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Computational design and molecular dynamics simulations suggest the mode of substrate binding in ceramide synthases
Authors: Iris D Zelnik, Beatriz Mestre, Jonathan J Weinstein, Tamir Dingjan, Stav Izrailov, Shifra Ben-Dor, Sarel J Fleishman, Anthony H Futerman
Journal: Nat Commun
PubMed ID: 37087500
Doi: 10.1038/s41467-023-38047-x
Products & Services: Proteins, Expression, Isolation and Analysis   
A Recombinant Chimeric Cedar Virus-Based Surrogate Neutralization Assay Platform for Pathogenic Henipaviruses
Authors: Moushimi Amaya, Randy Yin, Lianying Yan, Viktoriya Borisevich, Bishwo N Adhikari, Andrew Bennett, Francisco Malagon, Regina Z Cer, Kimberly A Bishop-Lilly, Antony S Dimitrov, Robert W Cross, Thomas W Geisbert, Christopher C Broder
Journal: Viruses
PubMed ID: 37243163
Doi: 10.3390/v15051077
Products & Services: Molecular Biology Reagents   
H, N, C backbone and Cβ resonance assignments for UBQLN1 UBA and UBAA domains
Authors: Gwen R Buel, Xiang Chen, Olumide Kayode, Anthony Cruz, Kylie J Walters
Journal: Biomol NMR Assign
PubMed ID: 37022617
Doi: 10.1007/s12104-023-10127-5
Products & Services: Custom Vector Construction   
Enhanced Degradation of Mutant -Derived Toxic Dipeptide Repeat Proteins by 20S Proteasome Activation Results in Restoration of Proteostasis and Neuroprotection
Authors: Allison S Vanecek, Jelena Mojsilovic-Petrovic, Robert G Kalb, Jetze J Tepe
Journal: ACS Chem Neurosci
PubMed ID: 37015082
Doi: 10.1021/acschemneuro.2c00732
Products & Services: Recombinant Proteins   
Direct Virus Gene Detection: A CRISPR/dCas9-Mediated Surface- Enhanced Raman Scattering Strategy with Enzyme-Catalyzed Signal Amplification
Authors: Ailing Su , Yuan Liu , Xiumian Cao , Junyi Zhao , Weiqing Xu , Chongyang Liang , Ping Li , Shuping Xu
Journal: Anal Chem .
PubMed ID: 36995921
Doi: 10.1021/acs.analchem.2c05384
Products & Services: Synthetic sgRNA and crRNA Service   
Insufficient epitope-specific T cell clones are responsible for impaired cellular immunity to inactivated SARS-CoV-2 vaccine in older adults
Authors: Chanchan Xiao, Zhiyao Ren , Bei Zhang , Lipeng Mao , Guodong Zhu , Lijuan Gao , Jun Su , Jiezhou Ye , Ze Long , Yue Zhu , Pengfei Chen , Xiangmeng Su , Tong Zhou , Yanhao Huang , Xiongfei Chen , Chaojun Xie , Jun Yuan , Yutian Hu , Jingshan Zheng , Zhigang Wang , Jianrong Lou , Xiang Yang , Zhiqiang Kuang , Hongyi Zhang , Pengcheng Wang , Xiaofeng Liang , Oscar Junhong Luo , Guobing Chen
Journal: Nat Aging .
PubMed ID: 37117789
Doi: 10.1038/s43587-023-00379-0
Products & Services: Peptide Synthesis   
Diversity of the Gβγ complexes defines spatial and temporal bias of GPCR signaling
Authors: Ikuo Masuho , Nickolas K Skamangas , Brian S Muntean , Kirill A Martemyanov
Journal: Cell Syst .
PubMed ID: 33667409
Doi: 10.1016/j.cels.2021.02.001
Products & Services: Gene Synthesis   
Structural Insights into M1 Muscarinic Acetylcholine Receptor Signaling Bias between Gαq and β-Arrestin through BRET Assays and Molecular Docking
Authors: Dongxue Wang, Yunjin Yao, Shiqi Wang, Yifei Hou, Lanxue Zhao, Hao Wang, Hongzhuan Chen, Jianrong Xu
Journal: Int J Mol Sci
PubMed ID: 37108518
Doi: 10.3390/ijms24087356
Products & Services: Proteins, Expression, Isolation and Analysis   
Melittin derived peptide-drug conjugate, M-DM1, inhibits tumor progression and induces effector cell infiltration in melanoma by targeting M2 tumor-associated macrophages
Authors: Chanmi Jeong, Jeongdong Kim, Ik-Hwan Han, Soyoung Kim, Ilseob Choi, Hongsung Kim, Jin-Hyun Jeong, Hyunsu Bae
Journal: Front Immunol
PubMed ID: 37122692
Doi: 10.3389/fimmu.2023.1178776
Products & Services: Proteins, Expression, Isolation and Analysis   
A Ferritin Nanoparticle-Based Zika Virus Vaccine Candidate Induces Robust Humoral and Cellular Immune Responses and Protects Mice from Lethal Virus Challenge
Authors: Aryamav Pattnaik, Bikash R Sahoo, Lucas R Struble, Gloria E O Borgstahl, You Zhou, Rodrigo Franco, Raul G Barletta, Fernando A Osorio, Thomas M Petro, Asit K Pattnaik
Journal: Vaccines (Basel)
PubMed ID: 37112733
Doi: 10.3390/vaccines11040821
Products & Services: Gene Synthesis   

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