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A fluorescence-based assay for measuring polyamine biosynthesis aminopropyl transferase mediated catalysis
Authors: Pallavi Singh; Jae-Yeon Choi; Weiwei Wang; Tukiet T. Lam; Philip Lechner; Christopher D. Vanderwal; Sovitj Pou; Aaron Nilsen; Choukri Ben Mamoun
Journal: The Journal of Biological Chemistry
PubMed ID: 39342998
Doi: 10.1016/j.jbc.2024.107832
Discovery of benzethonium chloride as a potent STAT3 inhibitor for the treatment of HNSCC
Authors: Yuefeng Han; Shumin Li; Deshang Chen; Mingjie Zhang; Guoying Han; QianQian Xu; Xianming Ge; Mengli Wang; Yan Pan; Sien Ma; Beibei Xu; Mengmeng Deng; Bao Zhao
Journal: Frontiers in pharmacology
PubMed ID: 40242440
Doi: 10.3389/fphar.2025.1569570
Products & Services: Protein and Antibody Isolation   
Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors
Authors: Xujie Zhang; Lin Sun; Megan E. Meuser; Waleed A. Zalloum; Shujing Xu; Tianguang Huang; Srinivasulu Cherukupalli; Xiangyi Jiang; Xiao Ding; Yucen Tao; Dongwei Kang; Erik De Clercq; Christophe Pannecouque; Alexej Dick; Simon Cocklin; Xinyong Liu; Peng Zhan
Journal: European Journal of Medicinal Chemistry
PubMed ID: 34592608
Doi: 10.1016/j.ejmech.2021.113848
Products & Services: Peptide Synthesis   
Microglial MS4A4A Protects against Epileptic Seizures in Alzheimer's Disease
Authors: Meng Jiang, Qingqing Li, Jianhui Chen, Ruochong Li, Jun Yao, Yong Hu, Haizheng Zhang, Lixin Cai, Maoguo Luo, Yu Sun, Wenwen Zeng
Journal: Advanced Science
PubMed ID: 40349168
Doi: 10.1002/advs.202417733
Products & Services: Protein and Antibody Isolation   
HR eye & MMR eye: one-day assessment of DNA repair-defective tumors eligible for targeted therapy
Authors: Shinta Saito, Shingo Kato, Usaki Arai, Atsuki En, Jun Tsunezumi, Taichi Mizushima, Kensuke Tateishi, Noritaka Adachi
Journal: Nature Communications
PubMed ID: 40355434
Doi: 10.1038/s41467-025-59462-2
Products & Services: Gene Synthesis   
A FAN1 point mutation associated with accelerated Huntington's disease progression alters its PCNA-mediated assembly on DNA
Authors: Jonas Aretz, Gayathri Jeyasankar, Anna Salerno-Kochan, Maren Thomsen, Gabriel Thieulin-Pardo, Tasir Haque, Edith Monteagudo, Dan Felsenfeld, Michael Finley, Thomas F Vogt, Julien Boudet, Brinda C Prasad
Journal: Nature Communications
PubMed ID: 40368883
Doi: 10.1038/s41467-025-59324-x
Products & Services: Gene Synthesis   
Structural basis of phosphorylation-independent nuclear import of CIRBP by TNPO3
Authors: Qishun Zhou, Theo Sagmeister, Saskia Hutten, Benjamin Bourgeois, Tea Pavkov-Keller, Dorothee Dormann, Tobias Madl
Journal: Nature Communications
PubMed ID: 40360518
Doi: 10.1038/s41467-025-59802-2
Products & Services: Custom Vector Construction   
Modular deregulation of central carbon metabolism for efficient xylose utilization in Saccharomyces
Authors: Xiaowei Li, Yanyan Wang, Xin Chen, Leon Eisentraut, Chunjun Zhan, Jens Nielsen, Yun Chen
Journal: Nature Communications
PubMed ID: 40379631
Doi: 10.1038/s41467-025-59966-x
Products & Services: Gene Synthesis   
Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca2+ dependent allosteric binding site
Authors: Leslie A Dakin, Li Xing, Justin Hall, Weidong Ding, Felix F Vajdos, Jeffrey W Pelker, Simeon Ramsey, Paul Balbo, Parag V Sahasrabudhe, Mary Ellen Banker, Won Young Choi, Stephen W Wright, Jeanne S Chang, John M Curto, Jennifer E Davoren, Susan E Drozda, Kimberly F Fennell, Kentaro Futatsugi, Steve Kortum, Katherine L Lee, Shenping Liu, Frank Lovering, Jennifer A Nicki, John I Trujillo, Fabien Vincent, Mark E Schnute
Journal: Nature Communications
PubMed ID: 40379660
Doi: 10.1038/s41467-025-59919-4
Products & Services: Gene Synthesis   
Interaction networks of SIM-binding groove mutants reveal alternate modes of SUMO binding and profound impact on SUMO conjugation
Authors: Laura A Claessens, Matty Verlaan-de Vries, Nienke Broekman, Martijn S Luijsterburg, Alfred C O Vertegaal
Journal: SCIENCE ADVANCES
PubMed ID: 40367183
Doi: 10.1126/sciadv.adp2643
Products & Services: Gene Synthesis   
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