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IL-13, His, Cynomolgus

Interleukin-13 (IL-13) is a monomeric 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.
￥3500
Z04826-100

产品简介
Species Cynomolgus
Protein Construction
His IL-13 (Ser19-Asn132)
Accession # Q0PW92
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 13.59 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 30-45 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
IL-13, His, Cynomolgus

Loaded IL-13, His, Cynomolgus, His Tag on Anti-His-Biosensor can bind Human IL-13Ra2, hFc Tag with an affinity constant of 0.14 µM as determined in BLI assay (Gator® Prime). »

IL-13, His, Cynomolgus

Immobilized IL-13, His, Cynomolgus, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for Human IL-13Ra2, hFc Tag with the EC50 of 75.8ng/ml determined by ELISA. »

IL-13, His, Cynomolgus

The purity of IL-13, His, Cynomolgus is greater than 95% as determined by SEC-HPLC. »

IL-13, His, Cynomolgus

IL-13, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

IL-13, His, Cynomolgus

IL-13, His, Cynomolgus, His Tag immobilized on CM5 Chip can bind Cynomolgus IL-13, His Tag with an affinity constant of 21.16 nM as determined in SPR assay (Biacore T200). »

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技术背景
Target Background Interleukin-13 (IL-13) is a monomeric 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergy, cancer, and tissue fibrosis. It is secreted by several helper T cell subsets, NK cells, mast cells, eosinophils, basophils, and visceral smooth muscle cells. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages.
Synonyms interleukin 13; NC30; P600; ALRH; BHR1; MGC116786; MGC116788; MGC116789
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.