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Coordinated early immune response in the lungs is required for effective control of SARS-CoV-2 replication

Authors: Klara Lenart, Hendrik Feuerstein, Mariana Prado Marmorato, Laura Perez Vidakovics, Gerald McInerney, Mimi Guebre-Xabier, Jessica F Trost, Bengt Eriksson, Gale Smith, Nita Patel, Karin Loré

Journal: Nature Communications

PubMed ID: 40562777

Doi: 10.1038/s41467-025-60885-0

Products & Services: Gene Synthesis

Accurate de novo design of high-affinity protein-binding macrocycles using deep learning

Authors: Stephen A. Rettie; David Juergens; Victor Adebomi; Yensi Flores Bueso; Qinqin Zhao; Alexandria N. Leveille; Andi Liu; Asim K. Bera; Joana A. Wilms; Alina ffing; Alex Kang; Evans Brackenbrough; Mila Lamb; Stacey R. Gerben; Analisa Murray; Paul M. Levine; Maika Schneider; Vibha Vasireddy; Sergey Ovchinnikov; Oliver H. Weiergr ber; Dieter Willbold; Joshua A. Kritzer; Joseph D. Mougous; David Baker; Frank DiMaio; Gaurav Bhardwaj

Journal: Nature Chemical Biology

PubMed ID: 40542165

Doi: 10.1038/s41589-025-01929-w

Self-assembled epitope-based nanoparticles targeting the SARS-CoV-2 spike protein enhanced the immune response and induced potential broad neutralizing activity

Authors: Yue Liu; Chenxi Li; Zirui Wu; Yu Zhao; Tieyan Yin; Xiaopan Liu; Jiaru Hui; Qingyu Wang; Yi Pan; Yaming Shan; Xinglong Qu

Journal: Frontiers in cellular and infection microbiology

PubMed ID: 40270771

Doi: 10.3389/fcimb.2025.1560330

Itraconazole promotes melanoma cells apoptosis via inhibiting hedgehog signaling pathway-mediated autophagy

Authors: Shunqiao Jin; Xiaojiao Liu; Lingqin Cai; Jiayu Yan; Ling Li; Hongjun Dong; Yuxue Gao; Xicong Zhu; Cong Zhang; Xuezhu Xu

Journal: Frontiers in pharmacology

PubMed ID: 39917616

Doi: 10.3389/fphar.2025.1545243

Products & Services: Recombinant Proteins

Itraconazole promotes melanoma cells apoptosis via inhibiting hedgehog signaling pathway-mediated autophagy

Authors: Shunqiao Jin; Xiaojiao Liu; Lingqin Cai; Jiayu Yan; Ling Li; Hongjun Dong; Yuxue Gao; Xicong Zhu; Cong Zhang; Xuezhu Xu

Journal: Frontiers in pharmacology

PubMed ID: 39917616

Doi: 10.3389/fphar.2025.1545243

Products & Services: Recombinant Proteins

Itraconazole promotes melanoma cells apoptosis via inhibiting hedgehog signaling pathway-mediated autophagy

Authors: Shunqiao Jin; Xiaojiao Liu; Lingqin Cai; Jiayu Yan; Ling Li; Hongjun Dong; Yuxue Gao; Xicong Zhu; Cong Zhang; Xuezhu Xu

Journal: Frontiers in pharmacology

PubMed ID: 39917616

Doi: 10.3389/fphar.2025.1545243

Products & Services: Recombinant Proteins

Synergistic effects of retinol and retinyl palmitate in alleviating UVB-induced DNA damage and promoting the homologous recombination repair in keratinocytes

Authors: Jiangming Zhong; Ling Liang; Nan Zhao; Jing Wang; Peng Shu

Journal: Frontiers in pharmacology

PubMed ID: 40343007

Doi: 10.3389/fphar.2025.1562244

Products & Services: Protein Electrophoresis and Western

A Chemically Induced CRISPR/dCas13 FCPF Platform for Precise and Programmable RNA Regulation

Authors: Sebastian Hasselbeck; Jianhui Wang; Zhaodai Bai; Tobias H fner; Gerhard Hummer; Phillip Grote; Xinlai Cheng

Journal: Journal of Medicinal Chemistry

PubMed ID: 41122778

Doi: 10.1021/acs.jmedchem.5c01609

A yeast-based system to study SARS-CoV-2 M pro structure and to identify nirmatrelvir resistant mutations

Authors: Jin Ou; Eric M. Lewandowski; Yanmei Hu; Austin A. Lipinski; Ryan T. Morgan; Lian M.C. Jacobs; Xiujun Zhang; Melissa J. Bikowitz; Paul Langlais; Haozhou Tan; Jun Wang; Yu Chen; John S. Choy

Journal: research square

PubMed ID: 36052369

Doi: 10.21203/rs.3.rs-1942964/v1

Products & Services: Catalog Antibodies

A rationally designed injury kidney targeting peptide library and its application in rescuing acute kidney injury

Authors: Yushuo Xiao, Zhijian Tong, Huidie Xu, Zhouyan Jia, Chen Wang, Yang Cao, Liangliang Song, Siyu Hao, Jing Yang, Yihao Zhou, Yunhao Xie, Peng Wu, Tong He, Yancai Wu, Robert B Petersen, Anlin Peng, Chun Zhang, Hong Chen, Ling Zheng, Kun Huang

Journal: SCIENCE ADVANCES

PubMed ID: 40315322

Doi: 10.1126/sciadv.adt3943

Products & Services: Peptide Synthesis