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Multi-level ROS regulation to activate innate and adaptive immune therapies

Authors: Ke-Ke Feng, Cheng-Lei Li, Yi-Fan Tu, Shi-Cheng Tian, Rui Xiong, Bai-Sheng Sa, Jing-Wei Shao

Journal: Chemical Engineering Journal

Doi: doi.org/10.1016/j.cej.2025.163429

Products & Services: Gene Synthesis

Deep Proteomic Profiling of the Intra-Golgi Trafficking Intermediates

Authors: Farhana Taher Sumya , Walter S Aragon-Ramirez , Vladimir V Lupashin

Journal: Molecular biology of the cell

PubMed ID: 40397568

Doi: 10.1091/mbc.E24-12-0556

Products & Services: Gene Synthesis

FLT201, a novel liver-directed AAV gene therapy candidate for Gaucher disease type 1

Authors: Fabrizio Comper, Carlos J Miranda, Benjamin Liou, Tihomir Dodev, Jey M Jeyakumar, Miriam Canavese, Clement Cocita, Khashayar Khoshrou, Gustavo Tiscornia, Elisa Chisari, Emmaline Stotter, Erald Shehu, Sudharsan Sridharan, I-Mei Yu, Jalpa Pandya, Jaminder Khinder, Natalie Northcott, Petya Kalcheva, Samantha Correia, Ying Sun, Allison P Dane, Rose Sheridan, Amit C Nathwani, Romuald Corbau

Journal: Molecular Therapy

PubMed ID: 40340248

Doi: 10.1016/j.ymthe.2025.05.003

Products & Services: Gene Synthesis

LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers

Authors: Chendi Li, Mohammed Usman Syed, Anahita Nimbalkar, Yi Shen, Melissa D Vieira, Cameron Fraser, Zintis Inde, Xingping Qin, Jian Ouyang, Johannes Kreuzer, Sarah E Clark, Grace Kelley, Emily M Hensley, Robert Morris, Raul Lazaro, Brian Belmonte, Audris Oh, Makeba Walcott, Christopher S Nabel, Sean Caenepeel, Anne Y Saiki, Karen Rex, J Russell Lipford, Rebecca S Heist, Jessica J Lin, Wilhelm Haas, Kristopher Sarosiek, Paul E Hughes, Aaron N Hata

Journal: Nature Communications

PubMed ID: 40316540

Doi: 10.1038/s41467-025-58753-y

Products & Services: Gene Synthesis

Structure and mechanism of human vesicular polyamine transporter

Authors: Yi Guo, Ge Yang, Haijiao Liu, Jin Chai, Jie Chen, John Shanklin, Qun Liu, Bin Liu, Min Lu

Journal: Nature Communications

PubMed ID: 40319071

Doi: 10.1038/s41467-025-59549-w

Products & Services: Gene Synthesis

Tandem ketone reduction in pepstatin biosynthesis reveals an F420H2-dependent statine pathway

Authors: Jingjun Mo, Asfandyar Sikandar, Haowen Zhao, Ghader Bashiri, Liujie Huo, Martin Empting, Rolf Müller, Chengzhang Fu

Journal: Nature Communications

PubMed ID: 40374670

Doi: 10.1038/s41467-025-59785-0

Products & Services: Gene Synthesis

Freezing induced incorporation of betaine in lipid nanoparticles enhances mRNA delivery

Authors: Xingdi Cheng, Xia Zheng, Kun Tao, Haonan Huo, Zhang Liu, Xueguang Lu, Jianjun Wang

Journal: Nature Communications

PubMed ID: 40394015

Doi: 10.1038/s41467-025-60040-9

Products & Services: Gene Synthesis

Structural visualization of HECT-type E3 ligase Ufd4 accepting and transferring

Authors: Xiangwei Wu, Huasong Ai, Junxiong Mao, Hongyi Cai, Lu-Jun Liang, Zebin Tong, Zhiheng Deng, Qingyun Zheng, Lei Liu, Man Pan

Journal: nature COMMUNICATION

PubMed ID: 40341121

Doi: doi.org/10.1038/s41467-025-59569-6

Products & Services: Gene Synthesis Codon Optimization PCR Cloning and Subcloning Mutagenesis Services

An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse models

Authors: Aina Karen Anthi, Anette Kolderup, Eline Benno Vaage, Malin Bern, Sopisa Benjakul, Elias Tjärnhage, Fulgencio Ruso-Julve, Kjell-Rune Jensen, Heidrun Elisabeth Lode, Marina Vaysburd, Jeannette Nilsen, Marie Leangen Herigstad, Siri Aastedatter Sakya, Lisa Tietze, Diego Pilati, Mari Nyquist-Andersen, Mirjam Dürkoop, Torleif Tollefsrud Gjølberg, Linghang Peng, Stian Foss, Morten C Moe, Benjamin E Low, Michael V Wiles, David Nemazee, Frode L Jahnsen, John Torgils Vaage, Kenneth A Howard, Inger Sandlie, Leo C James, Gunnveig Grødeland, Fridtjof Lund-Johansen, Jan Terje Andersen

Journal: Nature Communications

PubMed ID: 40312392

Doi: 10.1038/s41467-025-59353-6

Products & Services: Gene Synthesis

Dual inhibition of DNA-PK and Polϴ boosts precision of diverse prime editing systems

Authors: Louis C Dacquay, Panagiotis Antoniou, Astrid Mentani, Niklas Selfjord, Hanna Mårtensson, Pei-Pei Hsieh, Salman Mustfa, George Thom, Sandra Wimberger, Mike Firth, Nina Akrap, Marcello Maresca, Martin Peterka

Journal: Nature Communications

PubMed ID: 40341582

Doi: 10.1038/s41467-025-59708-z

Products & Services: Gene Synthesis