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A recurrent pathogenic BRCA2 truncating variant reveals a role for BRCA2-PCAF complex in modulating NF-κB-driven transcription

Authors: Anna Minello, Jesus Gomez-Escudero, Sreerama Chaitanya Sridhara, Charlotte Martin, Elodie Girard, Juan C Cañas, Yasin Memari, Maria Rose Bustos, Antonio Galarreta, Virginie Boucherit, Evgeny Imyanitov, Sigridur Klara Bodvarsdottir, Sylvain Baulande, Anne Vincent-Salomon, Nicolas Servant, Matthias Altmeyer, Stefan Sigurdsson, Dominique Stoppa-Lyonnet, Serena Nik-Zainal, Aura Carreira

Journal: Nature Communications

PubMed ID: 41372141

Doi: 10.1038/s41467-025-67209-2

Products & Services: Polyclonal Antibody Services

HYPK promotes N-terminal protein acetylation through rapid ribosome exchange of NatA

Authors: Alfred M Lentzsch, Ziyi Fan, Inayat U Irshad, Edward P O'Brien, Ajeet K Sharma, Rachel Green, Shu-Ou Shan

Journal: Molecular Cell

PubMed ID: 41380682

Doi: 10.1016/j.molcel.2025.11.017

Products & Services: Peptide Synthesis

Membralin Assembles a MAN1B1–VCP Complex to Target Foreign Glycoproteins from the Endoplasmic Reticulum to Lysosomes for Degradation

Authors: Jing Zhang, Xiaoran Lu, Sunan Li, Tao Wang, Iqbal Ahmad, Yong-Hui Zheng

Journal: Advanced Science

PubMed ID: 41324484

Doi: 10.1002/advs.202519256

Products & Services: Custom Vector Construction

U-Shaped Response of Flowering Time to Low and High Nitrogen via a Transcription Feedback Loop in Rice

Authors: Shunan Zhang, Guanzhong Shou, Xianping Li, Xuemin Song, Xuesong Li, Junjie Guo, Jiaqiang Lu, Yi Jin, Hongye Qu, Ming Yan, Wona Ding, Ying Liu, Guohua Xu

Journal: Advanced Science

PubMed ID: 41354635

Doi: 10.1002/advs.202508498

Tuning CAR-T cells by targeting cancer-associated glycan in pancreatic cancer

Authors: Sangwoo Park, Cassidy E Ho, Eli P Darnell, Alexandra N Wolff, Hana Takei, Filippo Birocchi, Amanda A Bouffard, Diego Salas-Benito, Giulia Escobar, Mark B Leick, Adele Mucci, Trisha R Berger, Marcela V Maus

Journal: Nature Communications

PubMed ID: 41372740

Doi: 10.1038/s41467-025-66102-2

Gut Microbe-Driven Resistance Mechanisms in Propylea Japonica: Insights from Horizontal Gene Transfer and Oxidative Phosphorylation

Authors: Ningbo HuangFu, Xiangzhen Zhu, Zhijuan Tang, Li Wang, Kaixin Zhang, Dongyang Li, Jichao Ji, Jinjie Cui, Zhaojiang Guo, Junyu Luo, Xueke Gao

Journal: Advanced Science

PubMed ID: 41386783

Doi: 10.1002/advs.202520326

Products & Services: Protein Electrophoresis and Western

Collision-induced ribosome degradation driven by ribosome competition and translational perturbations

Authors: Sihan Li, Okuto Shounai, Misaki Kato, Ken Ikeuchi, Toshifumi Inada

Journal: Nature Communications

PubMed ID: 41387539

Doi: 10.1038/s41467-025-66026-x

Products & Services: Peptide Synthesis

Engineering HLA-G-targeted extracellular vesicles nanoplatform for enhanced cancer therapy through precise cancer drug delivery

Authors: Ming-You Shie, Shi-Wei Huang, Yeh Chen, Mei-Chih Chen, Chih-Ming Pan, Cheng-Yu Chen, Yen-Hong Lin, Min-Hua Yu, Kai-Wen Kan, Shao-Chih Chiu, Hui-Chun Ho, Yi-Wen Chen, Der-Yang Cho

Journal: Nature Communications

PubMed ID: 41390497

Doi: 10.1038/s41467-025-66451-y

Cynarin as a potent anti‑osteolytic agent: Targeting MAPK and Nrf2‑Keap1 pathways for osteoclast inhibition and bone protection

Authors: Rui Chao, Yexin Wang, Zhan Liu, Tianhao Wan, Yi Mao, Xinru Xie, Lei Sun, Weifeng Xu, Xuzhuo Chen, Shanyong Zhang

Journal: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

PubMed ID: PMC12488209

Doi: 10.3892/ijmm.2025.5647

Products & Services: Protein and Antibody Isolation

Excessive vigorous exercise impairs cognitive function through a muscle-derived mitochondrial pretender

Authors: Yan Huang, Biao Hu, Ya Liu, Ling-Qi Xie, Yu Dai, Yu-Ze An, Xin-Yi Peng, Ya-Lun Cheng, Yi-Fan Guo, Wei-Hong Kuang, Yao Xiao, Xin Chen, Yong-Jun Zheng, Gen-Qing Xie, Jian-Ping Wang, Hui Peng, Xiang-Hang Luo

Journal: Cell metabolism

PubMed ID: 41344322

Doi: doi.org/10.1016/j.cmet.2025.11.002

Products & Services: Nucleic Acid Purification