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Anti-PD-L2 immunotherapy is efficacious against melanoma in aged hosts through IL-17 and IFNγ signalling
Authors: Carlos O Ontiveros, Myrna G Garcia, Clare E Murray, Yilun Deng, Haiyan Bai, Christopher Tanner, Bernice Leung, Xin Li, Alvaro Padron, Ryan M Reyes, Aravind Kancharla, Kah Teong Soh, Shanmugarajan Krishnan, Dhan Chand, Akshaya Balasubramanian, Courtney Hegner, Claudia V Jakubzick, Harshita B Gupta, Mary Jo Turk, Mark Sundrud, Jose R Conejo-Garcia, Tyler J Curiel
Journal: Nature Communications
PubMed ID: 41261166
Doi: 10.1038/s41467-025-65025-2.
Products & Services: CRISPR Libraries   
Preclinical assessment of two FcγRI-specific antibodies that competitively inhibit immune complex-FcγRI binding to suppress autoimmune responses
Authors: Tosca Holtrop, Arianne M Brandsma, Louris J Feitsma, Steffen Krohn, Petra Moerer, Frederique van den Haak, Anouk Versnel, Leonie Voss, Elsemieke M Passchier, Maaike Nederend, J H Marco Jansen, Anouk G van Mourik, Rolf T Urbanus, Diane van der Woude, Roger E G Schutgens, Rene E M Toes, Bert J C Janssen, Anja Lux, Kevin Budding, Matthias Peipp, Jeanette H W Leusen
Journal: Nature Communications
PubMed ID: 41258113
Doi: 10.1038/s41467-025-65133-z.
Products & Services: Catalog Antibodies   
Structural insight into bicarbonate-mediated carboxylation by human vitamin K-dependent carboxylase
Authors: Ke Wu, Zheng Wang, Deqiang Yao, Shaobai Li, Xiaozhu Wang, Yuanyuan Zhang, Mi Cao, Yafeng Shen, Shunpeng Xing, Jian Wu, Ming Lei, Pengfei Lan
Journal: Nature Communications
PubMed ID: 41290650
Doi: 10.1038/s41467-025-65488-3.
Products & Services: Protein and Antibody Isolation   
Structural basis of regulated N-glycosylation at the secretory translocon
Authors: Melvin Yamsek, Mengxiao Ma, Roshan Jha, Yu Wan, Qianru Li, Frank Zhong, Katherine DeLong, Zhe Ji, Rajat Rohatgi, Robert J Keenan
Journal: Nature
PubMed ID: 41261126
Doi: 10.1038/s41586-025-09756-8.
Products & Services: Catalog Antibodies   
ER protein CLCC1 promotes nuclear envelope fusion in herpesviral and host processes
Authors: Bing Dai, Adrian W Sperl, Lucas Polack, Isabel Mejia, Haley Dame, Tien Huynh, Chloe Deveney, Nathalie Lavoie, Chanyoung Lee, John G Doench, Matthew D Daugherty, Ekaterina E Heldwein
Journal: Nature Communications
PubMed ID: 41271665
Doi: 10.1038/s41467-025-65115-1.
Latent-TGF-β has a domain swapped architecture
Authors: Mingliang Jin, Robert I Seed, Tiffany Shing, Li Wang, Junrui Li, Yifan Cheng, Stephen L Nishimura
Journal: Nature Communications
PubMed ID: 41290649
Doi: 10.1038/s41467-025-65465-w.
Products & Services: Catalog Antibodies   
Development of a cross-protective common cold coronavirus vaccine
Authors: Tanushree Dangi, Shiyi Li, Pablo Penaloza-MacMaster
Journal: Journal of virology
PubMed ID: 41123344
Doi: 10.1128/jvi.01526-25
Products & Services: Codon Optimization   
Crystal structures of Ryanodine Receptor reveal dantrolene and azumolene interactions guiding inhibitor development
Authors: Hadiatullah Hadiatullah, Lianyun Lin, Zhiyan Wang, Rajamanikandan Sundarraj, Qing Wang, Xinru Lai, Nagomi Kurebayashi, Takuya Kobayashi, Toshiko Yamazawa, Yu Seby Chen, Wenlan Wang, Hongxia Zhao, Yiqing Yin, Takashi Murayama, Filip Van Petegem, Zhiguang Yuchi
Journal: Nature Communications
PubMed ID: 41253812
Doi: 10.1038/s41467-025-65096-1.
Products & Services: Protein and Antibody Isolation   
Rational design of potent small-molecule SMARCA2/A4 degraders acting via the recruitment of FBXO22
Authors: Elisia Villemure, Tom Januario, Mingshuo Zeng, Hanna G Budayeva, Benjamin T Walters, Aaron Lictao, Ke Sherry Li, Xiaofen Ye, Caroline L Gilchrist, Bridget Hoag, Nicholas F Endres, Peter L Hsu, John Chan, Tommy K Cheung, Michael R Costa, Jean-Philippe Fortin, Noriko Ishisoko, Brett M Babin, Joyce Liu, Alexandra Frommlet, Joachim Rudolph, Robert L Yauch
Journal: Nature Communications
PubMed ID: 41184243
Doi: 10.1038/s41467-025-64669-4.
PCR-generated DNA templates enable efficient, rapid, and cost-effective mRNA synthesis
Authors: Naveen Kumar, Nicholas C Hazell, Jiani Bei, Tina Nguyen, Haitao Hu
Journal: Methods
PubMed ID: 40825451
Doi: 10.1016/j.ymeth.2025.08.007
Products & Services: PCR Cloning and Subcloning   
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