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Next generation sequencing panel based on single molecule molecular inversion probes for detecting genetic variants in children with hypopituitarism

Authors: Pérez Millán MI, Vishnopolska SA, Daly AZ, Bustamante JP, Seilicovich A, Bergadá I, Braslavsky D, Keselman AC, Lemons RM, Mortensen AH, Marti MA, Camper SA, Kitzman JO

Journal: Molecular genetics & genomic medicine

PubMed ID: 29739035

Doi: 10.1002/mgg3.395

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A Saturation Mutagenesis Approach to Understanding PTEN Lipid Phosphatase Activity and Genotype-Phenotype Relationships

Authors: Taylor L Mighell, Sara Evans-Dutson, Brian J O'Roak

Journal: Am J Hum Genet

PubMed ID: 29706350

Doi: 10.1016/j.ajhg.2018.03.018

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Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma

Authors: Zeid R, Lawlor MA, Poon E, Reyes JM, Fulciniti M, Lopez MA, Scott TG, Nabet B, Erb MA, Winter GE, Jacobson Z, Polaski DR, Karlin KL, Hirsch RA, Munshi NP, Westbrook TF, Chesler L, Lin CY, Bradner JE

Journal: Nature Genetics

PubMed ID: 29379199

Doi: 10.1038/s41588-018-0044-9

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Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands

Authors: Gechijian LN, Buckley DL, Lawlor MA, Reyes JM, Paulk J, Ott CJ, Winter GE, Erb MA, Scott TG, Xu M, Seo HS, Dhe-Paganon S, Kwiatkowski NP, Perry JA, Qi J, Gray NS, Bradner JE

Journal: Nature Chemical Biology

PubMed ID: 29507391

Doi: 10.1038/s41589-018-0010-y

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Highly selective retrieval of accurate DNA utilizing a pool of in situ-replicated DNA from multiple next-generation sequencing platforms

Authors: Lim H, Cho N, Ahn J, Park S, Jang H, Kim H, Han H, Lee JH, Bang D

Journal: Nucleic Acids Research

PubMed ID: 29361040

Doi: 10.1093/nar/gky016

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Arrayed CRISPR screen with image-based assay reliably uncovers host genes required for coxsackievirus infection

Authors: Heon Seok Kim, Kyungjin Lee, Seong-Jun Kim, Sungchan Cho, Hye Jin Shin, Chonsaeng Kim, Jin-Soo Kim

Journal: Genome Res

PubMed ID: 29712754

Doi: 10.1101/gr.230250.117

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SARNAclust: Semi-automatic detection of RNA protein binding motifs from immunoprecipitation data

Authors: Dotu I, Adamson SI, Coleman B, Fournier C, Ricart-Altimiras E, Eyras E, Chuang JH

Journal: PLoS computational biology

PubMed ID: 29596423

Doi: 10.1371/journal.pcbi.1006078

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Deep learning improves prediction of CRISPR-Cpf1 guide RNA activity

Authors: Kim HK, Min S, Song M, Jung S, Choi JW, Kim Y, Lee S, Yoon S, Kim HH

Journal: Nature Biotechnology

PubMed ID: 29431740

Doi: 10.1038/nbt.4061

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Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs

Authors: Minton DR, Nam M, McLaughlin DJ, Shin J, Bayraktar EC, Alvarez SW, Sviderskiy VO, Papagiannakopoulos T, Sabatini DM, Birsoy K, Possemato R

Journal: Molecular Cell

PubMed ID: 29452640

Doi: 10.1016/j.molcel.2018.01.024

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Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes

Authors: Neggers JE, Kwanten B, Dierckx T, Noguchi H, Voet A, Bral L, Minner K, Massant B, Kint N, Delforge M, Vercruysse T, Baloglu E, Senapedis W, Jacquemyn M, Daelemans D

Journal: Nature Communications

PubMed ID: 29402884

Doi: 10.1038/s41467-017-02349-8

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