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Optimized gene engineering of murine CAR-T cells reveals the beneficial effects of IL-15 coexpression

Authors: Evripidis Lanitis, Giorgia Rota, Paris Kosti, Catherine Ronet, Aodrenn Spill, Bili Seijo, Pedro Romero, Denarda Dangaj, George Coukos, Melita Irving

Journal: J Exp Med

PubMed ID: 33156338

Doi: 10.1084/jem.20192203

Products & Services: Molecular Biology Reagents

Robust correlations across six SARS-CoV-2 serology assays detecting distinct antibody features

Authors: Louise C Rowntree, Brendon Y Chua, Suellen Nicholson, Marios Koutsakos, Luca Hensen, Celia Douros, Kevin Selva, Francesca L Mordant, Chinn Yi Wong, Jennifer R Habel, Wuji Zhang, Xiaoxiao Jia, Lily Allen, Denise L Doolan, David C Jackson, Adam K Wheatley, Stephen J Kent, Fatima Amanat, Florian Krammer, Kanta Subbarao, Allen C Cheng, Amy W Chung, Mike Catton, Thi Ho Nguyen, Carolien E van de Sandt, Katherine Kedzierska

Journal: Clin Transl Immunology

PubMed ID: 33680466

Doi: 10.1002/cti2.1258

Products & Services: Molecular Biology Reagents

DNA scaffolds enable efficient and tunable functionalization of biomaterials for immune cell modulation

Authors: Huang X, Williams JZ, Chang R, Li Z, Burnett CE, Hernandez-Lopez R, Setiady I, Gai E, Patterson DM, Yu W, Roybal KT, Lim WA, Desai TA

Journal: NATURE NANOTECHNOLOGY

PubMed ID: 33318641

Doi: 10.1038/s41565-020-00813-z

Products & Services: Molecular Biology Reagents

Increased CFTR expression and function from an optimized lentiviral vector for cystic fibrosis gene therapy

Authors: Laura I Marquez Loza, Ashley L Cooney, Qian Dong, Christoph O Randak, Stefano Rivella, Patrick L Sinn, Paul B McCray

Journal: Mol Ther Methods Clin Dev

PubMed ID: 33768133

Doi: 10.1016/j.omtm.2021.02.020

Products & Services: Molecular Biology Reagents

Nanoluciferase complementation-based bioreporter reveals the importance of N-linked glycosylation of SARS-CoV-2 S for viral entry

Authors: Taha Azad, Ragunath Singaravelu, Zaid Taha, Taylor R Jamieson, Stephen Boulton, Mathieu J F Crupi, Nikolas T Martin, Emily E F Brown, Joanna Poutou, Mina Ghahremani, Adrian Pelin, Kazem Nouri, Reza Rezaei, Christopher Boyd Marshall, Masahiro Enomoto, Rozanne Arulanandam, Nouf Alluqmani, Reuben Samson, Anne-Claude Gingras, D William Cameron, Peter A Greer, Carolina S Ilkow, Jean-Simon Diallo, John C Bell

Journal: Mol Ther

PubMed ID: 33578036

Doi: 10.1016/j.ymthe.2021.02.007

Products & Services: Molecular Biology Reagents

Nitrosonisoldipine is a selective inhibitor of inflammatory caspases and protects against pyroptosis and related septic shock

Authors: Qianyue Chen, Jiashuo Zheng, Dingyu Wang, Qiyao Liu, Lulu Kang, Xiang Gao, Zhaoyu Lin

Journal: Eur J Immunol

PubMed ID: 33454984

Doi: 10.1002/eji.202048937

Products & Services: Molecular Biology Reagents

Apaf-1 Pyroptosome Senses Mitochondrial Permeability Transition

Authors: Xu W, Che Y, Zhang Q, Huang H, Ding C, Wang Y, Wang G, Cao L, Hao H

Journal: Cell metabolism

PubMed ID: 33308446

Doi: 10.1016/j.cmet.2020.11.018

Products & Services: Molecular Biology Reagents

A Novel Branched DNA-Based Flowcytometric Method for Single-Cell Characterization of Gene Therapy Products and Expression of Therapeutic Genes

Authors: Laura Garcia-Perez, Marja C J A van Eggermond, Elisa Maietta, Marie-Louise P van der Hoorn, Karin Pike-Overzet, Frank J T Staal

Journal: Front Immunol

PubMed ID: 33584681

Doi: 10.3389/fimmu.2020.607991

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Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs

Authors: Li T, Wu K, Yue Z, Wang Y, Zhang F, Shen H

Journal: Molecular Cell

PubMed ID: 33238160

Doi: 10.1016/j.molcel.2020.10.037

Products & Services: Molecular Biology Reagents

Meiotic Cells Counteract Programmed Retrotransposon Activation via RNA-Binding Translational Repressor Assemblies

Authors: Laureau R, Dyatel A, Dursuk G, Brown S, Adeoye H, Yue JX, De Chiara M, Harris A, Ünal E, Liti G, Adams IR, Berchowitz LE

Journal: Developmental Cell

PubMed ID: 33278343

Doi: 10.1016/j.devcel.2020.11.008

Products & Services: Molecular Biology Reagents