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OMP16-targeting monoclonal antibodies H4 and E6 reveal essential linear epitopes for Brucella immunoprotection

Authors: Yunyi Zhai, Kaihui Sun, Ye Yuan, Xiaofang Liu, Gaowa Wudong, Yuanhao Yang, Shuan Qu, Yaxin Li, Dong Zhou, Wei Liu, Yaping Jin, Aihua Wang

Journal: International Journal of Biological Macromolecules

PubMed ID: 41448303

Doi: 10.1016/j.ijbiomac.2025.149881

Products & Services: Bacterial Expression Mutagenesis Services Peptide Synthesis

Study on the phosphorylation of NAD+-specific isocitrate dehydrogenase in the pathogenic bacteria Stenotrophomonas maltophilia and Xanthomonas sacchari

Authors: Qian Tian, Yongmei Zhang, Chunxu Pan, Linxiao Wang, Na Qin, Zhen Jiang, Chenxi Li, Zhengyu Cao, Guoping Zhu, Peng Wang

Journal: Journal of enzyme inhibition and medicinal chemistry

PubMed ID: 41395810

Doi: 10.1080/14756366.2025.2593798

Products & Services: Gene Synthesis Codon Optimization

Geminin inhibits DNA replication licensing by sterically blocking CDT1-MCM2 interactions

Authors: Joshua Tomkins, Lucy V Edwardes, Sarah V Faull, Matthew Peach, Peter J Gillespie, Vera Leber, Anna Schmidt, Halil Bounoua, Nicholas Sim, Rosa Camarillo, J Julian Blow, Alexis R Barr, Anna Barnard, Christian Speck

Journal: Nature Communications

PubMed ID: 41365879

Doi: 10.1038/s41467-025-67073-0

Induced Proprioceptor and Low-Threshold Mechanoreceptor Neurons Derived from Human Pluripotent Stem Cells Exhibit Distinct Functional Mechanosensory Properties

Authors: Amy J Hulme, Rocio K Finol-Urdaneta, Jeffrey R McArthur, Nicholas R Marzano, Simon Maksour, Amarinder Thind, Yang Guo, Dominic Kaul, Marnie Maddock, Oliver Friedrich, Boris Martinac, David J Adams, Mirella Dottori

Journal: Advanced Science

PubMed ID: 41364594

Doi: 10.1002/advs.202512413

Products & Services: Lentivirus Packaging

Nuclear speckle proteins form intrinsic and MALAT1-dependent microphases

Authors: Min Kyung Shinn, Dylan T Tomares, Vicky Liu, Avnika Pant, Yuanxin Qiu, Andreas Vitalis, You Jin Song, Yuna Ayala, Kiersten M Ruff, Gregory W Strout, Matthew D Lew, Kannanganattu V Prasanth, Rohit V Pappu

Journal: Cell

PubMed ID: 41421357

Doi: 10.1016/j.cell.2025.11.026

Synthesis of Bispecific Conjugates by ADP-Ribosyl Cyclases

Authors: Sunny H Kim, Arshad J Ansari, Lei Zhang, Guoyun Kao, Thuc Oanh Hoang, Zeyu Zhang, Srinivasarao Singireddi, Benjamin B Katz, Yong Zhang

Journal: Advanced Science

PubMed ID: 41422434

Doi: 10.1002/advs.202518329

Products & Services: Protein and Antibody Isolation

A dsRNA Viral Transcriptional Regulator Evades Innate Immunity by Hijacking Host CoTranscription Factor DHX9

Authors: Xueyang Pang, Shiyu Liu, Yixiao Zhu, Meleana M Hinchman, Nan Qiao, Xuejun Li, Weiqian Dai, Yingying Tong, Man Xing, Jiling Ren, John S L Parker, Yingying Guo, Dongming Zhou

Journal: Advanced Science

PubMed ID: 41431149

Doi: 10.1002/advs.202512262

Products & Services: Catalog Peptides

A highly active Burkholderia polyketoacyl-CoA thiolase for production of triacetic acid lactone

Authors: Zilong Wang, Seokjung Cheong, Jose Henrique Pereira, Weixi Hu, Yifan Guo, Andy DeGiovanni, Guangxu Lan, Jinho Kim, Robert W Haushalter, Taek Soon Lee, Paul D Adams, Jay D Keasling

Journal: Nature Communications

PubMed ID: 41365852

Doi: 10.1038/s41467-025-65946-y

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration

Authors: Maria G Herrera, Lena Kühn, Lisa Jungbluth, Verian Bader, Laura J Krause, David Kartte, Elias Adriaenssens, Sascha Martens, Jörg Tatzelt, Carsten Sachse, Konstanze F Winklhofer

Journal: Advanced Science

PubMed ID: 41405403

Doi: 10.1002/advs.202509927

Personalized CRISPR knock-in cytokine gene therapy to remodel the tumor microenvironment and enhance CAR T cell therapy in solid tumors

Authors: Michael Launspach, Julia Macos, Shoaib Afzal, Janik Hohmann, Marc L Appis, Maximilian Pilgram, Stefanie Beez, Emily Ohlendorf, Casper F T van der Ven, Chahrazad Lachiheb, Karin Töws, Lena Andersch, Marvin Jens, Felix Zirngibl, Jonas Kath, Maria Stecklum, Elias Rodriguez-Fos, Kathleen Anders, Dimitrios L Wagner, Anton G Henssen, Ralf Kühn, Angelika Eggert, Annette Künkele

Journal: Nature Communications

PubMed ID: 41366257

Doi: 10.1038/s41467-025-67328-w