目录产品 » IL-17F, His, Cynomolgus
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IL-17F, His, Cynomolgus

The Interleukin 17 (IL-17) family proteins, comprising six members (IL-17A through IL-17F), are secreted, structurally related proteins that share a conserved cystine-knot fold near the C-terminus, but have considerable sequence divergence at the N‑terminus.IL-17F is ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover.
￥3500
Z04829-100

产品简介
Species Cynomolgus
Protein Construction
IL-17F (Arg31-Gln163)
Accession # G7P4V0-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Human IL­17R alpha, hFc Tag captured on CM5 Chip via Protein A can bind IL-17F, His, Cynomolgus in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 16.1 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 23-28 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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图例
IL-17F, His, Cynomolgus

The purity of IL-17F, His, Cynomolgus is greater than 95% as determined by SEC-HPLC. »

IL-17F, His, Cynomolgus

IL-17F, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

IL-17F, His, Cynomolgus

Human IL-17R alpha, hFc Tag captured on CM5 Chip via Protein A can bind IL-17F, His, Cynomolgus, His Tag with an affinity constant of 0.13 μM as determined in SPR assay (Biacore T200). »

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技术背景
Target Background The Interleukin 17 (IL-17) family proteins, comprising six members (IL-17A through IL-17F), are secreted, structurally related proteins that share a conserved cystine-knot fold near the C-terminus, but have considerable sequence divergence at the N‑terminus.IL-17F is ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover.
Synonyms Cytokine ML-1; IL17F; IL-17F; IL24; IL-24; CANDF6; IL-17F; ML1
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.