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IL-10 R alpha, His, Cynomolgus

The interleukin-10 receptor alpha (IL10RA) gene codes for the alpha chain of the IL-10 receptor which binds the cytokine IL-10. IL-10 is an anti-inflammatory cytokine with immunoregulatory function during the pathogenesis of many inflammatory disorders in livestock, including Johne's disease (JD). JD is a chronic enteritis in cattle caused by Mycobacterium avium subsp. paratuberculosis (MAP) and is responsible for significant economic losses to the dairy industry. Several candidate genes including IL10RA have been found to be associated with JD.
￥3500
Z04822-100

产品简介
Species Cynomolgus
Protein Construction
IL-10 R alpha (His22-Asn233)
Accession # A0A2K5WJ66		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 25.34 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 45-60 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
IL-10 R Alpha, His, Cynomolgus

Immobilized Human IL-10, No Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for IL-10 R alpha, His, Cynomolgus, His Tag with the EC50 of 2.4ng/ml determined by ELISA. »

IL-10 R Alpha, His, Cynomolgus

The purity of IL-10 R alpha, His, Cynomolgus is greater than 95% as determined by SEC-HPLC. »

IL-10 R Alpha, His, Cynomolgus

IL-10 R alpha, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

IL-10 R Alpha, His, Cynomolgus

IL-10 R alpha, His, Cynomolgus, His Tag immobilized on CM5 Chip can bind Cynomolgus IL-10, His Tag with an affinity constant of 0.93 nM as determined in SPR assay (Biacore T200). »

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技术背景
Target Background The interleukin-10 receptor alpha (IL10RA) gene codes for the alpha chain of the IL-10 receptor which binds the cytokine IL-10. IL-10 is an anti-inflammatory cytokine with immunoregulatory function during the pathogenesis of many inflammatory disorders in livestock, including Johne's disease (JD). JD is a chronic enteritis in cattle caused by Mycobacterium avium subsp. paratuberculosis (MAP) and is responsible for significant economic losses to the dairy industry. Several candidate genes including IL10RA have been found to be associated with JD.
Synonyms IL-10RA; IL10RA; IL10R; IL-10R1; IL-10R subunit 1; CDw210a; HIL-10R; IBD28; IL-10 R alpha
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.