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Multivalent S2 subunit vaccines provide broad protection against Clade 1 sarbecoviruses in female mice

Authors: Peter J. Halfmann, Raj S. Patel, Kathryn Loeffler, Atsuhiro Yasuhara, Lee-Ann Van De Velde, Jie E. Yang, Jordan Chervin, Chloe Troxell, Min Huang, Naiying Zheng, Elizabeth R. Wright, Paul G. Thomas, Patrick C. Wilson, Yoshihiro Kawaoka & Ravi S. Kane

Journal: Nature Communications

PubMed ID: 39774966

Doi: 10.1038/s41467-025-55824-y

Products & Services: Custom Vector Construction

Structural and bioinformatics analyses identify deoxydinucleotide-specific nucleases and their association with genomic islands in gram-positive bacteria

Authors: Sofia Mortensen, Stanislava Kuncová, Justin D Lormand, Tanner M Myers, Soo-Kyoung Kim, Vincent T Lee, Wade C Winkler, Holger Sondermann

Journal: Nucleic Acids Research

PubMed ID: 39778863

Doi: 10.1093/nar/gkae1235

Products & Services: Gene Synthesis

Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity

Authors: Mingjiong Zhang, Jiahua Cui, Haoyan Chen, Yifan Cheng, Qiaoyu Chen, Feng Zong, Xiao Lu, Lang Qin, Yu Han, Xingwang Kuai, Yuxing Zhang, Minjie Chu, Shuangshuang Wu & Jianqing Wu

Journal: Nature Communications

PubMed ID: 39805872

Doi: 10.1038/s41467-025-56002-w

Products & Services: Protein and Antibody Reagents

Scale-free Spatio-temporal Correlations in Conformational Fluctuations of Intrinsically Disordered Proteins

Authors: Haoyu Song, Jian Cui, Guorong Hu, Long Xiong, Yanee Wutthinitikornkit, Hai Lei, Jingyuan Li

Journal: Advanced Science

PubMed ID: 39807013

Doi: 10.1002/advs.202412989

Products & Services: Gene Synthesis

Recombinant expression systems for production of stabilised virus-like particles as next-generation polio vaccines

Authors: Lee Sherry, Mohammad W. Bahar, Claudine Porta, Helen Fox, Keith Grehan, Veronica Nasta, Helen M. E. Duyvesteyn, Luigi De Colibus, Johanna Marsian, Inga Murdoch, Daniel Ponndorf, Seong-Ryong Kim, Sachin Shah, Sarah Carlyle, Jessica J. Swanson, Sue Matthews, Clare Nicol, George P. Lomonossoff, Andrew J. Macadam, Elizabeth E. Fry, David I. Stuart, Nicola J. Stonehouse & David J. Rowlands

Journal: Nature Communications

PubMed ID: 39827284

Doi: 10.1038/s41467-025-56118-z

Products & Services: Gene Fragments

Discovering CRISPR-Cas system with self-processing pre-crRNA capability by foundation models

Authors: Wenhui Li, Xianyue Jiang, Wuke Wang, Liya Hou, Runze Cai, Yongqian Li, Qiuxi Gu, Qinchang Chen, Peixiang Ma, Jin Tang, Menghao Guo, Guohui Chuai, Xingxu Huang, Jun Zhang, Qi Liu

Journal: Nature Communications

PubMed ID: 39789054

Products & Services: Synthetic Guide RNA

Probing SARS-CoV-2 membrane binding peptide via single-molecule AFM-based force spectroscopy

Authors: Qingrong Zhang, Raissa S. L. Rosa, Ankita Ray, Kimberley Durlet, Gol Mohammad Dorrazehi, Rafael C. Bernardi & David Alsteens

Journal: Nature Communications

PubMed ID: 39747000

Doi: 10.1038/s41467-024-55358-9

Products & Services: Peptide Synthesis

MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis

Authors: Sarah V. Faull, Marta Barbon, Audrey Mossler, Zuanning Yuan, Lin Bai, L. Maximilian Reuter, Alberto Riera, Christian Winkler, Indiana Magdalou, Matthew Peach, Huilin Li & Christian Speck

Journal: Nature Communications

PubMed ID: 39747125

Doi: 10.1038/s41467-024-55479-1

Products & Services: Mutagenesis Services

Dietary amino acids promote glucagon-like hormone release to generate global calcium waves in adipose tissues in Drosophila

Authors: Muhammad Ahmad, Shang Wu, Shengyao Luo, Wenjia Shi, Xuan Guo, Yuansheng Cao, Norbert Perrimon & Li He

Journal: Nature Communications

PubMed ID: 39747032

Doi: 10.1038/s41467-024-55371-y

Products & Services: Peptide Synthesis

Regulation of N-degron recognin-mediated autophagy by the SARS-CoV-2 PLpro ubiquitin deconjugase

Authors: Carlos Ayala-Torres , Jiangnan Liu , Nico P Dantuma , Maria G Masucci

Journal: Autophagy

PubMed ID: 39723606

Doi: 10.1080/15548627.2024.2442849

Products & Services: Gene Synthesis