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Impact of SARS-CoV-2 spike stability and RBD exposure on antigenicity and immunogenicity

Authors: Lucy Rutten, Maarten Swart, Annemart Koornneef, Pascale Bouchier, Sven Blokland, Ava Sadi, Jarek Juraszek, Aneesh Vijayan, Sonja Schmit-Tillemans, Johan Verspuij, Ying Choi, Chenandly E Daal, Aditya Perkasa, Shessy Torres Morales, Sebenzile K Myeni, Marjolein Kikkert, Jeroen Tolboom, Daniëlle van Manen, Harmjan Kuipers, Hanneke Schuitemaker, Roland Zahn, Johannes P M Langedijk

Journal: Sci Rep

PubMed ID: 38459086

Doi: 10.1038/s41598-024-56293-x

Products & Services: Codon Optimization

Atrogin-1 promotes muscle homeostasis by regulating levels of endoplasmic reticulum chaperone BiP

Authors: Avnika A Ruparelia, Margo Montandon, Jo Merriner, Cheng Huang, Siew Fen Lisa Wong, Carmen Sonntag, Justin P Hardee, Gordon S Lynch, Lee B Miles, Ashley Siegel, Thomas E Hall, Ralf B Schittenhelm, Peter D Currie

Journal: JCI Insight

PubMed ID: 38530354

Doi: 10.1172/jci.insight.167578

Products & Services: Molecular Biology Reagents

Mucosal tumor vaccination delivering endogenous tumor antigens protects against pulmonary breast cancer metastases

Authors: Friederike Oltmanns, Ana Vieira Antão, Pascal Irrgang, Vera Viherlehto, Leticia Jörg, Anna Schmidt, Jannik T Wagner, Michael Rückert, Ann-Sophie Flohr, Carol Imanuel Geppert, Benjamin Frey, Wibke Bayer, Claudia Gravekamp, Matthias Tenbusch, Udo Gaipl, Dennis Lapuente

Journal: J Immunother Cancer

PubMed ID: 38458636

Doi: 10.1136/jitc-2023-008652

Products & Services: Peptide Synthesis

CAR-engineered lymphocyte persistence is governed by a FAS ligand/FAS auto-regulatory circuit

Authors: Fei Yi, Tal Cohen, Natalie Zimmerman, Friederike Dündar, Paul Zumbo, Razan Eltilib, Erica J Brophy, Hannah Arkin, Judith Feucht, Michael V Gormally, Christopher S Hackett, Korbinian N Kropp, Inaki Etxeberria, Smita S Chandran, Jae H Park, Katharine C Hsu, Michel Sadelain, Doron Betel, Christopher A Klebanoff

Journal: biorxiv

PubMed ID: 38464085

Doi: 10.1101/2024.02.26.582108

Products & Services: Gene Synthesis

YAP/TAZ-TEAD activity promotes the malignant transformation of cervical intraepithelial neoplasia through enhancing the characteristics and Warburg effect of cancer stem cells

Authors: Shu Li, Xing Li, Yong-Bin Yang, Su-Fang Wu

Journal: Apoptosis

PubMed ID: 38553612

Doi: 10.1007/s10495-023-01935-0

Products & Services: Molecular Biology Reagents

Oxygen Activation in Aromatic Ring Cleaving Salicylate Dioxygenase: Detection of Reaction Intermediates with a Nitro-substituted Substrate Analog

Authors: Qian Wang, Hanbin Li, Uran Bujupi, Janosch Gröning, Andreas Stolz, Angelo Bongiorno, Rupal Gupta

Journal: Chembiochem

PubMed ID: 38363551

Doi: 10.1002/cbic.202400023

Products & Services: Molecular Biology Reagents

HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity

Authors: Lei Chu, Li Qian, Yu Chen, Shengnan Duan, Ming Ding, Wu Sun, Wei Meng, Juanjuan Zhu, Quanyi Wang, Haiping Hao, Chen Wang, Shufang Cui

Journal: Cell Reports

PubMed ID: 38421872

Doi: 10.1016/j.celrep.2024.113870

Products & Services: Recombinant Proteins

GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer

Authors: Zu Ye, Shengfeng Xu, Yin Shi, Xueqian Cheng, Yuan Zhang, Sunetra Roy, Sarita Namjoshi, Michael A Longo, Todd M Link, Katharina Schlacher, Guang Peng, Dihua Yu, Bin Wang, John A Tainer, Zamal Ahmed

Journal: Nature Communications

PubMed ID: 38459011

Doi: 10.1038/s41467-024-46283-y.

Products & Services: Peptide Synthesis

Novel Fragment Inhibitors of PYCR1 from Docking-Guided X-ray Crystallography

Authors: Kaylen R Meeks, Juan Ji , Mykola V Protopopov , Olga O Tarkhanova , Yurii S Moroz , John J Tanner

Journal: J Chem Inf Model

PubMed ID: 38411104

Doi: 10.1021/acs.jcim.3c01879

Products & Services: Molecular Biology Reagents

A Synergistic Lipid Nanoparticle Encapsulating mRNA Shingles Vaccine Induces Potent Immune Responses and Protects Guinea Pigs from Viral Challenges

Authors: Xingdi Cheng 1 2, Sujia Liu 3, Jing Sun 4, Lin Liu 3, Xinghuan Ma 3, Jingjiao Li 1 2, Bangda Fan 3, Chen Yang 1 2, Yuanyuan Zhao 1 2, Shuai Liu 1, Yixing Wen 1 2, Wei Li 1 2, Simin Sun 1, Shiwei Mi 1 2, Haonan Huo 1 2, Lei Miao 5, Hao Pan 6, Xiaolan Cui 4, Jiaqi Lin 3, Xueguang Lu 1 2

Journal: Adv Mater

PubMed ID: 38145557

Doi: 10.1002/adma.20231088

Products & Services: Plasmid DNA Preparation