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De novo biosynthesis of garbanzol and fustin in Streptomyces albus based on a potential flavanone 3-hydroxylase with 2-hydroxylase side activity

Authors: Laura Marín, Ignacio Gutiérrez-Del-Río, Claudio Jesús Villar, Felipe Lombó

Journal: Microb Biotechnol

PubMed ID: 34216097

Doi: 10.1111/1751-7915.13874

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Condition-dependent structural collapse in the intrinsically disordered N-terminal domain of prion protein

Authors: Eric H-L Chen, Kuei-Ming Lin, Jason C Sang, Meng-Ru Ho, Chih-Hsuan Lee, Orion Shih, Chun-Jen Su, Yi-Qi Yeh, U-Ser Jeng, Rita P-Y Chen

Journal: IUBMB Life

PubMed ID: 34288372

Doi: 10.1002/iub.2528

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Evolution of a σ-(c-di-GMP)-anti-σ switch

Authors: Maria A Schumacher, Kelley A Gallagher, Neil A Holmes, Govind Chandra, Max Henderson, David T Kysela, Richard G Brennan, Mark J Buttner

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34290147

Doi: 10.1073/pnas.2105447118

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Design, synthesis, biological evaluation and structural characterization of novel GEBR library PDE4D inhibitors

Authors: Chiara Brullo, Federica Rapetti, Sara Abbate, Tommaso Prosdocimi, Archimede Torretta, Marta Semrau, Matteo Massa, Silvana Alfei, Paola Storici, Emilio Parisini, Olga Bruno

Journal: Eur J Med Chem

PubMed ID: 34171658

Doi: 10.1016/j.ejmech.2021.113638

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Characterization of an Atypical Hsp70 Demonstrates Its Cytosolic-Nuclear Localization and Modulation by Quercetin and Methylene Blue

Authors: Adélle Burger, Paula Macucule-Tinga, Stephen John Bentley, Michael Hans Ludewig, Ndumiso Nhlakanipho Mhlongo, Addmore Shonhai, Aileen Boshoff

Journal: Int J Mol Sci

PubMed ID: 34202520

Doi: 10.3390/ijms22136776

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Development of a Mini-Replicon-Based Reverse-Genetics System for Rice Stripe Tenuivirus

Authors: Mingfeng Feng, Luyao Li, Ruixiang Cheng, Yulong Yuan, Yongxin Dong, Minglong Chen, Rong Guo, Min Yao, Yi Xu, Yijun Zhou, Jianxiang Wu, Xin Shun Ding, Xueping Zhou, Xiaorong Tao

Journal: J Virol

PubMed ID: 33952642

Doi: 10.1128/JVI.00589-21

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A rapid cell-free expression and screening platform for antibody discovery

Authors: Andrew C. Hunt; Bastian V geli; Ahmed O. Hassan; Laura Guerrero; Weston Kightlinger; Danielle J. Yoesep; Antje Kr ger; Madison DeWinter; Michael S. Diamond; Ashty S. Karim; Michael C. Jewett

Journal: Nature Communications

PubMed ID: 37400446

Doi: 10.1038/s41467-023-38965-w

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Focused peptide library screening as a route to a superior affinity ligand for antibody purification

Authors: Krištof Bozovičar, Barbara Jenko Bizjan, Anže Meden, Jernej Kovač, Tomaž Bratkovič

Journal: Sci Rep

PubMed ID: 34079028

Doi: 10.1038/s41598-021-91208-0

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High-resolution structure of the vWF A1 domain in complex with caplacizumab, the first nanobody-based medicine for treating acquired TTP

Authors: Hyun Tae Lee, Ui Beom Park, Tae Jun Jeong, Nahyeon Gu, Sang Hyung Lee, Yujin Kim, Yong-Seok Heo

Journal: Biochem Biophys Res Commun

PubMed ID: 34144500

Doi: 10.1016/j.bbrc.2021.06.030

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Canine Transforming Growth Factor-β Receptor 2-Ig: A Potential Candidate Biologic for Melanoma Treatment That Reverses Transforming Growth Factor-β1 Immunosuppression

Authors: Hiroto Takeuchi, Satoru Konnai, Naoya Maekawa, Satoshi Takagi, Hiroshi Ohta, Noboru Sasaki, Sangho Kim, Tomohiro Okagawa, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi

Journal: Front Vet Sci

PubMed ID: 34195245

Doi: 10.3389/fvets.2021.656715

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