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Nanosized Shikonin Disrupts Tumor-cell Mismatch Repair and Synergizes with Manganese to Sensitize Squamous Carcinoma to Immunotherapy

Authors: Shan Yu, Jingyuan Li, Jie Zhang, Guozhong Zeng, Bin Zeng, Shuyuan Song, Zhentao Lao, Haolin Chen, Zhenfu Wen, Zeyu Yang, Xiang Li, Kan Li, Le Yang, Hong Liu, Lixin Liu, Guiqing Liao, Yongming Chen, Yujie Liang

Journal: ACS Nano

PubMed ID: 40190094

Doi: 10.1021/acsnano.4c17090.

Products & Services: Protein and Antibody Isolation

Cryo-EM structures of the small-conductance Ca2+-activated KCa2.2 channel

Authors: Young-Woo Nam, Dohyun Im, Ana Santa Cruz Garcia, Marios L Tringides, Hai Minh Nguyen, Yan Liu, Razan Orfali, Alena Ramanishka, Grigore Pintilie, Chih-Chia Su, Meng Cui, Diomedes E Logothetis, Edward W Yu, Heike Wulff, K George Chandy, Miao Zhang

Journal: Nat Commun

PubMed ID: 40246884

Doi: /10.1038/s41467-025-59061-1

Products & Services: Gene Synthesis

2A-biohydrogels accelerate diabetic wound healing by promoting M2 macrophage polarization and functionalized mitochondrial transfer to endothelial cells

Authors: Hao Wang, Min Zhou, Yifeng Ruan, Yifei Shen, Ziqi Qin, Xingbo Wu, Huiling Ling, Wushuang Ye, Yongfu Wang, Xueqi Gan

Journal: Chemical Engineering Journal

Doi: 10.1016/j.cej.2025.163130

Products & Services: Custom DNA/RNA Oligos

The Atypical Pectin Methylesterase Family Member PME31 Promotes Seedling Lipid Droplet Utilization

Authors: Sarah Hamade, Melissa S Traver , Bonnie Bartel

Journal: Plant Direct

PubMed ID: 40212536

Doi: doi.org/10.1002/pld3.70054

Products & Services: Catalog Antibodies

Peptide-conjugated alginate fiber: A skeletal muscle regenerative scaffold

Authors: Yajun Li, Yueren Wu, Tong Wu, Can Zhang, Jianwu Dai, Jianping Tang, Lin Li, Liyang Shi

Journal: Carbohydrate Polymers

PubMed ID: 39978892

Doi: 10.1016/j.carbpol.2025.123299

Products & Services: Catalog Peptides

Generation of Site-Specifically Labeled Affinity Reagents via Use of a Self-Labeling Single Domain Antibody

Authors: Stanley Fayn, Swarnali Roy, Chino C Cabalteja, Woonghee Lee, Hima Makala, Kwamena Baidoo, Divya Nambiar, Julia Sheehan-Klenk, Joon-Yong Chung, Jesse Buffington, Mitchell Ho, Freddy E Escorcia, Ross W Cheloha

Journal: Advanced Science

PubMed ID: 39965119

Doi: 10.1002/advs.202417160

Products & Services: Mammalian Expression

A rapid CAT transformation protocol and nuclear transgene expression tools for metabolic engineering in Cyanidioschyzon merolae 10D

Authors: Melany Villegas-Valencia, Martha R Stark, Mark Seger, Gordon B Wellman, Sebastian Overmans, Peter J Lammers, Stephen D Rader, Kyle J Lauersen

Journal: New biotechnology

Doi: 10.1016/j.nbt.2024.12.001

Products & Services: Gene Synthesis PCR Cloning and Subcloning

Screening the human druggable genome identifies ABHD17B as an anti-fibrotic target in hepatic stellate cells

Authors: Wenyang Li, Robert P Sparks, Cheng Sun, Yang Yang, Lorena Pantano, Rory Kirchner, Nahid Arghiani, Arden Weilheimer, Benjamin J Toles, Jennifer Y Chen, Sean P Moran, Victor Barrera, Zixiu Li, Peng Zhou, Meghan L Brassil, David Wrobel, Shannan J Ho Sui, Gary Aspnes, Michael Schuler, Jennifer Smith, Benjamin D Medoff, Chan Zhou, Carine M Boustany-Kari, Jörg F Rippmann, Daniela M Santos, Julia F Doerner, Alan C Mullen

Journal: Nature Communications

PubMed ID: 40025044

Doi: 10.1038/s41467-025-56900-z

Products & Services: Gene Synthesis

CODANIN-1 sequesters ASF1 by using a histone H3 mimic helix to regulate the histone supply

Authors: Tae-Kyeong Jeong, R Ciaran MacKenzie Frater, Jongha Yoon, Anja Groth, Ji-Joon Song

Journal: Nature Communications

PubMed ID: 40038274

Doi: 10.1038/s41467-025-56976-7

Products & Services: Protein and Antibody Isolation

A WYL domain transcription factor regulates Lactiplantibacillus plantarum intestinal colonization via perceiving c-di-GMP

Authors: Quan Guo, Guangqiang Wang, Leijie Zheng, Hui Xue, Ruimin Wang, Yajing Fang, Jiachao Zhang

Journal: Nature Communications

PubMed ID: 40038299

Doi: 10.1038/s41467-025-57581-4

Products & Services: Peptide Synthesis