| ￥3500 | |
| Z04823-100 | |
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| Species | Cynomolgus | ||||
| Protein Construction |
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| Purity | > 95% as determined by BisTris PAGE | ||||
| Endotoxin Level | Less than 1EU per μg by the LAL method. | ||||
| Biological Activity | Loaded Human IL-11 R alpha, hFc Tag on ProA-Biosensor can bind IL-11, His, Cynomolgus in BLI assay (Gator® Prime). Test result was comparable to standard batch. | ||||
| Expression System | HEK293 | ||||
| Theoretical Molecular Weight | 20.48 kDa | ||||
| Apparent Molecular Weight | Due to glycosylation, the protein migrates to 21-25 kDa based on Bis-Tris PAGE result. | ||||
| Formulation | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). | ||||
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. | ||||
| Storage & Stability | Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles. |
The purity of IL-11, His, Cynomolgus is greater than 95% as determined by SEC-HPLC. »
IL-11, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »
Human IL-11 R alpha, hFc Tag captured on CM5 Chip via Protein A can bind IL-11, His, Cynomolgus, His Tag with an affinity constant of 0.25 nM as determined in SPR assay (Biacore T200). »
| Target Background | Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. IL-11 and its receptor, IL-11Ra, are expressed in human cancers,human cancer cells expressed a functional IL-11Ra subunit, which triggered signal transduction either by exogenous recombinant human IL-11 or by autocrine production of IL-11 in cells cultured under hypoxic conditions. |
| Synonyms | Interleukin-11;IL11;Adipogenesis inhibitory factor;AGIF;INN: Oprelvekin;Oprelvekin;IL-11Oprelvekin;interleukin 11;interleukin-11 |
For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.
