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The protein phosphatase 2A-B56α complex regulates N-Myc degradation in neuroblastoma

Authors: Brian D Tran, Irene Peris, Ethan Wurman, Averie Huang, Gabrielle Hodges Onishi, Jiang Hu, Rita A Avelar, Erika A Newman, Analisa DiFeo, Caitlin M O'Connor, Goutham Narla

Journal: Molecular Therapy

PubMed ID: 41707997

Doi: 10.1016/j.jbc.2026.111298

Characterization of gRNA-dependent and gRNA-independent off-target binding sites of PspCas13b and RfxCas13d in mammalian cells

Authors: Huanhuan Feng, Zhixue Li, Hongdao Zhang, Yuli Zheng, Beiying Xu, Yao Zhang, Lin Zou, Ligang Wu

Journal: Nucleic Acids Research

PubMed ID: 41728952

Doi: 10.1093/nar/gkag112

Identifying microbial protease allergens through protein language model-guided homology

Authors: Kumar Thurimella, Elena Wu, Chenhao Li, Daniel B Graham, Róisín M Owens, Damian R Plichta, Caroline L Sokol, Ramnik J Xavier, Sergio Bacallado

Journal: Molecular Therapy

PubMed ID: 41722567

Doi: 10.1016/j.cels.2025.101510

GbWAKL20 Phosphorylates GbNFYB8 to Modulate Verticillium Wilt Resistance in Cotton

Authors: Guilin Wang, Qingxin Si, Zhiguo Chen, Zhe Yu, Zhan Guo, Lu Wang, Weixi Li, Wangzhen Guo

Journal: Advanced Science

PubMed ID: 41521460

Doi: 10.1002/advs.202515724

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Structural basis for the subtype-selectivity of KCa2.2 channel activators

Authors: Young-Woo Nam, Alena Ramanishka, Yang Xu, Rose Marie Haynes Yasuda, Joshua A Nasburg, Dohyun Im, Meng Cui, K George Chandy, Heike Wulff, Miao Zhang

Journal: Nature Communications

PubMed ID: 41507196

Doi: 10.1038/s41467-025-67232-3

Products & Services: Mutagenesis Services

Intranasal replicon vaccine establishes mucosal immunity and protects against H5N1 and H7N9 influenza

Authors: Matthew R Ykema, Michael A Davis, Darshan N Kasal, Madeleine F Jennewein, Ethan Lo, Jasneet Singh, Samuel Beaver, Noah Cross, Eduard Melief, Sierra Reed, Christopher Press, Devin S Brandt, Wynton D McClary, Raodoh Mohamath, Pauline Fusco, Julie Bakken, Corey Casper, Airn Tolnay Hartwig, Alana Gerhardt, Richard A Bowen, Emily A Voigt

Journal: Nature Communications

PubMed ID: 41530119

Doi: 10.1038/s41467-025-64829-6

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Development of a split-toxin CRISPR screening platform to systematically identify regulators of human myoblast fusion

Authors: Haifeng Zhang, Renjie Shang, Zheng Zhang, Min Zhou, Anne Bigot, Yanqing Cai, Yanran Zhao, Yushu Wang, Aaryahi Deshmukh, Elena Kudryashova, Dmitri S Kudryashov, Cuiyu He, Vincent Mouly, Pengpeng Bi

Journal: Nature Communications

PubMed ID: 41540035

Doi: 10.1038/s41467-025-67583-x

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A disulfide redox switch mechanism regulates glycoside hydrolase function

Authors: Marcele Pandeló Martins, Gustavo Henrique Martins, Felipe Jun Fuzita, João Paulo Menezes Spadeto, Renan Yuji Miyamoto, Felippe Mariano Colombari, Fabiane Stoffel, Luciano Graciani Dolce, Camila Ramos Dos Santos, Rodrigo Silva Araujo Streit, Antônio Carlos Borges, Rafael Henrique Galinari, Yoshihisa Yoshimi, Paul Dupree, Gabriela Felix Persinoti, Mariana Abrahão Bueno Morais, Mario Tyago Murakami

Journal: Nature Communications

PubMed ID: 41491304

Doi: 10.1038/s41467-025-67225-2

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Engineered outer membrane vesicles enhance solid tumour CAR-T cell therapy

Authors: Xianjun Li, Xuehan Li, Jiaqi Shi, Yingjing Li, Hanyu Zhang, Tianjun Chen, Hui Pang, Shuyuan Zhang, Shengnan Luo, Fengyi Liu, Shuang Li, Chujie Ding, Linlin Sun, Fan Xing, Tongsen Zheng

Journal: Nature biomedical engineering

PubMed ID: 41501251

Doi: 10.1038/s41551-025-01575-6

Products & Services: Recombinant Proteins

Targeted stress granule regulation by engineering a non-catalytic O-GlcNAc transferase

Authors: Na Wang, Fanjia Hou, Sihui Ma, Silan Liu, Haimei Wei, Weicheng Fang, Ke Zhang, Yun Ge

Journal: Nature Communications

PubMed ID: 41501012

Doi: 10.1038/s41467-025-66689-6

Products & Services: Protein Electrophoresis and Western