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Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity

Authors: Hudie Wei , Haolan Wang , Genxin Wang , Lingzhi Qu , Longying Jiang , Shuyan Dai , Xiaojuan Chen , Ye Zhang , Zhuchu Chen , Youjun Li , Ming Guo , Yongheng Chen

Journal: Nat Commun .

PubMed ID: 37463921

Doi: 10.1038/s41467-023-40087-2

Products & Services: Protein and Antibody Isolation

The ubiquitin-protein ligase MIEL1 localizes to peroxisomes to promote seedling oleosin degradation and lipid droplet mobilization

Authors: Melissa S Traver , Bonnie Bartel

Journal: Proc Natl Acad Sci U S A .

PubMed ID: 37410814

Doi: 10.1073/pnas.2304870120

Products & Services: Gene Synthesis

Unravelling the Therapeutic Potential of Antibiotics in Hypoxia in a Breast Cancer MCF-7 Cell Line Model

Authors: Almaz A Akhunzianov , Alfiya I Nesterova , Sjoerd Wanrooij , Yulia V Filina , Albert A Rizvanov , Regina R Miftakhova

Journal: Int J Mol Sci .

PubMed ID: 37511298

Doi: 10.3390/ijms241411540

Products & Services: Catalog Antibodies

A mechanical-coupling mechanism in OSCA/TMEM63 channel mechanosensitivity

Authors: Mingfeng Zhang , Yuanyue Shan , Charles D Cox , Duanqing Pei

Journal: Nat Commun .

PubMed ID: 37402734

Doi: 10.1038/s41467-023-39688-8

Products & Services: Protein and Antibody Isolation

Increase in SARS-CoV-2 Seroprevalence in UK Domestic Felids Despite Weak Immunogenicity of Post-Omicron Variants

Authors: Grace B Tyson, Sarah Jones, Chloe Montreuil-Spencer, Nicola Logan, Sam Scott, Hagar Sasvari, Michael McDonald, Leigh Marshall, Pablo R Murcia, Brian J Willett, William Weir, Margaret J Hosie

Journal: Viruses

PubMed ID: 37632004

Doi: 10.3390/v15081661

Products & Services: Protein and Antibody Isolation

Functionally diverse front-end desaturases are widespread in the phylum Annelida

Authors: Marc Ramos-Llorens, Francisco Hontoria, Juan C Navarro, David E K Ferrier, Óscar Monroig

Journal: Biochim Biophys Acta Mol Cell Biol Lipids

PubMed ID: 37517549

Doi: 10.1016/j.bbalip.2023.159377

Products & Services: Combinatorial Mutant library

PAQR9 regulates glucose homeostasis in diabetic mice and modulates insulin secretion in β cells in vitro under stress conditions

Authors: Zixuan Li, Yijun Lin, Shixuan Zhuo, Jinzhu Chen, Lingling Chen, Shuying Wang, Yan Chen

Journal: Mol Cell Endocrinol

PubMed ID: 37499998

Doi: 10.1016/j.mce.2023.112032

Products & Services: Custom DNA/RNA Oligos

Transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States

Authors: Aijing Feng, Sarah Bevins, Jeff Chandler, Thomas J DeLiberto, Ria Ghai, Kristina Lantz, Julianna Lenoch, Adam Retchless, Susan Shriner, Cynthia Y Tang, Suxiang Sue Tong, Mia Torchetti, Anna Uehara, Xiu-Feng Wan

Journal: Nat Commun

PubMed ID: 37429851

Doi: 10.1038/s41467-023-39782-x

Products & Services: Protein and Antibody Isolation

A conserved motif in the disordered linker of human MLH1 is vital for DNA mismatch repair and its function is diminished by a cancer family mutation

Authors: Karla Wolf, Jan Kosinski, Toby J Gibson, Nicole Wesch, Volker Dötsch, Maurizio Genuardi, Emanuela Lucci Cordisco, Stefan Zeuzem, Angela Brieger, Guido Plotz

Journal: Nucleic Acids Res

PubMed ID: 37224528

Doi: 10.1093/nar/gkad418

Products & Services: Peptide Synthesis

Prediction of cooperative homeodomain DNA binding sites from high-throughput-SELEX data

Authors: Brittany Cain, Jordan Webb, Zhenyu Yuan, David Cheung, Hee-Woong Lim, Rhett A Kovall, Matthew T Weirauch, Brian Gebelein

Journal: Nucleic Acids Res

PubMed ID: 37114997

Doi: 10.1093/nar/gkad318

Products & Services: Plasmid DNA Preparation