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The PYRIN domain is required for TLR4-mediated inflammation by PYHIN family members

Authors: Andrea Iannucci, Davide Lacarbonara, Valeria Caneparo, Federica Castiglioni, Andrea Butticè, Stefano Raviola, Chiara Porta, Riccardo Miggiano, Ivan Zanoni, Marisa Gariglio, Marco De Andrea

Journal: iScience

PubMed ID: 40454096

Doi: 10.1016/j.isci.2025.112413

Products & Services: Mutagenesis Services

Synergistic impact of macrolide resistance and H3N2 infection on M. pneumoniae outbreak in children

Authors: Jiali Chen, Yingdan Wang, Juan Cheng, Yunping Ma, Xin Zhang, Xuezhou Bai, Palizhati Rehati, Huashun Cui, Fan Wu, Qiuhui Pan, Jinghe Huang

Journal: Microbiology Spectrum

PubMed ID: 39998323

Doi: 10.1128/spectrum.01844-24

Products & Services: Gene Synthesis

Structure and inhibition mechanisms of Mycobacterium tuberculosis essential transporter efflux protein A

Authors: Nitesh Kumar Khandelwal, Meghna Gupta, James E Gomez, Sulyman Barkho, Ziqiang Guan, Ashley Y Eng, Tomohiko Kawate, Sree Ganesh Balasubramani, Andrej Sali, Deborah T Hung, Robert M Stroud

Journal: Nature Communications

PubMed ID: 40169593

Doi: 10.1038/s41467-025-58133-6

Products & Services: Mutagenesis Services

Ara-C suppresses H3 K27–altered spinal cord diffuse midline glioma growth and enhances immune checkpoint blockade sensitivity

Authors: Bo Pang, Yilin Wu, SongYuan An, Yuzhou Chang, Hao Yan, Han Lin, Zheng Zhao, Fan Wu, Qing Chang, Wenqing Jia, Tao Jiang, Yongzhi Wang, Ruichao Chai

Journal: SCIENCE ADVANCES

PubMed ID: 40238864

Doi: 10.1126/sciadv.adu3956

Products & Services: Protein Electrophoresis and Western

Multimeric transcription factor BCL11A utilizes two zinc-finger tandem arrays to bind clustered short sequence motifs

Authors: John R. Horton, Meigen Yu, Jujun Zhou, Melody Tran, Rithvi R. Anakal, Yue Lu, Robert M. Blumenthal, Xiaotian Zhang, Yun Huang, Xing Zhang & Xiaodong Cheng

Journal: Nature Communications

PubMed ID: 40246927

Doi: 10.1038/s41467-025-58998-7

Products & Services: Gene Synthesis

Engineering aptamer-directed phosphatase recruiting chimeras: a strategy for modulating receptor function and overcoming drug resistance

Authors: Zhilan Zhou, Yichang Liu, Ya Wang, Hang Jiang, Tingting Chen, Yingdi Zhu, Ting Fu, Juan Li

Journal: Nature Communications

PubMed ID: 40280908

Doi: 10.1038/s41467-025-59098-2

Products & Services: Protein Electrophoresis and Western

Mechanism of DNA replication fork breakage and PARP1 hyperactivation during replication catastrophe

Authors: Pedro Ortega, Elodie Bournique, Junyi Li, Ambrocio Sanchez, Gisselle Santiago, Brooke R Harris, Josefine Striepen, John Maciejowski, Abby M Green, Rémi Buisson

Journal: SCIENCE ADVANCES

PubMed ID: 40238882

Doi: 10.1126/sciadv.adu0437

Products & Services: Gene Synthesis

Structural basis of human Mediator recruitment by the phosphorylated transcription factor Elk-1

Authors: Vincent Villeret

Journal: Nature Communications

PubMed ID: 40263353

Doi: 10.1038/s41467-025-59014-8

Products & Services: Gene Synthesis

Covalent adduct Grob fragmentation underlies LSD1 demethylase-specific inhibitor mechanism of action and resistance

Authors: Amanda L. Waterbury, Jonatan Caroli, Olivia Zhang, Paloma R. Tuttle, Chao Liu, Jiaming Li, Ji Sung Park, Samuel M. Hoenig, Marco Barone, Airi Furui, Andrea Mattevi & Brian B. Liau

Journal: Nature Communications

PubMed ID: 40175327

Doi: 10.1038/s41467-025-57477-3

Products & Services: Peptide Synthesis

Mechanistic insights into the structure-based design of a CspZ-targeting Lyme disease vaccine

Authors: Kalvis Brangulis, Jill Malfetano, Ashley L. Marcinkiewicz, Alan Wang, Yi-Lin Chen, Jungsoon Lee, Zhuyun Liu, Xiuli Yang, Ulrich Strych, Dagnija Tupina, Inara Akopjana, Maria-Elena Bottazzi, Utpal Pal, Ching-Lin Hsieh, Wen-Hsiang Chen & Yi-Pin Lin

Journal: Nature Communications

PubMed ID: 40189575

Doi: 10.1038/s41467-025-58182-x

Products & Services: Gene Synthesis