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Nanomolar anti-SARS-CoV-2 Omicron activity of the host-directed TMPRSS2 inhibitor N-0385 and synergistic action with direct-acting antivirals

Authors: Jimena Pérez-Vargas, Gabriel Lemieux, Connor A H Thompson, Antoine Désilets, Siobhan Ennis, Guang Gao, Danielle G Gordon, Annika Lea Schulz, Masahiro Niikura, Ivan Robert Nabi, Mel Krajden, Pierre-Luc Boudreault, Richard Leduc, François Jean

Journal: Antiviral Res

PubMed ID: 38548023

Doi: 10.1016/j.antiviral.2024.105869

Products & Services: Molecular Biology Reagents

HTRA1 disaggregates α-synuclein amyloid fibrils and converts them into non-toxic and seeding incompetent species

Authors: Sheng Chen, Anuradhika Puri, Braxton Bell, Joseph Fritsche, Hector H Palacios, Maurie Balch, Macy L Sprunger, Matthew K Howard, Jeremy J Ryan, Jessica N Haines, Gary J Patti, Albert A Davis, Meredith E Jackrel

Journal: Nat Commun

PubMed ID: 38499535

Doi: 10.1038/s41467-024-46538-8

Products & Services: Molecular Biology Reagents

LysSYL: a broad-spectrum phage endolysin targeting Staphylococcus species and eradicating S aureus biofilms

Authors: He Liu, Xuemei Wei, Zhefen Wang, Xiaonan Huang, Mengyang Li, Zhen Hu, Kexin Zhang, Qiwen Hu, Huagang Peng, Weilong Shang, Yi Yang, Yuting Wang, Shuguang Lu, Xiancai Rao

Journal: Microb Cell Fact

PubMed ID: 38528536

Doi: 10.1186/s12934-024-02359-4

Products & Services: Molecular Biology Reagents

Novel Fragment Inhibitors of PYCR1 from Docking-Guided X-ray Crystallography

Authors: Kaylen R Meeks, Juan Ji , Mykola V Protopopov , Olga O Tarkhanova , Yurii S Moroz , John J Tanner

Journal: J Chem Inf Model

PubMed ID: 38411104

Doi: 10.1021/acs.jcim.3c01879

Products & Services: Molecular Biology Reagents

Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development

Authors: Elena Dvoretskova, May C Ho, Volker Kittke, Florian Neuhaus, Ilaria Vitali, Daniel D Lam, Irene Delgado, Chao Feng, Miguel Torres, Juliane Winkelmann, Christian Mayer

Journal: Nat Neurosci

PubMed ID: 38528203

Doi: 10.1038/s41593-024-01611-9

Products & Services: Molecular Biology Reagents

Construction of recombinant pseudorabies virus expressing PCV2 Cap, PCV3 Cap, and IL-4: investigation of their biological characteristics and immunogenicity

Authors: Yanting Yang, Zhiwen Xu, Qian Tao, Lei Xu, Sirui Gu, Yao Huang, Zheyan Liu, Yang Zhang, Jianhua Wen, Siyuan Lai, Ling Zhu

Journal: Front Immunol

PubMed ID: 38571947

Doi: 10.3389/fimmu.2024.1339387

Products & Services: Molecular Biology Reagents

Expanding the molecular language of protein liquid-liquid phase separation

Authors: Shiv Rekhi, Cristobal Garcia Garcia, Mayur Barai, Azamat Rizuan, Benjamin S Schuster, Kristi L Kiick, Jeetain Mittal

Journal: Nat Chem

PubMed ID: 38553587

Doi: 10.1038/s41557-024-01489-x

Products & Services: Molecular Biology Reagents

An optimised protocol for the expression and purification of adenovirus core protein VII

Authors: Ajani Athukorala, Karla J Helbig, Brian P McSharry, Jade K Forwood, Subir Sarker

Journal: J Virol Methods

PubMed ID: 38432358

Doi: 10.1016/j.jviromet.2024.114907

Products & Services: Molecular Biology Reagents

mmu-miR-374b-5p modulated inflammatory factors via downregulation of C/EBP β/NF-κB signaling in Kupffer cells during Echinococcus multilocularis infection

Authors: Guiting Pu, Yanping Li, Tingli Liu, Hong Li, Liqun Wang, Guoliang Chen, Shanling Cao, Hong Yin, Tharheer Oluwashola Amuda, Xiaola Guo, Xuenong Luo

Journal: Parasit Vectors

PubMed ID: 38553755

Doi: 10.1186/s13071-024-06238-0

Products & Services: Molecular Biology Reagents

Modulation of Primary and Secondary Processes in Tau Fibril Formation by Salt-Induced Dynamics

Authors: Arshad Abdul Vahid, Muhammed Shafeek Oliyantakath Hassan, Allwin Ebenezer Sahayaraj, Ann Teres Babu, Safwa T Kizhakkeduth, Vinesh Vijayan

Journal: ACS Chem Neurosci

PubMed ID: 38433380

Doi: 10.1021/acschemneuro.3c00852

Products & Services: Molecular Biology Reagents