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EXPERT expands prime editing efficiency and range of large fragment edits

Authors: Youcai Xiong , Yinyu Su , Ruigao He , Xiaosong Han , Sheng Li , Minghuan Liu , Xiaoning Xi , Zijia Liu , Heng Wang , Shengsong Xie , Xuewen Xu , Kui Li , Jifeng Zhang , Jie Xu , Xinyun Li , Shuhong Zhao , Jinxue Ruan

Journal: Nat Commun

PubMed ID: 39939583

Doi: 10.1038/s41467-025-56734-9

Products & Services: Gene Synthesis

Self-assembly GSH response based Buforin IIb-Olaparib nanocombination synergistically promotes DNA damage for prostate cancer immunotherapy

Authors: Maosong Hu , Yuyu Zhu , Xinyi Tang , Jing Xu , Hanbin Ma , Zhihan Chen , Duo Chen , Wenyuan Wu , Xialin Chen , Rongrong He , Jing Zhou , Jinao Duan , Weiguo Chen , Hongyue Ma

Journal: Chemical Engineering Journal

Doi: 10.1016/j.cej.2025.160862

Products & Services: Peptide Synthesis

Deciphering molecular specificity in MCL-1/BAK interaction and its implications for designing potent MCL-1 inhibitors

Authors: Hudie Wei, Haolan Wang, Shuang Xiang, Jiaqi Wang, Lingzhi Qu, Xiaojuan Chen, Ming Guo, Xiaoyun Lu, Yongheng Chen

Journal: Cell Death Differ

PubMed ID: 39901037

Doi: 10.1038/s41418-025-01454-2

Products & Services: Peptide Synthesis

Expanding Cas12a Activity Control with an RNA G-Quadruplex at the 5′ end of CRISPR RNA

Authors: Wenjuan Huang, Jiaqi Wang, Cheng Wang, Yuanfang Liu, Wentao Li, Qiaozhen Chen, Junqiu Zhai, Zhenyang Xiang, Chaoxing Liu

Journal: Advanced Science

PubMed ID: 39721016

Doi: 10.1002/advs.202411305

Products & Services: Catalog Gene Editing

Activation of the bacterial defenseassociated sirtuin system

Authors: Kaixiang Zhu, Kun Shang, Linyue Wang, Xia Yu, Lei Hua, Weihe Zhang, Bo Qin, Jia Wang, Xiaopan Gao, Hongtao Zhu, Sheng Cui

Journal: Communications Biology

PubMed ID: 39994439

Doi: doi.org/10.1038/s42003-025-07743-3

Products & Services: Gene Synthesis

Structures of HCoV-OC43 HR1 Domain in Complex with Cognate HR2 or Analogue EK1 Peptide

Authors: Xiuxiu He, Huanzhen Liu, Guang Yang, Lei Yan

Journal: Viruses-Basel

PubMed ID: 40143271

Doi: 10.3390/v17030343

Products & Services: Peptide Synthesis

Bioengineered protein nanocarrier facilitating siRNA escape from lysosomes for targeted RNAi therapy in glioblastoma

Authors: Yiliang Jin, Baoli Zhang, Jianru Li, Zhenxi Guo, Chen Zhang, Xuehui Chen, Long Ma, Zhuoran Wang, Haiyin Yang, Yong Li, Yuhua Weng, Yuanyu Huang, Xiyun Yan, Kelong Fan

Journal: SCIENCE ADVANCES

PubMed ID: 39970222

Doi: 10.1126/sciadv.adr9266

Products & Services: Gene Synthesis

Design of CoQ10 crops based on evolutionary history

Authors: Jing-Jing Xu, Yuan Lei, Xiao-Fan Zhang, Jian-Xu Li, Qiupeng Lin, Xiang-Dong Wu, Yu-Guo Jiang, Wenyi Zhang, Runtong Qian, Shu-Yi Xiong, Kuo Tan, Yu Jia, Qiang Zhou, Yan Jiang, Hang Fan, Yan-Bo Huang, Ling-Jian Wang, Ji-Yun Liu, Yu Kong, Qing Zhao, Lei Yang, Jinxing Liu, Yong-Hong Hu, Shuai Zhan, Caixia Gao, Xiao-Ya Chen

Journal: Cell

PubMed ID: 39952246

Doi: 10.1016/j.cell.2025.01.023

Products & Services: Custom Vector Construction

The TaCLE24b peptide signaling cascade modulates lateral root development and drought tolerance in wheat

Authors: Wen Yang, Man Feng, Kuohai Yu, Jie Cao, Guangxian Cui, Yumei Zhang, Huiru Peng, Yingyin Yao, Zhaorong Hu, Zhongfu Ni, Feng Qin, Fuminori Takahashi, Qixin Sun, Mingming Xin

Journal: Nature Communications

PubMed ID: 40000659

Doi: 10.1038/s41467-025-57291-x

Products & Services: Peptide Synthesis

RH3 enhances antiviral defense by facilitating small RNA loading into Argonaute 2 at endoplasmic reticulum–chloroplast membrane contact sites

Authors: Juan Huang, Juan Du, Yan Liu, Lu Lu, Yanzhuo Xu, Jianfei Shi, Qing Liu, Qi Li, Yang Liu, Yaqiu Chen, Meng Du, Yiming Zhao, Liangxiao Huo, Weiran Wang, Chenxi Ding, Liya Wei, Jianguo Wu, Yao-Wu Yuan, Jinfeng Chen, Ruixi Li, Feng Cui, Xiaoming Zhang

Journal: Nature Communications

PubMed ID: 40000658

Doi: 10.1038/s41467-025-57296-6

Products & Services: Codon Optimization