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Metabolic and immunomodulatory control of type 2 diabetes via generating cellular itaconate reservoirs by inflammatory-targeting gene-therapy nanovesicles

Authors: An Lao, Weiqi Li, Yiting Sun, Yuting Cao, Yu Zhuang, Jianyong Wu, Dejian Li, Kaili Lin, Jing Mao, Jiaqiang Liu

Journal: Trends in biotechnology

PubMed ID: 40925799

Doi: 10.1016/j.tibtech.2025.07.025

Products & Services: Protein and Antibody Isolation

A reproducible hybrid membrane for in situ analysis of cell secretions with a wide size range

Authors: Zixuan Chen, Yafeng Wu, Zhaoyan Tian, Zhaohan Wang, Weiwei Liu, Songqin Liu

Journal: Chinese Chemical Letters

Doi: 10.1016/j.cclet.2025.110917

Products & Services: Recombinant Proteins

De novo design of hypercompact transcript degraders by engineering substrate-specific toxins and Cas6-CBS system

Authors: Pin-Ru Chen, Pei-Pei Qin, Ya-Nan Wang, Peng-Fu Liu, Xin-Yue Zhang, Tao Qian, Bang-Ce Ye, Bin-Cheng Yin

Journal: Nat Commun

PubMed ID: 41006213

Doi: 10.1038/s41467-025-63166-y

Products & Services: Gene Synthesis

SLC25A39 overexpression exacerbates lung adenocarcinoma progression and is negatively regulated by AFG3L2

Authors: Wenxuan Hu, Jian Yang, Zhike Chen, Yongsen Li, Gaomeng Luo, Kang Hu, Zihao Lu, Xin Lv, Yonghao Cao, Haoyang Yuan, Cong Cao, Jun Zhao, Chun Xu

Journal: NPJ precision oncology

PubMed ID: 40993178

Doi: 10.1038/s41698-025-01081-7

Products & Services: Protein and Antibody Isolation

High-throughput crystallographic fragment screening of Zika virus NS3 Helicase

Authors: Andre Schutzer Godoy; Charline Giroud; Nathalya C. M. R. Mesquita; Gabriela Dias Noske; Victor Oliveira Gawriljuk; Ryan M Lithgo; Blake H Balcomb; Jasmin Cara Aschenbrenner; Charles W.E. Tomlinson; Max Winokan; Jenke Scheen; Hugo MacDermott-Opeskin; Peter George Marples; Anu V. Chandran; Xiaomin Ni; Warren Thompson; Michael Fairhead; Daren Fearon; Lizb Koekemoer; Mary-Ann Elvina Xavier; Martin Walsh; Glaucius Oliva; Frank von Delft

Journal: biorxiv

PubMed ID: 38746241

Doi: 10.1101/2024.04.27.591279

Structural insights into cationic amino acid transport and viral receptor engagement by CAT1

Authors: Lingyun Xia; Bingqian Lin; Rongfeng Zou; Yanyan Wu; Jiaying Xu; Yan Pan; Yuan Yuan; Shuo Li; Yang Yang; Xuemin Chen

Journal: Nature Communications

PubMed ID: 41408058

Doi: 10.1038/s41467-025-67704-6

Products & Services: Protein and Antibody Isolation

Structural insights into cationic amino acid transport and viral receptor engagement by CAT1

Authors: Lingyun Xia; Bingqian Lin; Rongfeng Zou; Yanyan Wu; Jiaying Xu; Yan Pan; Yuan Yuan; Shuo Li; Yang Yang; Xuemin Chen

Journal: Nature Communications

PubMed ID: 41408058

Doi: 10.1038/s41467-025-67704-6

Products & Services: Protein and Antibody Isolation

A rationally designed 18-amino acid peptide with potential as GLP-1 receptor agonist

Authors: Aditi Singh; Sucharita Shadangi; Soumendra Rana

Journal: Frontiers in pharmacology

PubMed ID: 42244872

Doi: 10.3389/fphar.2026.1789257

Structure-based lead optimization of enterovirus D68 2A protease inhibitors

Authors: Bin Tan; Chang Liu; Kan Li; Prakash Jadhav; George Lambrinidis; Lan Zhu; Linda Olson; Haozhou Tan; Yu Wen; Antonios Kolocouris; Wei Liu; Jun Wang

Journal: Journal of Medicinal Chemistry

PubMed ID: 37857371

Doi: 10.1021/acs.jmedchem.3c00995

A tick saliva serpin, Ixs S17 inhibits host innate immune system proteases and enhances host colonization by Lyme disease agent

Authors: Thu-Thuy Nguyen; Tae Heung Kim; Emily Bencosme-Cuevas; Jacquie Berry; Alex Samuel Kiarie Gaithuma; Moiz Ashraf Ansari; Tae Kwon Kim; Lucas Tirloni; Zeljko Radulovic; James J. Moresco; John R. Yates; Albert Mulenga

Journal: PLOS Pathogens

PubMed ID: 38394332

Doi: 10.1371/journal.ppat.1012032

Products & Services: Monoclonal Antibody Services