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Crystal structures of Ryanodine Receptor reveal dantrolene and azumolene interactions guiding inhibitor development

Authors: Hadiatullah Hadiatullah, Lianyun Lin, Zhiyan Wang, Rajamanikandan Sundarraj, Qing Wang, Xinru Lai, Nagomi Kurebayashi, Takuya Kobayashi, Toshiko Yamazawa, Yu Seby Chen, Wenlan Wang, Hongxia Zhao, Yiqing Yin, Takashi Murayama, Filip Van Petegem, Zhiguang Yuchi

Journal: Nature Communications

PubMed ID: 41253812

Doi: 10.1038/s41467-025-65096-1.

Products & Services: Protein and Antibody Isolation

Structural insight into bicarbonate-mediated carboxylation by human vitamin K-dependent carboxylase

Authors: Ke Wu, Zheng Wang, Deqiang Yao, Shaobai Li, Xiaozhu Wang, Yuanyuan Zhang, Mi Cao, Yafeng Shen, Shunpeng Xing, Jian Wu, Ming Lei, Pengfei Lan

Journal: Nature Communications

PubMed ID: 41290650

Doi: 10.1038/s41467-025-65488-3.

Products & Services: Protein and Antibody Isolation

Structural insights into antagonist recognition by the vasopressin V2 receptor

Authors: Tianwei Zhang, Hongli Liu, Chongzhao You, Yixiao Zhang, Youwei Xu, Benxun Pan, Canrong Wu, Sanshan Jin, Yu-Ling Yin, Kai Wu, Yue Chen, Hong Sun, Yuan Si, Yangxia Tan, Wanchao Yin, H Eric Xu, Dong Guo, Yi Jiang

Journal: Nature Communications

PubMed ID: 41188237

Doi: 10.1038/s41467-025-64735-x

Products & Services: Protein and Antibody Isolation

Enabling Open Machine Learning of Deoxyribonucleic Acid-Encoded Library Selections to Accelerate the Discovery of Small Molecule Protein Binders

Authors: James Wellnitz; Shabbir Ahmad; Nabin Bagale; Xuemin Cheng; Jermiah Joseph; Hong Zeng; Albina Bolotokova; Aiping Dong; Shaghayegh Reza; Pegah Ghiabi; Elisa Gibson; Guiping Tu; Xianyang Li; Jian Liu; Dengfeng Dou; Jin Li; Timothy L. Foley; Anthony R. Harris; Jacquelyn L. Klug-McLeod; Jisun Lee; Zsofia Lengyel-Zhand; Justin I. Montgomery; Sylvie Sakata; Jinzhi Zhang; Hongyao Zhu; Dafydd R. Owen; Rachel J. Harding; Aled M. Edwards; Benjamin Haibe-Kains; Levon Halabelian; Alexander Tropsha; Rafael M. Cou ago

Journal: Journal of Medicinal Chemistry

PubMed ID: 41047897

Doi: 10.1021/acs.jmedchem.5c01972

Products & Services: Protein and Antibody Isolation

De novo designed voltage-gated anion channels suppress neuron firing

Authors: Chen Zhou, Huican Li, Jiaxing Wang, Cheng Qian, Hui Xiong, Zhilin Chu, Qiming Shao, Xuan Li, Shijin Sun, Ke Sun, Aiqin Zhu, Jiawei Wang, Xueqin Jin, Fan Yang, Tamer M Gamal El-Din, Bo Li, Jing Huang, Kun Wu, Peilong Lu

Journal: Cell

PubMed ID: 41106381

Doi: 10.1016/j.cell.2025.09.023

Products & Services: Protein and Antibody Isolation

RNA replicon vaccination confers long-lasting protection against H5N1 avian influenza in 23 zoo bird species

Authors: Marion Stettler, Stefan Hoby, Christian Wenker, Fabia Wyss, Elisabeth Heiderich, Lisa Butticaz, Nicolas Ruggli, Karin Darpel & Gert Zimmer

Journal: Nature Communications

PubMed ID: 41115934

Doi: 10.1038/s41467-025-64301-5

Products & Services: Protein Electrophoresis and Western

Metabolic regulation of behavior by the intestinal enzyme FMO-2

Authors: Elizabeth S Kitto, Safa Beydoun, Ella Henry, Megan L Schaller, Mira Bhandari, Sarah A Easow, Angela M Tuckowski, Marshall B Howington, Ajay Bhat, Aditya Sridhar, Eugene Chung, Charles R Evans, Scott F Leiser

Journal: SCIENCE ADVANCES

PubMed ID: 41134904

Doi: 10.1126/sciadv.adx3018

Products & Services: Recombinant Proteins

Simultaneous Monitoring of Intracellular Glucose and Extracellular Lactate in Single Cells to Assess Cell Tumorigenicity

Authors: Hui Liu, Yu Liu, Songqin Liu, Yafeng Wu

Journal: Analytical Chemistry

PubMed ID: 41035132

Doi: 10.1021/acs.analchem.5c03740

Products & Services: Recombinant Proteins

A Robust, High-Titer, Semi-Automated, and In-Culture Antibody-Capturing Transient CHO Platform Technology

Authors: Lauren Gebhardt, Molica Abel, Jing Zhou, Audrey M Vogt, Bo Hee Shin, Sarah L Herrick Wagman, Ana Santos, Jerome Puginier, Florian M Wurm, Maria J Wurm, Guoying Grace Yan, Adedolapo Adeniyi, Sean K H Lim, Will Somers, Laura Lin, Aaron M D'Antona, Xiaotian Zhong

Journal: Antibodies

PubMed ID: 41133681

Doi: 10.3390/antib 14040087

Products & Services: Protein and Antibody Isolation

T cell cholesterol transport links intestinal immune responses to dietary lipid absorption

Authors: Yajing Gao, John P Kennelly, Xu Xiao, Emily Whang, Alessandra Ferrari, Alexander H Bedard, Julia J Mack, Alexander Nguyen, Sonal Srikanth, Thomas Weston, Lauren F Uchiyama, Whitaker Cohn, Danielle H Cho, Min Sub Lee, Julian Whitelegge, Yousang Gwack, Stephen G Young, Steven J Bensinger, Peter Tontonoz

Journal: Science

PubMed ID: 41066556

Doi: 10.1126/science.adt4169

Products & Services: Recombinant Proteins