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Discovery of UMI-77 as a novel Ku70/80 inhibitor sensitizing cancer cells to DNA damaging agents in vitro and in vivo

Authors: Xuening Chen, Changkun Chen, Chengmiao Luo, Jianyong Liu, Zhonghui Lin

Journal: Eur J Pharmacol

PubMed ID: 38754534

Doi: 10.1016/j.ejphar.2024.176647

Products & Services: Molecular Biology Reagents

Fibroblast growth factor 21 enhances learning and memory performance in mice by regulating hippocampal L-lactate homeostasis

Authors: Jiaojiao Xie, Jiapin Yan, Keru Ji, Yuejun Guo, Sibei Xu, Danjie Shen, Chen Li, Hongchang Gao, Liangcai Zhao

Journal: Int J Biol Macromol

PubMed ID: 38801850

Doi: 10.1016/j.ijbiomac.2024.132667

Products & Services: Molecular Biology Reagents

Evolution of a novel adrenal cell type that promotes parental care

Authors: Natalie Niepoth, Jennifer R Merritt, Michelle Uminski, Emily Lei, Victoria S Esquibies, Ina B Bando, Kimberly Hernandez, Christoph Gebhardt, Sarah A Wacker, Stefano Lutzu, Asmita Poudel, Kiran K Soma, Stephanie Rudolph, Andres Bendesky

Journal: Nature

PubMed ID: 38750354

Doi: 10.1038/s41586-024-07423-y

Products & Services: Molecular Biology Reagents

Staphylococcal peroxidase inhibitor (SPIN): Residue-level investigation of the helical bundle domain

Authors: Soheila Fatehi, Timothy J Herdendorf, Nicoleta T Ploscariu, Brian V Geisbrecht

Journal: Arch Biochem Biophys

PubMed ID: 38705227

Doi: 10.1016/j.abb.2024.110023

Products & Services: Molecular Biology Reagents

A novel mouse model for investigating α-synuclein aggregates in oligodendrocytes: implications for the glial cytoplasmic inclusions in multiple system atrophy

Authors: Tomoyuki Ishimoto, Miki Oono, Seiji Kaji, Takashi Ayaki, Katsuya Nishida, Itaru Funakawa, Takakuni Maki, Shu-Ichi Matsuzawa, Ryosuke Takahashi, Hodaka Yamakado

Journal: Mol Brain

PubMed ID: 38790036

Doi: 10.1186/s13041-024-01104-7

Products & Services: Molecular Biology Reagents

Kinetic Characterization and Identification of Key Active Site Residues of the L-Aspartate N-Hydroxylase, CreE

Authors: Sydney B Johnson, Hannah Valentino, Pablo Sobrado

Journal: Chembiochem

PubMed ID: 38775737

Doi: 10.1002/cbic.202400350

Products & Services: Molecular Biology Reagents

Intranasal respiratory syncytial virus vaccine attenuated by codon-pair deoptimization of seven open reading frames is genetically stable and elicits mucosal and systemic immunity and protection against challenge virus replication in hamsters

Authors: Megan Levy, Jessica W Chen, Jaclyn A Kaiser, Hong-Su Park, Xueqiao Liu, Lijuan Yang, Celia Santos, Ursula J Buchholz, Cyril Le Nouën

Journal: PLoS Pathog

PubMed ID: 38739647

Doi: 10.1371/journal.ppat.1012198

Products & Services: Molecular Biology Reagents

Divergent effects of olfactory receptors on transient receptor potential vanilloid 1 activation by capsaicin and eugenol

Authors: Sakura Moriyama, Yukie Takita, Shuji Hinuma, Shun'ichi Kuroda

Journal: Biosci Biotechnol Biochem

PubMed ID: 38734894

Doi: 10.1093/bbb/zbae060

Products & Services: Molecular Biology Reagents

HSD17B13 liquid-liquid phase separation promotes leukocyte adhesion in chronic liver inflammation

Authors: Jing Ye, Xiyu Huang, Manman Yuan, Jinglin Wang, Ru Jia, Tianyi Wang, Yang Tan, Shun Zhu, Qiang Xu, Xingxin Wu

Journal: J Mol Cell Biol

PubMed ID: 38692847

Doi: 10.1093/jmcb/mjae018

Products & Services: Molecular Biology Reagents

SFTSV nucleoprotein mediates DNA sensor cGAS degradation to suppress cGAS-dependent antiviral responses

Authors: Ze-Zheng Jiang, Min Chu, Li-Na Yan, Wen-Kang Zhang, Bang Li, Jiao Xu, Zhong-Xin Zhao, Hui-Ju Han, Chuan-Min Zhou, Xue-Jie Yu

Journal: Microbiol Spectr

PubMed ID: 38712963

Doi: 10.1128/spectrum.03796-23

Products & Services: Molecular Biology Reagents