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Rapamycin nanoparticles increase the therapeutic window of engineered interleukin-2 and drive expansion of antigen-specific regulatory T cells for protection against autoimmune disease
Authors: Takashi Kei Kishimoto, Max Fournier, Alicia Michaud, Gina Rizzo, Christopher Roy, Teresa Capela, Natasha Nukolova, Ning Li, Liam Doyle, Fen-Ni Fu, Derek VanDyke, Peter G Traber, Jamie B Spangler, Sheldon S Leung, Petr O Ilyinskii
Journal: J Autoimmun
PubMed ID: 37844543
Doi: 10.1016/j.jaut.2023.103125
Products & Services: Protein and Antibody Isolation   
Aptabinding of tumor necrosis factor-α (TNFα) inhibits its proinflammatory effects and alleviates islet inflammation
Authors: Roaa Mahmoud, Jagan Kalivarathan, Abdul J Castillo, Sasha Wang, Brian Fuglestad, Mazhar A Kanak, Soma Dhakal
Journal: Biotechnol J
PubMed ID: 37772688
Doi: 10.1002/biot.202300374
Products & Services: Molecular Biology Reagents   
GhL1L1 regulates the contents of unsaturated fatty acids by activating the expression of GhFAD2 genes in cotton
Authors: Dandan Yue, Xuyang Hao, Bei Han, Jiao Xu, Weinan Sun, Xiaoping Guo, Xianlong Zhang, Xiyan Yang
Journal: Gene
PubMed ID: 37839764
Doi: 10.1016/j.gene.2023.147899
Products & Services: PCR Cloning and Subcloning   
A newly identified ferritin L-subunit variant results in increased proteasomal subunit degradation, impaired complex assembly, and severe hypoferritinemia
Authors: Dayana Shagidov, Noga Guttmann-Raviv, Séverine Cunat, Liora Frech, Muriel Giansily-Blaizot, Niraj Ghatpande, Gili Abelya, Gabriel A Frank, Patricia Aguilar Martinez, Esther G Meyron-Holtz
Journal: Am J Hematol
PubMed ID: 37867341
Doi: 10.1002/ajh.27124
Products & Services: Protein and Antibody Isolation   
Characterization of a thermostable Cas12a ortholog
Authors: Jing Wu, Pan Gao, Yajing Shi, Caixiang Zhang, Xiaohan Tong, Huidi Fan, Xi Zhou, Ying Zhang, Hao Yin
Journal: Cell Insight
PubMed ID: 38047138
Doi: 10.1016/j.cellin.2023.100126
Products & Services: Molecular Biology Reagents   
A circRNA therapy based on Rnf103 to inhibit Vibrio anguillarum infection
Authors: Weiwei Zheng, Xing Lv, Yaqi Tao, Yanqiu Cui, Xiangxiang Zhu, Tongtong Zhu, Tianjun Xu
Journal: Cell Rep
PubMed ID: 37874674
Doi: 10.1016/j.celrep.2023.113314
Products & Services: DNA Sequencing   
Genistein alleviates chronic heat stress-induced lipid metabolism disorder and mitochondrial energetic dysfunction by activating the GPR30-AMPK-PGC-1α signaling pathways in the livers of broiler chickens
Authors: Longlong Li, Ze Lu, Yulei Wang, Ying Yang, Huihui Wang, Haitian Ma
Journal: Poult Sci
PubMed ID: 37984004
Doi: 10.1016/j.psj.2023.103251
Products & Services: Protein and Antibody Isolation   
Condensation of the N-terminal domain of human topoisomerase 1 is driven by electrostatic interactions and tuned by its charge distribution
Authors: Greta Bianchi, Marco Mangiagalli, Diletta Ami, Junaid Ahmed, Silvia Lombardi, Sonia Longhi, Antonino Natalello, Peter Tompa, Stefania Brocca
Journal: Int J Biol Macromol
PubMed ID: 38287572
Doi: 10.1016/j.ijbiomac.2023.127754
Products & Services: Protein and Antibody Isolation   
Cell-Permeable Stimuli-Responsive Ubiquitin Probe for Time- Resolved Monitoring of Substrate Ubiquitination in Live Cells
Authors: Lu-Jun Liang, Yu Wang, Xiao Hua, Rujing Yuan, Qiong Xia, Rongtian Wang, Chuntong Li, Guo-Chao Chu, Lei Liu, and Yi-Ming Li
Journal: JACS Au
Doi: 10.1021/jacsau.3c00421
Products & Services: Gene Synthesis   
A thermostable type I-B CRISPR-Cas system for orthogonal and multiplexed genetic engineering
Authors: Zhiheng Yang , Zilong Li , Bixiao Li , Ruihong Bu , Gao-Yi Tan , Zhengduo Wang , Hao Yan , Zhenguo Xin , Guojian Zhang , Ming Li , Hua Xiang, Lixin Zhang , Weishan Wang
Journal: Nat Commun .
PubMed ID: 37794017
Doi: 10.1038/s41467-023-41973-5
Products & Services: Custom DNA/RNA Oligos   CRISPR Libraries   
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