目录产品 » IL-18 R1/CD218a, His, Cynomolgus
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IL-18 R1/CD218a, His, Cynomolgus

Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing Th1 cells, which increase IFN-γ production in response to IL-18 stimulation.
￥3500
Z04830-100

产品简介
Species Cynomolgus
Protein Construction
IL-18 R1/CD218a (Cys22-Gly329)
Accession # A0A2K5V3J9		 His
N-term C-term
Purity > 95% as determined by Bis-­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity IL-18 R1/CD218a, His, Cynomolgus captured on CM5 Chip via anti­-his antibody can bind Human IL­-18, No Tag in BLI assay (Gator® Prime). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 36.45 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
IL-18 R1/CD218a, His, Cynomolgus

The purity of IL-18 R1/CD218a, His, Cynomolgus is greater than 95% as determined by SEC-HPLC. »

IL-18 R1/CD218a, His, Cynomolgus

IL-18 R1/CD218a, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

IL-18 R1/CD218a, His, Cynomolgus

IL-18 R1/CD218a, His, Cynomolgus, His Tag captured on CM5 Chip via anti-his antibody can bind Human IL-18, No Tag with an affinity constant of 2.02 nM as determined in SPR assay (Biacore T200). »

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技术背景
Target Background Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing Th1 cells, which increase IFN-γ production in response to IL-18 stimulation.
Synonyms CD218a; IL18Ra; IL18R1; IL1RRP; IL-1 R5; IL-1 Rrp; IL-18 R alpha; IL-18 R1; IL-18Ra
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.