目录产品 » CDH17/Cadherin 17, His, Cynomolgus
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CDH17/Cadherin 17, His, Cynomolgus

Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
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产品简介
Species Cynomolgus
Protein Construction
CDH17/Cadherin 17 (Gln23-Thr784)
Accession # XP_005563762.2		 His
N-term C-term
Purity > 90% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1 EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 85.57 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 95-115 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
CDH17/Cadherin 17, His, Cynomolgus

Loaded Anti-CDH17 Ab., hFc-Avi Tag on ProA-Biosensor can bind CDH17/Cadherin 17, His, Cynomolgus, His Tag with an affinity constant of 9.78 nM as determined in BLI assay (Gator® Prime). »

CDH17/Cadherin 17, His, Cynomolgus

Immobilized CDH17/Cadherin 17, His, Cynomolgus, His Tag at 1 μg/ml (100 μI/well) on the plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 3.4ng/ml determined by ELISA. »

CDH17/Cadherin 17, His, Cynomolgus

The purity of CDH17/Cadherin 17, His, Cynomolgus is greater than 90% as determined by SEC-HPLC. »

CDH17/Cadherin 17, His, Cynomolgus

CDH17/Cadherin 17, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 90%. »

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技术背景
Target Background Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
Synonyms Cadherin-17; BILL-cadherin; LI-cadherin; P130; Cdh17; CDH16; HPT-1; cadherin-16
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.