR-ABL1-driven leukemogenesis in a CRISPR/Cas9 gene editing mouse model

Authors: Zhao Yin, Rui Su, Lanlan Ge, Xiuyuan Wang, Juhua Yang, Guiping Huang, Chuting Li, Yanjun Liu, Keda Zhang, Lan Deng, Jia Fei

Journal: International journal of biological sciences

PubMed ID: 36923939

Doi: 10.7150/ijbs.76993

Products & Services: CRISPR KI Templates

Mechanistic Basis for a Connection between the Catalytic Step and Slow Opening Dynamics of Adenylate Kinase

Authors: Beata Dulko-Smith, Pedro Ojeda-May, Jörgen Ådén, Magnus Wolf-Watz, Kwangho Nam

Journal: J Chem Inf Model

PubMed ID: 36802243

Doi: 10.1021/acs.jcim.2c01629

Products & Services: Protein and Antibody Isolation

Therapeutic Targeting of LIF Overcomes Macrophage-mediated Immunosuppression of the Local Tumor Microenvironment

Authors: Robin M Hallett, Ester Bonfill-Teixidor, Raffaella Iurlaro, Alexandra Arias, Swetha Raman, Peter Bayliss, Olga Egorova, Almudena Neva-Alejo, Aj Robert McGray, Esther Lau, Alexandre Bosch, Melissa Beilschmidt, Dorothea Maetzel, Johan Fransson, Isabel Huber-Ruano, Judit Anido, Jean-Philippe Julien, Patricia Giblin, Joan Seoane

Journal: Clin Cancer Res

PubMed ID: 36441800

Doi: 10.1158/1078-0432.CCR-21-1888

Products & Services: Peptide Synthesis

Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease

Authors: Raaj S Mehta, Jared R Mayers, Yancong Zhang, Amrisha Bhosle, Nathaniel R Glasser, Long H Nguyen, Wenjie Ma, Sena Bae, Tobyn Branck, Kijun Song, Luke Sebastian, Julian Avila Pacheco, Hyuk-Soo Seo, Clary Clish, Sirano Dhe-Paganon, Ashwin N Ananthakrishnan, Eric A Franzosa, Emily P Balskus, Andrew T Chan, Curtis Huttenhower

Journal: Nat Med

PubMed ID: 36823301

Doi: 10.1038/s41591-023-02217-7

Products & Services: Protein and Antibody Isolation

Exocytic machineries differentially control mediator release from allergen-triggered RBL-2H3 cells

Authors: Pratikshya Adhikari, Tolulope E Ayo, John C Vines, Shuzo Sugita, Hao Xu

Journal: Inflamm Res

PubMed ID: 36725743

Doi: 10.1007/s00011-023-01698-z

Products & Services: Protein and Antibody Isolation

Transplantation of A2 type astrocytes promotes neural repair and remyelination after spinal cord injury

Authors: Jie Chang, Zhanyang Qian, Binyu Wang, Jiang Cao, Sheng Zhang, Fan Jiang, Renyi Kong, Xiao Yu, Xiaojian Cao, Lei Yang, Hongtao Chen