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Nivolumab plus ipilimumab induce hyper-progression in renal medullary carcinoma: results of a phase II trial and preclinical evidence
Authors: Melinda Soeung, Xinmiao Yan, Ciro Zanca, Jing Qian, Menuka Karki, Fei Duan, Hania Khan, Li Zhang, David H Peng, Mariah Williams, Rong He, Ziheng Chen, Luigi Perelli, Jianfeng Chen, Rebecca S Tidwell, Pankaj K Chauhan, Courtney N Le, Truong N A Lam, Nirjar Bhattacharya, Rutvi Shah, I-Lin Ho, Jason P Gay, Caroline C Carrillo, Ningping Feng, Kang Le, Guang Gao, Teresa L Perry, Faika Mseeh, Yongying Jiang, Quanyun A Xu, Niki Marie Zacharias, Rahul A Sheth, Tharakeswara K Bathala, Priya Rao, Najat C Daw, Durga N Tripathi, Cheryl L Walker, Mohammad M Mohammad, Jianhua Zhang, Guangchun Han, Yanshuo Chu, Ruiping Wang, Minghao Dang, Enyu Dai, Fuduan Peng, Yunhe Liu, Akshaya Jadhav, Wenhua Lang, Claudio A Arrechedera, Leticia Campos Clemente, Edwin R Parra, Hsinyi Lu, Cara L Haymaker, Ignacio I Wistuba, Andrew Futreal, Andrea Viale, Michael J Soth, Philip Jones, Joseph R Marszalek, Timothy Heffernan, Giulio F Draetta, Nizar M Tannir, Jianjun Gao, Linghua Wang, Giannicola Genovese, Pavlos Msaouel
Journal: Nature Communications
PubMed ID: 41290625
Doi: 10.1038/s41467-025-65462-z.
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Design and structural basis of selective 1,4-dihydropyridine inhibitors of the calcium-activated potassium channel KCa3.1
Authors: Seow Theng Ong, Young-Woo Nam, Joshua A Nasburg, Alena Ramanishka, Xuan Rui Ng, Zhong Zhuang, Stephanie Shee Min Goay, Hai M Nguyen, Latika Singh, Vikrant Singh, Alicia Rivera, M Elaine Eyster, Yang Xu, Seth L Alper, Heike Wulff, Miao Zhang, K George Chandy
Journal: Proc Natl Acad Sci U S A
PubMed ID: 40294255
Doi: 10.1073/pnas.2425494122
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Re-adenylation by TENT5A enhances efficacy of SARS-CoV-2 mRNA vaccines
Authors: Paweł S Krawczyk, Michał Mazur, Wiktoria Orzeł, Olga Gewartowska, Sebastian Jeleń, Wiktor Antczak, Karolina Kasztelan, Aleksandra Brouze, Katarzyna Matylla-Kulińska, Natalia Gumińska, Bartosz Tarkowski, Ewelina P Owczarek, Kamila Affek, Paweł Turowski, Agnieszka Tudek, Małgorzata Sroka, Tomasz Śpiewla, Monika Kusio-Kobiałka, Aleksandra Wesołowska, Dominika Nowis, Jakub Golab, Joanna Kowalska, Jacek Jemielity, Andrzej Dziembowski, Seweryn Mroczek
Journal: Nature
PubMed ID: 40240603
Doi: 10.1038/s41586-025-08842-1
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CodonTransformer: a multispecies codon optimizer using context-aware neural networks
Authors: Adibvafa Fallahpour, Vincent Gureghian, Guillaume J. Filion, Ariel B. Lindner & Amir Pandi
Journal: Nature Communications
PubMed ID: 40180930
Doi: 10.1038/s41467-025-58588-7
Products & Services: Molecular Biology Tools   
Integration of multi-omics data accelerates molecular analysis of common wheat traits
Authors: Ning Zhang, Li Tang, Songgang Li, Lu Liu, Mengjuan Gao, Sisheng Wang, Daiying Chen, Yichao Zhao, Ruiqing Zheng, Armin Soleymaniniya, Lingran Zhang, Wenkang Wang, Xia Yang, Yan Ren, Congwei Sun, Mathias Wilhelm, Daowen Wang, Min Li, Feng Chen
Journal: Nature Communications
PubMed ID: 40038279
Doi: 10.1038/s41467-025-57550-x
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Lipopolysaccharide modification enhances the inhibitory effect of clodronate liposomes on hepatic fibrosis by depletion of macrophages and hepatic stellate cells
Authors: Luyao Zhang, Min Tao, Hengyan Zhang, Shichao Zhang, Xiaojuan Hou, Chen Zong, Gangqi Sun, Shiyao Feng, Haixin Yan, Ying Lu, Xue Yang, Lixin Wei, Li Zhang
Journal: Chem Biol Interact
PubMed ID: 38663797
Doi: 10.1016/j.cbi.2024.111015
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Chitosan-LeoA-DNA Nanoparticles Promoted the Efficacy of Novel LeoA-DNA Vaccination on Mice Against Helicobacter pylori
Authors: Zahra Ahmadzadeh Chaleshtori, Ali Asghar Rastegari, Hashem Nayeri, Abbas Doosti
Journal: Curr Microbiol
PubMed ID: 38558085
Doi: 10.1007/s00284-024-03642-8
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Enhancing precision medicine: Bispecific antibody-mediated targeted delivery of lipid nanoparticles for potential cancer therapy
Authors: Yue Zhang, Xiaoyan Gu, Lili Huang, Yani Yang, Jun He
Journal: Int J Pharm
PubMed ID: 38467208
Doi: 10.1016/j.ijpharm.2024.123990
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Oral administration of DNA alginate nanovaccine induced immune-protection against Helicobacter pylori in Balb/C mice
Authors: Arezo Kaveh-Samani, Samaneh Dalali, Fatemeh Kaviani, Tohid Piri-Gharaghie, Abbas Doosti
Journal: BMC Immunol
PubMed ID: 38310250
Doi: 10.1186/s12865-024-00602-6
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Evolutionary preservation of CpG dinucleotides in RAG1 may elucidate the relatively high rate of methylation-mediated mutagenesis of RAG1 transposase
Authors: Mariam M Fawzy, Maiiada H Nazmy, Azza A K El-Sheikh, Moustafa Fathy
Journal: Immunol Res
PubMed ID: 38240953
Doi: 10.1007/s12026-023-09451-8
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