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Antifibrotic drug finerenone restores fertility in premature ovarian insufficiency

Authors: Zexiong Lin, Yuan Li, Yu Zhao, Dongteng Liu, Shuzi Deng, Jingkai Gu, Yanyan Li, Xudong Zhao, Peishan Wu, Yuan Xiao, Jiaping Su, Yiting Sun, Yihui Zhang, Yin Lau Lee, Yorino Sato, Haitao Zeng, Haonan Lu, Juanhui Zhang, Jennifer K Y Ko, Jing Zhao, Kazuhiro Kawamura, Ernest H Y Ng, Shanfang Jiang, Yu Li, Xi Xia, Karen K L Chan, William S B Yeung, Tianren R Wang, Kui Liu

Journal: Science

PubMed ID: 41643022

Doi: 10.1126/science.adz4075

Products & Services: Custom DNA/RNA Oligos

Expression of IMD-CBM peptide induces the autophagic degradation of CAV1 (caveolin 1) to inhibit LDL transcytosis and retard diabetic atherosclerosis

Authors: Li Wang, Xiong Jia, Xiangli Bai, Ying Zhao, Wenzhuo Cheng, Meng Shu, Yan Shu, Liyin Zhang, Ruonan Wang, Si Jin

Journal: Autophagy

PubMed ID: 41686177

Doi: 10.1080/15548627.2026.2631946

CD3ɛ Nanobody-Engineered Extracellular Vesicles Driving In Vivo Generation of BiTE-Secreting CAR-Ts for Solid Tumor Therapy With Memory Response and Minimal Immunogenicity

Authors: Shi-Wei Huang, Yu-Chuan Lin, Chih-Ming Pan, Yeh Chen, Ming-You Shie, Cheng-Yu Chen, Kai-Wen Kan, Yi-Wen Chen, Ming-Chao Liu, Chung-Chun Wu, Yu-Ting Chiang, Huai-Ping Ho, Chen-Yu Lin, Pei-Ying Lin, Yu-Han Huang, Steffany Rusli, Wan-Yu Mao, Pei-Wen Huang, Sin-Ting Wang, Wan-Chen Tsai, Ya-Hsu Chiu, Ting-Hsun Lin, Wan-Ling Chiang, Che-Kai Chang, Zi-Lun Lai, Mei-Chih Chen, Shao-Chih Chiu, Der-Yang Cho

Journal: Advanced Science

PubMed ID: 41632088

Doi: 10.1002/advs.202519440

Rapid elicitation of neutralizing Asn332-glycan-independent antibodies to the V3-glycan epitope of HIV-1 Env in nonhuman primates

Authors: Ignacio Relano-Rodriguez, Jianqiu Du, Zi Jie Lin, Margaret Kerwin, Marta Tarquis-Medina, Eduardo Urbano, Jiayan Cui, Meagan Watkins, Christy L Lavine, Peng Zhao, Rumi Habib, Colby Agostino, Sukanya Ghosh, Joyce Park, Caroline Boroughs, Agnes A Walsh, Mariane B Melo, Niharika Shukla, George M Shaw, Beatrice H Hahn, Darrell J Irvine, Lance Wells, David B Weiner, Michael S Seaman, Daniel W Kulp, Ronald S Veazey, Jesper Pallesen, Amelia Escolano

Journal: nature immunology

PubMed ID: 41634485

Doi: 10.1038/s41590-025-02408-z

Safe and Highly Efficient Lipid-Pro-Dexamethasone Nanoparticles for mRNA Delivery and Base Editing

Authors: Yan Zong, Haiping Zhong, Yuqing Wang, Yi Lin, Linxi Zhao, Xiaoyu Wang, Jianan Cai, Haoyang Lin, Yixi Xiao, Tuo Wei, Shutao Guo, Qiang Cheng

Journal: Journal of the American Chemical Society

PubMed ID: 41733506

Doi: 10.1021/jacs.6c01708

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Identifying microbial protease allergens through protein language model-guided homology

Authors: Kumar Thurimella, Elena Wu, Chenhao Li, Daniel B Graham, Róisín M Owens, Damian R Plichta, Caroline L Sokol, Ramnik J Xavier, Sergio Bacallado

Journal: Molecular Therapy

PubMed ID: 41722567

Doi: 10.1016/j.cels.2025.101510

Messenger RNA delivery to islet β cells using conjugated lipid nanoparticles

Authors: Jacob R Enriquez, Zhengjie Zhou, Jennifer B Nelson, Fei Huang, Kayla T Figatner, Advaita Chakraborty, Sarida Pratuangtham, Brian Xi, Sarah C May, Matthew V Tirrell, Sarah A Tersey, Yun Fang, Raghavendra G Mirmira

Journal: Molecular Therapy

PubMed ID: 41722565

Doi: 10.1016/j.xcrm.2026.102634

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KRASG12V/HLA-A*02:01–targeted chimeric antigen receptor T cells exhibit potent preclinical activity against solid tumors

Authors: Huimin Shao, Fei Xu, Jiangyue Xu, Lingjie Zhou, Yao Wu, Lianjun He, Xueyi Qian, Weijie He, Nanlin Jiao, Yabin Xia, Jun Zhao, Lili Sheng, Guoliang Mao, Tao Ma, Wei Wang, Shaoxiang Luo, Li Fu, Zhenyu Xu

Journal: SCIENCE ADVANCES

PubMed ID: 41719389

Doi: 10.1126/sciadv.aea2511

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Functional characterization of secreted Schistosoma mansoni serpin SmSPI reveals Factor XIIa inhibition as evidenced by biochemical, and human plasma assays and supported by AI-assisted structural modelling

Authors: Lukáš Konečný, Kristýna Peterková, Ingrid Hrachovinová, Alex Loukas, Tomáš Macháček, Jan Dvořák, Lucie Jedličková

Journal: Molecular Therapy

PubMed ID: 41724421

Doi: 10.1016/j.ijpara.2026.104808

NFS1 Regulates IDH2 to Attenuate Abdominal Aortic Aneurysms via Interacting With SP2

Authors: Luzheng Zhang, Yu Zhang, Dezhong Wen, Suxiang Guo, Xiaohui Qi, Heng Wang, Yujin Sun, Guangdong Yang, Yuehong Wang, Song Xue

Journal: Advanced Science

PubMed ID: 41637534

Doi: 10.1002/advs.202505240

Products & Services: Protein Electrophoresis and Western