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Unexpected enzymatic function of an ancient nucleic acid-binding fold

Authors: Rylan R Watkins, Stella Bockelman, Anna Vradi, Kaylee Grabarkewitz, Alexa Pyun, Josephine Stark, Vicki H Wysocki, Juan D Alfonzo, Karin Musier-Forsyth

Journal: Nucleic Acids Research

PubMed ID: 40274265

Doi: 10.1093/nar/gkaf328

Products & Services: Gene Synthesis

DNA-guided transcription factor interactions extend human gene regulatory code

Authors: Zhiyuan Xie, Ilya Sokolov, Maria Osmala, Xue Yue, Grace Bower, J. Patrick Pett, Yinan Chen, Kai Wang, Ayse Derya Cavga, Alexander Popov, Sarah A. Teichmann, Ekaterina Morgunova, Evgeny Z. Kvon, Yimeng Yin & Jussi Taipale

Journal: Nature

PubMed ID: 40205063

Doi: 10.1038/s41586-025-08844-z

Products & Services: Gene Synthesis

Inhibition of CHI3L1 attenuates excessive autophagy in intestinal epithelial cells to reduce the severity of necrotizing enterocolitis

Authors: Yihui Li, Wenqiang Sun, Xinyun Jin, Huiwen Li, Xue Liu, Jingtao Bian, Xueping Zhu

Journal: Cell Death Discov

PubMed ID: 40188090

Doi: 10.1038/s41420-025-02443-7.

Products & Services: Protein and Antibody Isolation

Nanosized Shikonin Disrupts Tumor-cell Mismatch Repair and Synergizes with Manganese to Sensitize Squamous Carcinoma to Immunotherapy

Authors: Shan Yu, Jingyuan Li, Jie Zhang, Guozhong Zeng, Bin Zeng, Shuyuan Song, Zhentao Lao, Haolin Chen, Zhenfu Wen, Zeyu Yang, Xiang Li, Kan Li, Le Yang, Hong Liu, Lixin Liu, Guiqing Liao, Yongming Chen, Yujie Liang

Journal: ACS Nano

PubMed ID: 40190094

Doi: 10.1021/acsnano.4c17090.

Products & Services: Protein and Antibody Isolation

Cryo-EM structures of the small-conductance Ca2+-activated KCa2.2 channel

Authors: Young-Woo Nam, Dohyun Im, Ana Santa Cruz Garcia, Marios L Tringides, Hai Minh Nguyen, Yan Liu, Razan Orfali, Alena Ramanishka, Grigore Pintilie, Chih-Chia Su, Meng Cui, Diomedes E Logothetis, Edward W Yu, Heike Wulff, K George Chandy, Miao Zhang

Journal: Nat Commun

PubMed ID: 40246884

Doi: /10.1038/s41467-025-59061-1

Products & Services: Gene Synthesis

2A-biohydrogels accelerate diabetic wound healing by promoting M2 macrophage polarization and functionalized mitochondrial transfer to endothelial cells

Authors: Hao Wang, Min Zhou, Yifeng Ruan, Yifei Shen, Ziqi Qin, Xingbo Wu, Huiling Ling, Wushuang Ye, Yongfu Wang, Xueqi Gan

Journal: Chemical Engineering Journal

Doi: 10.1016/j.cej.2025.163130

Products & Services: Custom DNA/RNA Oligos

The Atypical Pectin Methylesterase Family Member PME31 Promotes Seedling Lipid Droplet Utilization

Authors: Sarah Hamade, Melissa S Traver , Bonnie Bartel

Journal: Plant Direct

PubMed ID: 40212536

Doi: doi.org/10.1002/pld3.70054

Products & Services: Catalog Antibodies

Peptide-conjugated alginate fiber: A skeletal muscle regenerative scaffold

Authors: Yajun Li, Yueren Wu, Tong Wu, Can Zhang, Jianwu Dai, Jianping Tang, Lin Li, Liyang Shi

Journal: Carbohydrate Polymers

PubMed ID: 39978892

Doi: 10.1016/j.carbpol.2025.123299

Products & Services: Catalog Peptides

Sequence and taxonomic feature evaluation facilitated the discovery of alcohol oxidases

Authors: Yilei Han, Xuwei Ding, Junjian Tan, Yajuan Sun, Yunjiang Duan, Zheng Liu, Gaowei Zheng, Diannan Lu

Journal: Synthetic and Systems Biotechnology

PubMed ID: 40386440

Doi: doi.org/10.1016/j.synbio.2025.04.014

Products & Services: Molecular Biology Reagents

A chemical radar allows bacteria to detect and kill predators

Authors: Shuaibing Zhang, Kevin Schlabach, Victor Hugo Pérez Carrillo, Anan Ibrahim, Shahran Nayem, Anna Komor, Ruchira Mukherji, Somak Chowdhury, Lisa Reimer, Felix Trottmann, A Corina Vlot, Christian Hertweck, Ute A Hellmich, Pierre Stallforth

Journal: Cell

PubMed ID: 40179883

Doi: 10.1016/j.cell.2025.02.033