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页码: 122/5362 每页显示数量

Design and structural basis of selective 1,4-dihydropyridine inhibitors of the calcium-activated potassium channel KCa3.1

Authors: Seow Theng Ong, Young-Woo Nam, Joshua A Nasburg, Alena Ramanishka, Xuan Rui Ng, Zhong Zhuang, Stephanie Shee Min Goay, Hai M Nguyen, Latika Singh, Vikrant Singh, Alicia Rivera, M Elaine Eyster, Yang Xu, Seth L Alper, Heike Wulff, Miao Zhang, K George Chandy

Journal: Proc Natl Acad Sci U S A

PubMed ID: 40294255

Doi: 10.1073/pnas.2425494122

Products & Services: Molecular Biology Tools

TrkC protects against osteoarthritis progression by maintaining articular cartilage homeostasis

Authors: Yongyun Chang, Keyu Kong, Hua Qiao, Minghao Jin, Xinru Wu, Wenxuan Fan, Jingwei Zhang, Yansong Qi, Yongsheng Xu, An Qin, Zanjing Zhai, Huiwu Li

Journal: International journal of biological sciences

PubMed ID: 40520017

Doi: 10.7150/ijbs.108832

Products & Services: Protein and Antibody Isolation

DNA hypermethylation of PLTP mediated by DNMT3B aggravates vascular dysfunction in diabetic retinopathy via the AKT/GSK3β signaling pathway

Authors: Chunyang Cai, Chufeng Gu, Chunren Meng, Yujie Wang, Qingquan Wei, Shuai He, Dongwei Lai, Xingyun Wang, Tengfei Wang, Qinghua Qiu

Journal: Clinical epigenetics

PubMed ID: 40380281

Doi: 10.1186/s13148-025-01874-4

Products & Services: Protein and Antibody Isolation

Influence of expression and purification protocols on G biochemical activity: kinetics of plant and mammalian G protein cycles

Authors: Timothy E. Gookin; David Chakravorty; Sarah M. Assmann

Journal: Frontiers in molecular biosciences

PubMed ID: 40260404

Doi: 10.3389/fmolb.2025.1513660

Products & Services: Gene Synthesis

Immunoinformatic strategy for developing multi-epitope subunit vaccine against Helicobacter pylori

Authors: Md. Nahian; Md. Rasel Khan; Fabiha Rahman; Hossain Mohammed Reza; Imren Bayil; Tanjum Ahmed Nodee; Tabassum Basher; Mostafizur Rahaman Sany; Rabeya Najnin Munmun; S. M. Ariful Habib; Lincon Mazumder; Mrityunjoy Acharjee; Abu Tayab Moin; Abu Tayab Moin; Abu Tayab Moin

Journal: PLoS ONE

PubMed ID: 39919064

Doi: 10.1371/journal.pone.0318750

De Novo Multi Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Authors: Xiaojuan Li; Haifan Gong; Yue Wang; Yinuo Zhao; Lixiang Li; Peijing Bao; Qingzhou Kong; Jialu Fu; Boyao Wan; Yumeng Zhang; Jinghui Zhang; Jiekun Ni; Zhongxue Han; Xueping Nan; Kunping Ju; Longfei Sun; Yuerui Ma; Huijun Chang; Mengqi Zheng; Yanbo Yu; Xiaoyun Yang; Xiuli Zuo; Haina Wang; Yanqing Li

Journal: Advanced Science

PubMed ID: 41801219

Doi: 10.1002/advs.202515835

Products & Services: Peptide Synthesis

SIRT2-mediated deacetylation of LCK governs the magnitude of T cell receptor signaling

Authors: Imene Hamaidi; Pingyan Cheng; Soo Young Jun; Alak Manna; Min-Hsuan Wang; Anh Nguyen; Ismail Can; Min G. Zhang; Odesha O. Taylor; Luis Uriel Lopez Bailon; Bin Fang; Bradford Perez; Ben C. Creelan; Andriy Marusyk; Dongjun Shin; Tae Hyun Hwang; Anders E. Berglund; Virginia S. Shapiro; Haitao M. Ji; Jos R. Conejo-Garcia; Sungjune Kim

Journal: nature immunology

PubMed ID: 41611868

Doi: 10.1038/s41590-025-02377-3

Products & Services: Custom Vector Construction

Discovery of SARS-CoV-2 Papain-like Protease Inhibitors through a Combination of High-Throughput Screening and a FlipGFP-Based Reporter Assay

Authors: Chunlong Ma; Michael Dominic Sacco; Zilei Xia; George Lambrinidis; Julia Alma Townsend; Yanmei Hu; Xiangzhi Meng; Tommy Szeto; Mandy Ba; Xiujun Zhang; Maura Gongora; Fushun Zhang; Michael Thomas Marty; Yan Xiang; Antonios Kolocouris; Yu Chen; Jun Wang

Journal: ACS central science

PubMed ID: 34341772

Doi: 10.1021/acscentsci.1c00519

Stabilization mechanism accommodating genome length variation in evolutionarily related viral capsids

Authors: Jennifer M. Podgorski, Joshua Podgorski, Lawrence Abad, Deborah Jacobs-Sera, Krista G. Freeman, Colin Brown, Graham F. Hatfull, Antoni Luque & Simon J. White

Journal: Nature Communications

PubMed ID: 40175362

Doi: 10.1038/s41467-025-58298-0

Products & Services: Gene Synthesis

Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment

Authors: Zhuoyao Chen, Gamma Chi, Timea Balo, Xiangrong Chen, Beatriz Ralsi Montes, Steven C. Clifford, Vincenzo D’Angiolella, Timea Szabo, Arpad Kiss, Tibor Novak, András Herner, András Kotschy & Alex N. Bullock

Journal: Nature Communications

PubMed ID: 40175372

Doi: 10.1038/s41467-025-58350-z

Products & Services: Gene Synthesis