目录产品 » IL-17A/CTLA-8[Biotin], His & Avi, Mouse
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IL-17A/CTLA-8[Biotin], His & Avi, Mouse

Interleukin‑17A (IL‑17A), also known as CTLA‑8, is a 15‑20 kDa glycosylated cytokine that plays an important role in anti‑microbial and chronic inflammation. The six IL‑17 cytokines (IL‑17A‑F) are encoded by separate genes but adopt a conserved cystine knot fold.IL-17A is a ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines.
￥5800
Z04666-100

产品简介
Species Mouse
Protein Construction
IL-17A/CTLA-8 (Ala26-Ala158)
Accession # Q62386-1		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Mouse IL­17R alpha at 2μg/ml (100μl/well) on the plate can bind IL-17A/CTLA-8[Biotin], His & Avi, Mouse. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 18 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 19-29 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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图例
IL-17A/CTLA-8[Biotin], His & Avi, Mouse

Immobilized Mouse IL-17R alpha, hFc Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for IL-17A/CTLA-8[Biotin], His & Avi, Mouse, His Tag with the EC50 of 28.3 ng/ml determined by ELISA. »

IL-17A/CTLA-8[Biotin], His & Avi, Mouse

IL-17A/CTLA-8[Biotin], His & Avi, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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技术背景
Target Background Interleukin‑17A (IL‑17A), also known as CTLA‑8, is a 15‑20 kDa glycosylated cytokine that plays an important role in anti‑microbial and chronic inflammation. The six IL‑17 cytokines (IL‑17A‑F) are encoded by separate genes but adopt a conserved cystine knot fold.IL-17A is a ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines.
Synonyms CTLA-8; IL17; IL17A; IL-17CTLA-8; interleukin 17A
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.