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Regression of EGFR positive established solid tumors in mice with the conditionally active T cell engager TAK-186

Authors: Danielle E Dettling, Eilene Kwok, Lucy Quach, Aakash Datt, Jeremiah D Degenhardt, Anand Panchal, Pui Seto, Jessica L Krakow, Russell Wall, Brian J Hillier, Ying Zhu, Maia Vinogradova, Robert B DuBridge, Chad May

Journal: J Immunother Cancer

PubMed ID: 35728872

Doi: 10.1136/jitc-2021-004336

Products & Services: Proteins, Expression, Isolation and Analysis

Molecular insights into intra-complex signal transmission during stressosome activation

Authors: Algirdas Miksys, Lifei Fu, M Gregor Madej, Duarte N Guerreiro, Susann Kaltwasser, Maria Conway, Sema Ejder, Astrid Bruckmann, Jon Marles-Wright, Richard J Lewis, Conor O'Byrne, Jan Pané-Farré, Christine Ziegler

Journal: Commun Biol

PubMed ID: 35760945

Doi: 10.1038/s42003-022-03549-9

Products & Services: Proteins, Expression, Isolation and Analysis

Catalytic Properties of Caseinolytic Protease Subunit of and Its Inhibition by a Member of δ-Lactone, Hyptolide

Authors: Cahyo Budiman, Raimalynah Abd Razak, Angelesa Runin Anak Unggit, Rafida Razali, Meiny Suzery, Ruzaidi Azli Mohd Mokhtar, Ping-Chin Lee, Didik Huswo Utomo

Journal: Molecules

PubMed ID: 35744912

Doi: 10.3390/molecules27123787

Products & Services: Proteins, Expression, Isolation and Analysis

Molecular basis of Tick Born encephalitis virus NS5 mediated subversion of apico-basal cell polarity signalling

Authors: Airah Javorsky, Patrick O Humbert, Marc Kvansakul

Journal: Biochem J

PubMed ID: 35670457

Doi: 10.1042/BCJ20220037

Products & Services: Proteins, Expression, Isolation and Analysis

Transcriptional and metabolic remodeling in clear cell renal cell carcinoma caused by ATF4 activation and the integrated stress response (ISR)

Authors: Johannes C van der Mijn, Qiuying Chen, Kristian B Laursen, Francesca Khani, Xiaofei Wang, Princesca Dorsaint, Andrea Sboner, Steven S Gross, David M Nanus, Lorraine J Gudas

Journal: Mol Carcinog

PubMed ID: 35726553

Doi: 10.1002/mc.23437

Products & Services: Proteins, Expression, Isolation and Analysis

A prion-like domain of TFEB mediates the co-aggregation of TFEB and mHTT

Authors: Junsheng Yang, Huilin Xu, Chaoyue Zhang, Xiaotong Yang, Weijie Cai, Xiaoli Chen

Journal: Autophagy

PubMed ID: 35635192

Doi: 10.1080/15548627.2022.2083857

Products & Services: Proteins, Expression, Isolation and Analysis

Unbalanced regulation of Sec22b and Ykt6 blocks autophagosome axonal retrograde flux in neuronal ischemia-reperfusion injury

Authors: Haiying Li, Xiang Li, Zhongmou Xu, Jinxin Lu, Chang Cao, Wanchun You, Zhengquan Yu, Haitao Shen, Gang Chen

Journal: J Neurosci

PubMed ID: 35654605

Doi: 10.1523/JNEUROSCI.2030-21.2022

Products & Services: Proteins, Expression, Isolation and Analysis

Aberrant DNA hydroxymethylation reshapes transcription factor binding in myeloid neoplasms

Authors: Jia Li, Tingting Hong, Yue Wei, Lei Guo, Minjung Lee, Hui Yang, Caleb Class, Yaling Yang, Xiaoqiong Wang, Hua He, Stefan Siwko, M James You, Yubin Zhou, Guillermo Garcia-Manero, Yun Huang

Journal: Clin Epigenetics

PubMed ID: 35765052

Doi: 10.1186/s13148-022-01297-5

Products & Services: Proteins, Expression, Isolation and Analysis

Metal cofactor stabilization by a partner protein is a widespread strategy employed for amidase activation

Authors: Julia E Page, Meredith A Skiba, Truc Do, Andrew C Kruse, Suzanne Walker

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35733252

Doi: 10.1073/pnas.2201141119

Products & Services: Proteins, Expression, Isolation and Analysis

The PRMT5-LSD1 axis confers Slug dual transcriptional activities and promotes breast cancer progression

Authors: Jianchao Zhang, Xiaokai Fan, Yunfan Zhou, Liang Chen, Hai Rao